{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:08:55Z","timestamp":1786964935729,"version":"build-2736575974"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0542_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To compare the immunohistochemical expression of IL-6 in placental membranes of late preterm delivery in women with histologically proven chorioamnionitis with\u00a0and without preterm premature rupture of membranes (PPROM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0542_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Fetal membranes were collected from 60 women who had late preterm delivery with histologic chorioamnionitis with and without PPROM (30 in each group). Immunohistochemistry for IL-6 was performed on formalin fixed and paraffin-embedded sections. The two groups were matched for age, body mass index and parity. SPSS Version 17.0 was used for statistical analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0542_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There was no difference in immunohistochemical expression of IL-6 in placental membranes of women with histologic chorioamnionitis regardless of the membrane status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0542_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Chorioamnionitis has no impact on immunohistochemical expression of IL-6 in placental membranes of women with late preterm delivery despite the clinical presentation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0542","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T18:18:03Z","timestamp":1639160283000},"page":"386-390","source":"Crossref","is-referenced-by-count":2,"title":["Chorioamnionitis has no impact on immunohistochemical expression of IL-6 in placental membranes of the late preterm delivery regardless of the membrane status"],"prefix":"10.1515","volume":"50","author":[{"given":"Zdeslav","family":"Benzon","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics , University Hospital and School of Medicine, University of Split , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Kuzmi\u0107 Prusac","sequence":"additional","affiliation":[{"name":"Institute for Pathology, University Hospital and School of Medicine , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Zeki\u0107 Toma\u0161","sequence":"additional","affiliation":[{"name":"Institute for Pathology, University Hospital and School of Medicine , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Vuli\u0107","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , University Hospital and School of Medicine, University of Split , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luka","family":"Vuli\u0107","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , University Hospital Center \u201cSisters of Mercy\u201d , Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Benzon","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , University Hospital and School of Medicine, University of Split , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5230-1698","authenticated-orcid":false,"given":"Vedran","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Fetomaternal Medical Center, Helsinki University Hospital and University of Helsinki , Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"2023040100043919603_j_jpm-2021-0542_ref_001","doi-asserted-by":"crossref","unstructured":"Davidoff, MJ, Dias, T, Damus, K, Russell, R, Bettegowda, VR, Dolan, S, et al.. Changes in the gestational age distribution among U.S. singleton births: impact on rates of late preterm birth, 1992 to 2002. Semin Perinatol 2006;30:8\u201315. https:\/\/doi.org\/10.1053\/j.semperi.2006.01.009.","DOI":"10.1053\/j.semperi.2006.01.009"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_002","doi-asserted-by":"crossref","unstructured":"Shapiro-Mendoza, CK, Tomashek, KM, Kotelchuck, M, Barfield, W, Weiss, J, Evans, S. Risk factors for neonatal morbidity and mortality among \u201chealthy,\u201d late preterm newborns. Semin Perinatol 2006;30:54\u201360. https:\/\/doi.org\/10.1053\/j.semperi.2006.02.002.","DOI":"10.1053\/j.semperi.2006.02.002"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_003","doi-asserted-by":"crossref","unstructured":"B\u00e9nin, A, Blanc, M, Chollat, C, Jarreau, P-H, Goffinet, F, Tsatsaris, V, et al.. The cause of birth is associated with neonatal prognosis in late preterm singletons. J Gynecol Obstet Hum Reprod 2020;49:101920. https:\/\/doi.org\/10.1016\/j.jogoh.2020.101920.","DOI":"10.1016\/j.jogoh.2020.101920"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_004","doi-asserted-by":"crossref","unstructured":"Aziz, N, Cheng, YW, Caughey, AB. Neonatal outcomes in the setting of preterm premature rupture of membranes complicated by chorioamnionitis. J Matern Fetal Neonatal Med 2009;22:780\u20134. https:\/\/doi.org\/10.3109\/14767050902922581.","DOI":"10.3109\/14767050902922581"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_005","doi-asserted-by":"crossref","unstructured":"Taylor, BD, Holzman, CB, Fichorova, RN, Tian, Y, Jones, NM, Fu, W, et al.. Inflammation biomarkers in vaginal fluid and preterm delivery. Hum Reprod 2013;28:942\u201352. https:\/\/doi.org\/10.1093\/humrep\/det019.","DOI":"10.1093\/humrep\/det019"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_006","doi-asserted-by":"crossref","unstructured":"Boyle, AK, Rinaldi, SF, Norman, JE, Stock, SJ. Preterm birth: inflammation, fetal injury and treatment strategies. J Reprod Immunol 2017;119:62\u20136. https:\/\/doi.org\/10.1016\/j.jri.2016.11.008.","DOI":"10.1016\/j.jri.2016.11.008"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_007","doi-asserted-by":"crossref","unstructured":"Romero, R, Gomez-Lopez, N, Winters, AD, Jung, E, Shaman, M, Bieda, J, et al.. Evidence that intra-amniotic infections are often the result of an ascending invasion\u00a0\u2013 a molecular microbiological study. J\u00a0Perinat Med 2019;47:915\u201331. https:\/\/doi.org\/10.1515\/jpm-2019-0297.","DOI":"10.1515\/jpm-2019-0297"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_008","doi-asserted-by":"crossref","unstructured":"Noda-Nicolau, NM, Polettini, J, da Silva, MG, Peltier, MR, Menon, R. Polybacterial stimulation suggests discrete IL-6\/IL-6R signaling in human fetal membranes: potential implications on IL-6 bioactivity. J Reprod Immunol 2018;126:60\u20138. https:\/\/doi.org\/10.1016\/j.jri.2018.02.007.","DOI":"10.1016\/j.jri.2018.02.007"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_009","doi-asserted-by":"crossref","unstructured":"Menard, JP, Mazouni, C, Salem-Cherif, I, Fenollar, F, Raoult, D, Boubli, L, et al.. High vaginal concentrations of Atopobium vaginae and Gardnerella vaginalis in women undergoing preterm labor. Obstet Gynecol 2010;115:134\u201340. https:\/\/doi.org\/10.1097\/AOG.0b013e3181c391d7.","DOI":"10.1097\/AOG.0b013e3181c391d7"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_010","doi-asserted-by":"crossref","unstructured":"Menon, R, Richardson, LS. Preterm prelabor rupture of the membranes: a disease of the fetal membranes. Semin Perinatol 2017;41:409\u201319. https:\/\/doi.org\/10.1053\/j.semperi.2017.07.012.","DOI":"10.1053\/j.semperi.2017.07.012"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_011","doi-asserted-by":"crossref","unstructured":"Romero, R, Miranda, J, Chaiworapongsa, T, Korzeniewski, SJ, Chaemsaithong, P, Gotsch, F, et al.. Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Reprod Immunol 2014;72:458\u201374. https:\/\/doi.org\/10.1111\/aji.12296.","DOI":"10.1111\/aji.12296"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_012","doi-asserted-by":"crossref","unstructured":"Menon, R, Taylor, RN, Fortunato, SJ. Chorioamnionitis\u00a0\u2013 a complex pathophysiologic syndrome. Placenta 2010;31:113\u201320. https:\/\/doi.org\/10.1016\/j.placenta.2009.11.012.","DOI":"10.1016\/j.placenta.2009.11.012"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_013","doi-asserted-by":"crossref","unstructured":"Fortunato, SJ, Menon, R, Lombardi, SJ. Collagenolytic enzymes (gelatinases) and their inhibitors in human amniochorionic membrane. Am J Obstet Gynecol 1997;177:731\u201341. https:\/\/doi.org\/10.1016\/s0002-9378(97)70260-6.","DOI":"10.1016\/S0002-9378(97)70260-6"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_014","doi-asserted-by":"crossref","unstructured":"Athayde, N, Edwin, SS, Romero, R, Gomez, R, Maymon, E, Pacora, P, et al.. A role for matrix metalloproteinase-9 in spontaneous rupture of the fetal membranes. Am J Obstet Gynecol 1998;179:1248\u201353. https:\/\/doi.org\/10.1016\/s0002-9378(98)70141-3.","DOI":"10.1016\/S0002-9378(98)70141-3"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_015","doi-asserted-by":"crossref","unstructured":"Lee, SY, Buhimschi, IA, Dulay, AT, Ali, UA, Zhao, G, Abdel-Razeq, SS, et al.. IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes. J Immunol 2011;186:3226\u201336. https:\/\/doi.org\/10.4049\/jimmunol.1003587.","DOI":"10.4049\/jimmunol.1003587"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_016","doi-asserted-by":"crossref","unstructured":"Saji, F, Samejima, Y, Kamiura, S, Sawai, K, Shimoya, K, Kimura, T. Cytokine production in chorioamnionitis. J Reprod Immunol 2000;47:185\u201396. https:\/\/doi.org\/10.1016\/s0165-0378(00)00064-4.","DOI":"10.1016\/S0165-0378(00)00064-4"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_017","doi-asserted-by":"crossref","unstructured":"Redline, RW. Inflammatory response in acute chorioamnionitis. Semin Fetal Neonatal Med 2012;17:20\u20135. https:\/\/doi.org\/10.1016\/j.siny.2011.08.003.","DOI":"10.1016\/j.siny.2011.08.003"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_018","doi-asserted-by":"crossref","unstructured":"Benzon, Z, Benzon, S, Toma\u0161, SZ, Prusac, IK, Vuli\u0107, L, Vuli\u0107, M, et al.. Immunohistochemical demonstration of RECK protein and interleukin-6 in fetal membranes from singleton pregnancies with late preterm delivery. Biotech Histochem 2018;93:575\u201380. https:\/\/doi.org\/10.1080\/10520295.2018.1511061.","DOI":"10.1080\/10520295.2018.1511061"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_019","doi-asserted-by":"crossref","unstructured":"Myntti, T, Rahkonen, L, Nupponen, I, P\u00e4t\u00e4ri-Sampo, A, Tikkanen, M, Sorsa, T, et al.. Amniotic fluid infection in preterm pregnancies with intact membranes. Dis Markers 2017;2017:1\u20139. https:\/\/doi.org\/10.1155\/2017\/8167276.","DOI":"10.1155\/2017\/8167276"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_020","doi-asserted-by":"crossref","unstructured":"Tanaka, T, Narazaki, M, Kishimoto, T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 2014;6:a016295. https:\/\/doi.org\/10.1101\/cshperspect.a016295.","DOI":"10.1101\/cshperspect.a016295"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_021","doi-asserted-by":"crossref","unstructured":"Menon, R, Peltier, MR, Eckardt, J, Fortunato, SJ. Diversity in cytokine response to bacteria associated with preterm birth by fetal membranes. Am J Obstet Gynecol 2009;201:306.e1\u20136. https:\/\/doi.org\/10.1016\/j.ajog.2009.06.027.","DOI":"10.1016\/j.ajog.2009.06.027"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_022","doi-asserted-by":"crossref","unstructured":"Mitazaki, S, Hashimoto, M, Matsuhashi, Y, Honma, S, Suto, M, Kato, N, et al.. Interleukin-6 modulates oxidative stress produced during the development of cisplatin nephrotoxicity. Life Sci 2013;92:694\u2013700. https:\/\/doi.org\/10.1016\/j.lfs.2013.01.026.","DOI":"10.1016\/j.lfs.2013.01.026"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_023","doi-asserted-by":"crossref","unstructured":"Schett, G. Physiological effects of modulating the interleukin-6 axis. Rheumatology 2018;57(2 Suppl):ii43\u201350. https:\/\/doi.org\/10.1093\/rheumatology\/kex513.","DOI":"10.1093\/rheumatology\/kex513"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_024","doi-asserted-by":"crossref","unstructured":"Matthews, V, Schuster, B, Sch\u00fctze, S, Bussmeyer, I, Ludwig, A, Hundhausen, C, et al.. Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem 2003;278:38829\u201339. https:\/\/doi.org\/10.1074\/jbc.M210584200.","DOI":"10.1074\/jbc.M210584200"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_025","doi-asserted-by":"crossref","unstructured":"Heinrich, PC, Castell, JV, Andus, T. Interleukin-6 and the acute phase response. Biochem J 1990;265:621\u201336. https:\/\/doi.org\/10.1042\/bj2650621.","DOI":"10.1042\/bj2650621"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_026","doi-asserted-by":"crossref","unstructured":"Lockwood, CJ, Murk, WK, Kayisli, UA, Buchwalder, LF, Huang, SJ, Arcuri, F, et al.. Regulation of interleukin-6 expression in human decidual cells and its potential role in chorioamnionitis. Am J Pathol 2010;177:1755\u201364. https:\/\/doi.org\/10.2353\/ajpath.2010.090781.","DOI":"10.2353\/ajpath.2010.090781"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_027","doi-asserted-by":"crossref","unstructured":"Turkay, E, Ozmen, A, Unek, G, Mendilcioglu, I. The effects of glucocorticoids on fetal and placental development. In: Qian, X, editor. Glucocorticoids\u00a0\u2013 new recognition of our familiar friend. InTech; 2012. Available from: http:\/\/www.intechopen.com\/books\/glucocorticoids-new-recognition-of-our-familiar-friend\/the-effects-of-glucocorticoids-on-fetal-and-placental-development [Cited 28 Jul 2021].","DOI":"10.5772\/50103"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_028","doi-asserted-by":"crossref","unstructured":"Hantoushzadeh, S, Anvari Aliabad, R, Norooznezhad, AH. Antibiotics, inflammation, and preterm labor: a missed conclusion. J Inflamm Res 2020;13:245\u201354. https:\/\/doi.org\/10.2147\/JIR.S248382.","DOI":"10.2147\/JIR.S248382"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_029","doi-asserted-by":"crossref","unstructured":"Sugimoto, J, Romani, AM, Valentin-Torres, AM, Luciano, AA, Ramirez Kitchen, CM, Funderburg, N, et al.. Magnesium decreases inflammatory cytokine production: a novel innate immunomodulatory mechanism. J Immunol 2012;188:6338\u201346. https:\/\/doi.org\/10.4049\/jimmunol.1101765.","DOI":"10.4049\/jimmunol.1101765"},{"key":"2023040100043919603_j_jpm-2021-0542_ref_030","doi-asserted-by":"crossref","unstructured":"Sayed Ahmed, WA, Ahmed, MR, Mohamed, ML, Hamdy, MA, Kamel, Z, Elnahas, KM. Maternal serum interleukin-6 in the management of patients with preterm premature rupture of membranes. J Matern Fetal Neonatal Med 2016;29:3162\u20136. https:\/\/doi.org\/10.3109\/14767058.2015.1118036.","DOI":"10.3109\/14767058.2015.1118036"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2021-0542\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2021-0542\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T13:52:27Z","timestamp":1680357147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2021-0542\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,13]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,3,11]]},"published-print":{"date-parts":[[2022,5,25]]}},"alternative-id":["10.1515\/jpm-2021-0542"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2021-0542","relation":{},"ISSN":["0300-5577","1619-3997"],"issn-type":[{"value":"0300-5577","type":"print"},{"value":"1619-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,13]]}}}