{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:08:37Z","timestamp":1759514917432,"version":"3.40.5"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"3","funder":[{"name":"Sociedad Profesional de Medicina Fetal \u2018Fetalmed\u2019 Ltda., Chile","award":["Unrestricted Research Grant"],"award-info":[{"award-number":["Unrestricted Research Grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0427_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To analyze umbilical artery (UA) Doppler velocimetry and its possible role in placenta-mediated fetal growth restriction (FGR) in second- and third-trimester fetuses with trisomy 18 and 13.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0427_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>UA pulsatility index (PI) and half-peak systolic velocity deceleration time (hPSV-DT) were measured in fetuses with trisomy 18 and 13. Correlation with gestational age, birthweight, and perinatal outcome was analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0427_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 80 measurements were taken from 33 fetuses with trisomy 18 and 19 with trisomy 13. Overall, there was a high prevalence of abnormal UA Doppler velocimetry. In fetuses with trisomy 18, 54% (27\/50) of the UA PI values and 58% (29\/50) of the UA hPSV-DT values were abnormal. In fetuses with trisomy 13, 80% (24\/30) of the UA PI values and 87% (26\/30) of the UA hPSV-DT values were abnormal. The prevalence of abnormal UA Doppler velocimetry increased with gestational age in both types of aneuploidy. However, this trend was only significant for trisomy 13 (p&lt;0.05). All fetuses with trisomy 18 and 86% of fetuses with trisomy 13 were classified at birth as FGR. There were no perinatal survivors in this series.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0427_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A high prevalence of abnormal UA Doppler velocimetry was found in second- and third-trimester fetuses with trisomy 18 and 13, which further increased with gestational age. These results may well correlate with alterations described previously in the placenta, suggesting placental insufficiency has an important role in the development of FGR in these autosomal aneuploid fetuses.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0427","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T08:01:49Z","timestamp":1639036909000},"page":"319-326","source":"Crossref","is-referenced-by-count":3,"title":["Umbilical artery pulsatility index and half-peak systolic velocity in second- and third-trimester fetuses with trisomy 18 and 13"],"prefix":"10.1515","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-9771","authenticated-orcid":false,"given":"Juan Carlos","family":"Bustos","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ultrasound Unit, San Juan de Dios Hospital, University of Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Vega","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ultrasound Unit, San Juan de Dios Hospital, University of Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-574X","authenticated-orcid":false,"given":"Waldo","family":"Sepulveda","sequence":"additional","affiliation":[{"name":"FETALMED\u2013Maternal-Fetal Diagnostic Center , Fetal Imaging Unit , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Figueras, F, Gratacos, E. Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol. Fetal Diagn Ther 2014;36:86\u201398. https:\/\/doi.org\/10.1159\/000357592.","key":"2023040100552195106_j_jpm-2021-0427_ref_001","DOI":"10.1159\/000357592"},{"doi-asserted-by":"crossref","unstructured":"Lees, C, Marlow, N, Arabin, B, Bilardo, CM, Brezinka, C, Derks, JB, et al.. Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE). Ultrasound Obstet Gynecol 2013;42:400\u20138. https:\/\/doi.org\/10.1002\/uog.13190.","key":"2023040100552195106_j_jpm-2021-0427_ref_002","DOI":"10.1002\/uog.13190"},{"doi-asserted-by":"crossref","unstructured":"Alfirevic, Z, Stampalija, T, Dowswell, T. Fetal and umbilical Doppler ultrasound in high\u2010risk pregnancies. Cochrane Database Syst Rev 2017;6:CD007529. https:\/\/doi.org\/10.1002\/14651858.CD007529.pub4.","key":"2023040100552195106_j_jpm-2021-0427_ref_003","DOI":"10.1002\/14651858.CD007529.pub4"},{"doi-asserted-by":"crossref","unstructured":"Bustos, JC, Paublo, M, Ramirez, P, Sepulveda, W. Umbilical artery half peak systolic velocity deceleration time throughout pregnancy and its role in fetuses with bradycardia. Ultrasound Obstet Gynecol 2007;30:952\u20137. https:\/\/doi.org\/10.1002\/uog.5185.","key":"2023040100552195106_j_jpm-2021-0427_ref_004","DOI":"10.1002\/uog.5185"},{"doi-asserted-by":"crossref","unstructured":"Bustos, JC, Gonzalez, V, Sepulveda, W. Umbilical artery half-peak systolic velocity deceleration time in fetal growth restriction. Fetal Diagn Ther 2016;40:128\u201334. https:\/\/doi.org\/10.1159\/000442049.","key":"2023040100552195106_j_jpm-2021-0427_ref_005","DOI":"10.1159\/000442049"},{"doi-asserted-by":"crossref","unstructured":"Bustos, JC, Herrera, A, Sepulveda, W. Umbilical artery pulsatility index and half-peak systolic velocity deceleration time in fetuses with trisomy 21. J Matern Fetal Neonatal Med 2020;33:3469\u201375. https:\/\/doi.org\/10.1080\/14767058.2019.1575357.","key":"2023040100552195106_j_jpm-2021-0427_ref_006","DOI":"10.1080\/14767058.2019.1575357"},{"doi-asserted-by":"crossref","unstructured":"Duque, JAP, Ferreira, CF, Zachia, SA, Sanseverino, MTV, Gus, R, Magalhaes, JAA. The natural history of pregnancies with prenatal diagnosis of trisomy 18 or trisomy 13: retrospective cases of a 23-year experience in a Brazilian public hospital. Genet Mol Biol 2019;42(1 Suppl):286\u201396. https:\/\/doi.org\/10.1590\/1678-4685-GMB-2018-0099.","key":"2023040100552195106_j_jpm-2021-0427_ref_007","DOI":"10.1590\/1678-4685-gmb-2018-0099"},{"doi-asserted-by":"crossref","unstructured":"Dall\u2019Asta, A, Brunelli, V, Prefumo, F, Frusca, T, Lees, CC. Early onset fetal growth restriction. Matern Health Neonatol Perinatol 2017;3:2. https:\/\/doi.org\/10.1186\/s40748-016-0041-x.","key":"2023040100552195106_j_jpm-2021-0427_ref_008","DOI":"10.1186\/s40748-016-0041-x"},{"doi-asserted-by":"crossref","unstructured":"Houlihan, O, O\u2019Donoghue, K. The natural history of pregnancies with a diagnosis of trisomy 18 or trisomy 13; a retrospective case series. BMC Pregnancy Childbirth 2013;13:209. https:\/\/doi.org\/10.1186\/1471-2393-13-209.","key":"2023040100552195106_j_jpm-2021-0427_ref_009","DOI":"10.1186\/1471-2393-13-209"},{"doi-asserted-by":"crossref","unstructured":"Lakovschek, IC, Streubel, B, Ulm, B. Natural outcome of trisomy 13, trisomy 18, and triploidy after prenatal diagnosis. Am J Med Genet 2011;155A:2626\u201333. https:\/\/doi.org\/10.1002\/ajmg.a.34284.","key":"2023040100552195106_j_jpm-2021-0427_ref_010","DOI":"10.1002\/ajmg.a.34284"},{"doi-asserted-by":"crossref","unstructured":"Meler, E, Sisterna, S, Borrell, A. Genetic syndromes associated with isolated fetal growth restriction. Prenat Diagn 2020;40:432\u201346. https:\/\/doi.org\/10.1002\/pd.5635.","key":"2023040100552195106_j_jpm-2021-0427_ref_011","DOI":"10.1002\/pd.5635"},{"doi-asserted-by":"crossref","unstructured":"Bhide, A, Acharya, G, Bilardo, CM, Brezinka, C, Cafici, D, Hernandez-Andrade, E, et al.. ISUOG practice guidelines: use of Doppler ultrasonography in obstetrics. Ultrasound Obstet Gynecol 2013;41:233\u20139. https:\/\/doi.org\/10.1002\/uog.12371.","key":"2023040100552195106_j_jpm-2021-0427_ref_012","DOI":"10.1002\/uog.12371"},{"doi-asserted-by":"crossref","unstructured":"Acharya, G, Wilsgaard, T, Berntsen, GK, Maltau, JM, Kiserud, T. Reference ranges for serial measurements of umbilical artery Doppler indices in the second half of pregnancy. Am J Obstet Gynecol 2005;192:937\u201344. https:\/\/doi.org\/10.1016\/j.ajog.2004.09.019.","key":"2023040100552195106_j_jpm-2021-0427_ref_013","DOI":"10.1016\/j.ajog.2004.09.019"},{"doi-asserted-by":"crossref","unstructured":"Bustos, JC, Gonzalez, V. Normal curves for fetal umbilical artery pulsatility index and half-peak systolic velocity deceleration time in Chilean population [in Spanish]. Rev Chil Obstet Ginecol 2014;79:255\u201361. https:\/\/doi.org\/10.4067\/s0717-75262014000400002.","key":"2023040100552195106_j_jpm-2021-0427_ref_014","DOI":"10.4067\/S0717-75262014000400002"},{"doi-asserted-by":"crossref","unstructured":"Milad, M, Novoa, JM, Fabres, J, Samame, M, Aspillaga, C. Recommendation on intrauterine growth curves [in Spanish]. Rev Chil Pediatr 2010;81:264\u201374. https:\/\/doi.org\/10.4067\/s0370-41062010000300011.","key":"2023040100552195106_j_jpm-2021-0427_ref_015","DOI":"10.4067\/S0370-41062010000300011"},{"doi-asserted-by":"crossref","unstructured":"Irving, C, Richmond, S, Wren, C, Longster, C, Embleton, ND. Changes in fetal prevalence and outcome for trisomies 13 and 18: a population-based study over 23 years. J Matern Fetal Neonatal Med 2011;24:137\u201341. https:\/\/doi.org\/10.3109\/14767051003758879.","key":"2023040100552195106_j_jpm-2021-0427_ref_016","DOI":"10.3109\/14767051003758879"},{"doi-asserted-by":"crossref","unstructured":"Jauniaux, E, Hustin, J. Chromosomally abnormal early ongoing pregnancies: correlation of ultrasound and placental histological findings. Hum Pathol 1998;29:1195\u20139. https:\/\/doi.org\/10.1016\/s0046-8177(98)90245-3.","key":"2023040100552195106_j_jpm-2021-0427_ref_017","DOI":"10.1016\/S0046-8177(98)90245-3"},{"doi-asserted-by":"crossref","unstructured":"Rochelson, B, Kaplan, C, Guzman, E, Arato, M, Hansen, K, Trunca, C. A quantitative analysis of placental vasculature in the third-trimester fetus with autosomal trisomy. Obstet Gynecol 1990;75:59\u201363. https:\/\/doi.org\/10.1016\/0020-7292(90)90676-c.","key":"2023040100552195106_j_jpm-2021-0427_ref_018","DOI":"10.1016\/0020-7292(90)90676-C"},{"doi-asserted-by":"crossref","unstructured":"Roberts, L, Sebire, NJ, Fowler, D, Nicolaides, KH. Histomorphological features of chorionic villi at 10\u201314\u00a0weeks of gestation in trisomic and chromosomally normal pregnancies. Placenta 2000;21:678\u201383. https:\/\/doi.org\/10.1053\/plac.2000.0553.","key":"2023040100552195106_j_jpm-2021-0427_ref_019","DOI":"10.1053\/plac.2000.0553"},{"doi-asserted-by":"crossref","unstructured":"Kuhlmann, RS, Werner, AL, Abramowicz, J, Warsof, SL, Arrington, J, Levy, DL. Placental histology in fetuses between 18 and 23\u00a0weeks\u2019 gestation with abnormal karyotype. Am J Obstet Gynecol 1990;163:1264\u201370. https:\/\/doi.org\/10.1016\/0002-9378(90)90704-b.","key":"2023040100552195106_j_jpm-2021-0427_ref_020","DOI":"10.1016\/0002-9378(90)90704-B"},{"doi-asserted-by":"crossref","unstructured":"Corry, E, Mone, F, Segurado, R, Downey, P, McParland, P, McAuliffe, FM, et al.. Placental disease and abnormal umbilical artery Doppler waveforms in trisomy 21 pregnancy: a case-control study. Placenta 2016;47:24\u20138. https:\/\/doi.org\/10.1016\/j.placenta.2016.09.001.","key":"2023040100552195106_j_jpm-2021-0427_ref_021","DOI":"10.1016\/j.placenta.2016.09.001"},{"doi-asserted-by":"crossref","unstructured":"Wegrzyn, P, Faro, C, Falcon, O, Peralta, CFA, Nicolaides, KH. Placental volume measured by three-dimensional ultrasound at 11 to 13+6\u00a0weeks of gestation: relation to chromosomal defects. Ultrasound Obstet Gynecol 2005;26:28\u201332. https:\/\/doi.org\/10.1002\/uog.1923.","key":"2023040100552195106_j_jpm-2021-0427_ref_022","DOI":"10.1002\/uog.1923"},{"doi-asserted-by":"crossref","unstructured":"Rizzo, G, Capponi, A, Cavicchioni, O, Vendola, M, Arduini, D. Placental vascularization measured by three-dimensional power Doppler ultrasound at 11 to 13+6\u00a0weeks\u2019 gestation in normal and aneuploid fetuses. Ultrasound Obstet Gynecol 2007;30:259\u201362. https:\/\/doi.org\/10.1002\/uog.4092.","key":"2023040100552195106_j_jpm-2021-0427_ref_023","DOI":"10.1002\/uog.4092"},{"doi-asserted-by":"crossref","unstructured":"Staboulidou, I, Galindo, A, Maiz, N, Karagiannis, G, Nicolaides, KH. First-trimester uterine artery Doppler and serum pregnancy-associated plasma protein-A in preeclampsia and chromosomal defects. Fetal Diagn Ther 2009;25:336\u20139. https:\/\/doi.org\/10.1159\/000235880.","key":"2023040100552195106_j_jpm-2021-0427_ref_024","DOI":"10.1159\/000235880"},{"doi-asserted-by":"crossref","unstructured":"Bindra, R, Curcio, P, Cicero, S, Martin, A, Nicolaides, KH. Uterine artery Doppler at 11\u201314\u00a0weeks of gestation in chromosomally abnormal fetuses. Ultrasound Obstet Gynecol 2001;18:587\u20139. https:\/\/doi.org\/10.1046\/j.0960-7692.2001.00585.x.","key":"2023040100552195106_j_jpm-2021-0427_ref_025","DOI":"10.1046\/j.0960-7692.2001.00585.x"},{"doi-asserted-by":"crossref","unstructured":"Jauniaux, E, Gavrill, P, Khun, P, Kurdi, W, Hyett, J, Nicolaides, KH. Fetal heart rate and umbilico-placental Doppler flow velocity waveforms in early pregnancies with a chromosomal abnormality and\/or an increased nuchal translucency thickness. Hum Reprod 1996;11:435\u20139. https:\/\/doi.org\/10.1093\/humrep\/11.2.435.","key":"2023040100552195106_j_jpm-2021-0427_ref_026","DOI":"10.1093\/HUMREP\/11.2.435"},{"doi-asserted-by":"crossref","unstructured":"Zoppi, MA, Ibba, RM, Putzolu, M, Floris, M, Monni, G. First trimester umbilical artery pulsatility index in fetuses presenting enlarged nuchal translucency. Prenat Diagn 2000;20:701\u20134. https:\/\/doi.org\/10.1002\/1097-0223(200009)20:9<701::aid-pd902>3.0.co;2-m.","key":"2023040100552195106_j_jpm-2021-0427_ref_027","DOI":"10.1002\/1097-0223(200009)20:9<701::AID-PD902>3.0.CO;2-M"},{"doi-asserted-by":"crossref","unstructured":"Martinez, JM, Antolin, E, Borrell, A, Puerto, B, Casals, E, Ojuel, J, et al.. Umbilical Doppler velocimetry in fetuses with trisomy 18 at 10\u201318\u00a0weeks\u2019 gestation. Prenat Diagn 1997;17:319\u201322. https:\/\/doi.org\/10.1002\/(sici)1097-0223(199704)17:4<319::aid-pd26>3.0.co;2-p.","key":"2023040100552195106_j_jpm-2021-0427_ref_028","DOI":"10.1002\/(SICI)1097-0223(199704)17:4<319::AID-PD26>3.0.CO;2-P"},{"doi-asserted-by":"crossref","unstructured":"Martinez Crespo, JM, Comas, C, Borrell, A, Puerto, B, Antolin, E, Ojuel, J, et al.. Reversed end-diastolic umbilical artery velocity in two cases of trisomy 18 at 10\u00a0weeks\u2019 gestation. Ultrasound Obstet Gynecol 1996;7:447\u20139. https:\/\/doi.org\/10.1046\/j.1469-0705.1996.07060447.x.","key":"2023040100552195106_j_jpm-2021-0427_ref_029","DOI":"10.1046\/j.1469-0705.1996.07060447.x"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2021-0427\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2021-0427\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T17:15:22Z","timestamp":1680369322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2021-0427\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,12,16]]},"published-print":{"date-parts":[[2022,3,28]]}},"alternative-id":["10.1515\/jpm-2021-0427"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2021-0427","relation":{},"ISSN":["0300-5577","1619-3997"],"issn-type":[{"type":"print","value":"0300-5577"},{"type":"electronic","value":"1619-3997"}],"subject":[],"published":{"date-parts":[[2021,12,8]]}}}