{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:57:42Z","timestamp":1765486662939},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0179_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Placental examination in a case of stillbirth can provide insight into causative\/associated factors with fetal demise. The aim of this study was to compare placental and umbilical cord pathologies in singleton stillbirth and livebirth placentas, and to find prevalence of various associated maternal and fetal clinical factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0179_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This case-control study was conducted at a tertiary-care center in India over a period of 20\u00a0months. About 250 women who delivered stillborn fetus\u00a0\u226528\u00a0weeks\u2019 gestation and 250 maternal-age-matched controls were recruited. Sociodemographic and clinical details were noted and placental gross and microscopic examination was done. Placental findings were compared between stillbirth and livebirth (overall), preterm stillbirth and preterm livebirth as well as term stillbirth and term livebirth in six categories\u00a0\u2013 placenta gross, cord gross, membranes gross, maternal vascular malperfusion, fetal vascular malperfusion and inflammatory response. Prevalence of 11 maternal and fetal factors were studied in all categories of placental findings in both livebirth and stillbirth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0179_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Placental findings in all six categories were significantly associated with stillbirths (p&lt;0.05). The placental findings associated with stillbirth with highest odds included placental hypoplasia (OR 9.77, 95% CI\u00a05.46\u201317.46), necrotizing chorioamnionitis (OR 9.30, 95% CI 1.17\u201373.96) and avascular villi (OR 8.45, 95% CI\u00a03.53\u201320.25). More than half of the women with stillbirths had medical disorders (n=130, 52.0%) and the most prevalent was hypertensive disorder (n=45, 18.0%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0179_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Changes in placenta are associated with development of stillbirth. Therefore, antenatal investigations to identify placental dysfunction should be investigated to determine whether these reduce stillbirth. Also, placental examination in a case of stillbirth can detect\/diagnose many maternal\/fetal conditions and thereby can help in preventing future stillbirths.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0179","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T23:10:03Z","timestamp":1632957003000},"page":"753-762","source":"Crossref","is-referenced-by-count":7,"title":["Placental findings in singleton stillbirths: a case-control study from a tertiary-care center in India"],"prefix":"10.1515","volume":"50","author":[{"given":"Purnima","family":"Tiwari","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynaecology , All India Institute of Medical Sciences Nagpur , Nagpur , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhavi M.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology , Maulana Azad Medical College and associated Lok Nayak Hospital , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyama Lata","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pathology , Maulana Azad Medical College , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"2023033123434462773_j_jpm-2021-0179_ref_001","doi-asserted-by":"crossref","unstructured":"Ptacek, I, Sebire, NJ, Man, JA, Brownbill, P, Heazell, AE. Systematic review of placental pathology reported in association with stillbirth. Placenta 2014;35:552\u201362. https:\/\/doi.org\/10.1016\/j.placenta.2014.05.011.","DOI":"10.1016\/j.placenta.2014.05.011"},{"key":"2023033123434462773_j_jpm-2021-0179_ref_002","doi-asserted-by":"crossref","unstructured":"Amir, H, Weintraub, A, Aricha-Tamir, B, Apel-Sarid, L, Holcberg, G, Sheiner, E. A piece in the puzzle of intrauterine fetal death: pathological findings in placentas from term and preterm intrauterine fetal death pregnancies. J Matern Fetal Neonatal Med 2009;22:759\u201364. https:\/\/doi.org\/10.3109\/14767050902929396.","DOI":"10.3109\/14767050902929396"},{"key":"2023033123434462773_j_jpm-2021-0179_ref_003","doi-asserted-by":"crossref","unstructured":"Helgad\u00f3ttir, LB, Turowski, G, Skjeldestad, FE, Jacobsen, AF, Sandset, PM, Roald, B, et al.. Classification of stillbirths and risk factors by cause of death\u00a0\u2013 a case-control study. 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