{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T11:06:30Z","timestamp":1743937590387},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0317_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>i) To compare the placental human papilloma virus (HPV) deoxynucleic acid (DNA) status of preterm deliveries with full term deliveries and to identify high risk\u00a0(HR) genotypes (HPV 16 and 18); and ii) To compare the perinatal outcomes of HPV positive with HPV negative pregnant women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0317_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A case control study was carried out on 100 antenatal women with singleton live pregnancies admitted in labor ward of a tertiary care teaching hospital from April 2017 to March 2018. The two study groups were i) spontaneous preterm deliveries between 24 and 36\u00a0+\u00a06\u00a0weeks (n=50) and ii) full term deliveries\u00a0\u226537\u00a0weeks (n=50). The placental tissue was analysed for HPV DNA and HR HPV genotypes were detected by type specific primers. A comparative analysis of perinatal outcomes between HPV positive and negative women was done.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0317_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>An overall placental tissue HPV prevalence of 12% (12\/100) was observed in study cohort which was not significantly different between preterm and full term deliveries (16 vs. 8%, p=0.218). HPV 16 was significantly associated with preterm births (p=0.04). Both HPV affected and non-affected women were comparable in terms of mode of delivery and neonatal outcomes. However, a statistically significant association of preterm neonatal intensive care admissions with HR HPV 16 genotype was observed (p=0.04).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0317_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Spontaneous preterm births can be attributed to placental HPV infection, specifically HR HPV 16\u00a0genotype. This association identifies a potentially preventable cause of prematurity and its associated complications, in wake of availability of an effective vaccine.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0317","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T11:50:04Z","timestamp":1641988204000},"page":"427-432","source":"Crossref","is-referenced-by-count":5,"title":["To evaluate the role of placental human papilloma virus (HPV) infection as a risk factor for spontaneous preterm birth: a prospective case control study"],"prefix":"10.1515","volume":"50","author":[{"given":"Reetu","family":"Hooda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology , Pt. B.D. Sharma PGIMS , Rohtak , Haryana , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeru","family":"Baghla","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , Employees\u2019 State Insurance Corporation Hospital , Noida , Uttar Pradesh , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , All India Institute of Medical Sciences , Bilaspur , Himachal Pradesh , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samander","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology , Maharshi Dayanand University , Rohtak , Haryana , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"2023040100043934734_j_jpm-2021-0317_ref_001","doi-asserted-by":"crossref","unstructured":"Goldenberg, RL, Culhane, JF, Iams, JD, Romero, R. 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