{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:54:42Z","timestamp":1759694082065,"version":"3.40.5"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"2","funder":[{"name":"Spanish Ministry of Health","award":["FIS Grant PI13\/02405"],"award-info":[{"award-number":["FIS Grant PI13\/02405"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0226_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Smoking during pregnancy is a leading and modifiable risk factor for fetal growth restriction (FGR) and low birthweight (&lt;10th centile). We studied the effects of smoking in the development of early and late FGR or low birthweight, as well as in uteroplacental and fetoplacental hemodynamics of growth-restricted fetuses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0226_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective cohort study of 5,537 consecutive singleton pregnancies delivered at\u00a0\u226434\u00a0+\u00a00 (\u201cearly delivery\u201d group, n=95) and &gt;34\u00a0+\u00a00 (\u201clate delivery\u201d group, n=5,442) weeks of gestation. Each group was divided into smokers and non-smokers. Prenatal diagnosis of FGR was based on\u00a0customized fetal growth standards and fetal Doppler, and\u00a0postnatal birthweight was assessed using the Olsen newborn chart.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0226_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 15\/95 (15.8%) and 602\/5,442 (11.1%) smokers in the early and late delivery groups, respectively. In early deliveries, FGR was diagnosed in 3\/15 (20%) of smokers and in 20\/80 (25%) of non-smokers (p=0.68). We also found no differences in birthweights and hemodynamics. In late deliveres, FGR was detected in 30\/602 (5%)\u00a0smokers and 64\/4,840 (1.3%) non-smokers (p&lt;0.001). Birthweights &lt;3rd centile and &lt;10th centile were more common in smokers vs. non-smokers: 38\/602 (6.3%) vs. 87\/4,840 (1.8%) and 89\/602 (14.8%) vs. 288\/4,840 (6%), respectively (all p&lt;0.01). Fetal Doppler of late FGR showed slightly higher umbilical artery resistances in smokers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0226_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Smoking in pregnancy is associated with FGR, low birthweight and higher umbilical artery Doppler resistances after 34\u00a0weeks of gestation, but we could not confirm this association in earlier deliveries.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0226","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T14:38:31Z","timestamp":1640011111000},"page":"200-206","source":"Crossref","is-referenced-by-count":9,"title":["Smoking influence on early and late fetal growth"],"prefix":"10.1515","volume":"50","author":[{"given":"Beatriz","family":"Fernandez-Rodriguez","sequence":"first","affiliation":[{"name":"Department of Pediatrics , University Hospital Del Tajo , Aranjuez , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Roche","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Neonatology , University Hospital 12 de Octubre, 12 de Octubre Research Institute (imas12), Complutense University of Madrid , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca Sofia","family":"Jimenez Moreno","sequence":"additional","affiliation":[{"name":"Department of Neonatology , University Hospital 12 de Octubre, 12 de Octubre Research Institute (imas12), Complutense University of Madrid , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"de Alba","sequence":"additional","affiliation":[{"name":"Department of Neonatology , University Hospital 12 de Octubre, 12 de Octubre Research Institute (imas12), Complutense University of Madrid , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Galindo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit-SAMID, Department of Obstetrics and Gynaecology , University Hospital 12 de Octubre, 12 de Octubre Research Institute (imas12), Complutense University of Madrid , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Villalain","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit-SAMID, Department of Obstetrics and Gynaecology , University Hospital 12 de Octubre, 12 de Octubre Research Institute (imas12), Complutense University of Madrid , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Pall\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Neonatology , University Hospital 12 de Octubre, 12 de Octubre Research Institute (imas12), Complutense University of Madrid , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6807-4944","authenticated-orcid":false,"given":"Ignacio","family":"Herraiz","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit-SAMID, Department of Obstetrics and Gynaecology , University Hospital 12 de Octubre, 12 de Octubre Research Institute (imas12), Complutense University of Madrid , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"2023033123352226885_j_jpm-2021-0226_ref_001","doi-asserted-by":"crossref","unstructured":"Blatt, K, Moore, E, Chen, A, Van Hook, J, De Franco, EA. 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