{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T16:50:57Z","timestamp":1758991857571,"version":"3.40.5"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0495_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine whether preimplantation genetic testing for aneuploidy (PGT-A) is associated with a reduced risk of abnormal conventional prenatal screening results in singleton pregnancies conceived using <jats:italic>in vitro<\/jats:italic> fertilization (IVF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0495_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective cohort study of singleton IVF pregnancies conceived from a single tertiary care center between January 2014 and September 2019. Exclusion criteria included mosaic embryo transfers, vanishing twin pregnancies, and cycles with missing outcome data. Two cases of prenatally diagnosed aneuploidy that resulted in early voluntary terminations were also excluded. The primary outcome of abnormal first or second-trimester combined screening results was compared between two groups: pregnancy conceived after transfer of a euploid embryo by PGT-A vs. transfer of an untested embryo. Multivariable backwards-stepwise logistic regression with Firth method was used to adjust for potential confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0495_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 419 pregnancies included, 208 (49.6%) were conceived after transfer of a euploid embryo by PGT-A, and 211 (50.4%) were conceived after transfer of an untested embryo. PGT-A was not associated with a lower likelihood of abnormal first-trimester (adjusted OR 1.64, 95% CI 0.82\u20133.39) or second-trimester screening results (adjusted OR 0.96, 95% CI 0.56\u20131.64). The incidences of cell-free DNA testing, fetal sonographic abnormalities, genetic counseling, and invasive prenatal diagnostic testing were similar between the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0495_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data suggest that PGT-A is not associated with a change in the likelihood of abnormal prenatal screening results or utilization of invasive prenatal diagnostic testing. Counseling this patient population regarding the importance of prenatal screening and prenatal diagnostic testing, where appropriate, remains essential.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0495","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T10:35:36Z","timestamp":1638009336000},"page":"300-304","source":"Crossref","is-referenced-by-count":2,"title":["The impact of preimplantation genetic testing for aneuploidy on prenatal screening"],"prefix":"10.1515","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-9578","authenticated-orcid":false,"given":"Moti","family":"Gulersen","sequence":"first","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , North Shore University Hospital\u00a0\u2013 Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , Manhasset , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Peyser","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology , North Shore University Hospital\u00a0\u2013 Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , Manhasset , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , North Shore University Hospital\u00a0\u2013 Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , Manhasset , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , Hempstead , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randi","family":"Goldman","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology , North Shore University Hospital\u00a0\u2013 Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , Manhasset , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Mullin","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology , North Shore University Hospital\u00a0\u2013 Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , Manhasset , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Li","sequence":"additional","affiliation":[{"name":"Eurofins NTD , Melville , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Krantz","sequence":"additional","affiliation":[{"name":"Eurofins NTD , Melville , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eran","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Lenox Hill Hospital\u00a0\u2013 Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , New York , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burton","family":"Rochelson","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , North Shore University Hospital\u00a0\u2013 Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , Manhasset , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"2023040100552193195_j_jpm-2021-0495_ref_001","unstructured":"American College of Obstetricians and Gynecologists. 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