{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:36:12Z","timestamp":1774611372958,"version":"3.50.1"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0498_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the association between low regional cerebral oxygen saturation (rScO2) and neurodevelopment in preterm infants classified as no brain injury (NBI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0498_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively reviewed data of rScO2 monitoring during the first 3\u00a0days of life of infants with a gestational age (GA)&lt;28\u00a0weeks or birth weight (BW)&lt;1,000\u00a0g, with and without brain injury (BI). BI was defined as intraventricular haemorrhage, cystic periventricular leukomalacia or cerebellar haemorrhage. Univariate and multivariate analyses were used to study the association of rScO2&lt;55% for more than 10\u00a0h in the first 3\u00a0days of life (NIRS&lt;55%<jats:sup>&gt;10H<\/jats:sup>) and the 24\u00a0months neurodevelopment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0498_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 185 patients who met the inclusion criteria, 31% were classified as BI infants and 69% NBI. BI compared to NBI infants had a significantly lower GA and a higher incidence of complications of prematurity. Mean rScO2 in the first 72\u00a0h of life was significantly lower in BI than NBI. NIRS&lt;55%<jats:sup>&gt;10H<\/jats:sup> in NBI patients was negatively associated with neurodevelopmental scores both at the univariate and\u00a0multivariate analysis (p&lt;0.05). NBI infants with NIRS&lt;55%<jats:sup>&gt;10H<\/jats:sup> were found to have lower systemic oxygenation than their counterparts with rScO2&lt;55% for less than 10\u00a0h.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0498_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>NIRS&lt;55%<jats:sup>&gt;10H<\/jats:sup> in NBI small preterm infants was found to be an independent predictor of neurodevelopment at 24\u00a0months and it was associated with low systemic saturation values.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0498","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T17:06:13Z","timestamp":1647968773000},"page":"625-629","source":"Crossref","is-referenced-by-count":7,"title":["Is low cerebral near infrared spectroscopy oximetry associated with neurodevelopment of preterm infants without brain injury?"],"prefix":"10.1515","volume":"50","author":[{"given":"Stefano","family":"Tombolini","sequence":"first","affiliation":[{"name":"Department of Odontostomatologic and Specialized Clinical Sciences , Polytechnic University of Marche , Ancona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Division of Neonatology , Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I - G. M. Lancisi - G. Salesi , Ancona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-7806","authenticated-orcid":false,"given":"Alessio","family":"Correani","sequence":"additional","affiliation":[{"name":"Department of Odontostomatologic and Specialized Clinical Sciences , Polytechnic University of Marche , Ancona , Italy"},{"name":"Division of Neonatology , Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I - G. M. Lancisi - G. Salesi , Ancona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Marchionni","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Unica Regionale Marche AV3, U.O.C. Ingegneria Clinica , Ancona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Monachesi","sequence":"additional","affiliation":[{"name":"Department of Odontostomatologic and Specialized Clinical Sciences , Polytechnic University of Marche , Ancona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Division of Neonatology , Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I - G. M. Lancisi - G. Salesi , Ancona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Staffolani","sequence":"additional","affiliation":[{"name":"Division of Neonatology , Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I - G. M. Lancisi - G. Salesi , Ancona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"D\u2019Ascenzo","sequence":"additional","affiliation":[{"name":"Division of Neonatology , Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I - G. M. Lancisi - G. Salesi , Ancona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virgilio","family":"Carnielli","sequence":"additional","affiliation":[{"name":"Department of Odontostomatologic and Specialized Clinical Sciences , Polytechnic University of Marche , Ancona , Italy"},{"name":"Division of Neonatology , Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I - G. M. Lancisi - G. Salesi , Ancona , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"2023040100573186770_j_jpm-2021-0498_ref_001","doi-asserted-by":"crossref","unstructured":"Dix, LML, van Bel, F, Lemmers, PMA. 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