{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:50:03Z","timestamp":1747198203596,"version":"3.40.5"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0562_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In the mid-trimester ultrasound, nasal bone (NB) length can be used to correct the <jats:italic>a priori<\/jats:italic> risk for trisomy 21. Our study aims to evaluate if there is a correlation between an absent NB in the first trimester and a hypoplastic NB in the second trimester.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0562_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Our two year retrospective analysis of data derived from routine clinical practice. Single euploid fetuses were included. The NB was assessed in both trimesters according to international guidelines and transformed into categorical variables. Logistic regression was performed in order to accomplish our main objective.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0562_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From the 759 normal pregnancies included, 45 (5.93%) had abnormal NB in the first trimester and 23 (3%) in the second trimester. Eleven cases (47.8%) of the abnormal NB in the second trimester were abnormal in the\u00a011\u201314\u00a0weeks scan. After the diagnosis of an absent NB in\u00a0the first trimester the odds ratio (OR) for a hypoplastic NB in the second trimester is 18.926 (7.791\u201345.977; p-value &lt;0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0562_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data suggest a strong association between the NB in the first and in the second trimester in\u00a0normal euploid fetuses. This is important information to\u00a0consider when counseling patients on the basis of this ultrasound marker.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0562","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T19:49:20Z","timestamp":1643312960000},"page":"462-466","source":"Crossref","is-referenced-by-count":2,"title":["Nasal bone in fetal aneuploidy risk assessment: are they independent markers in the first and second trimesters?"],"prefix":"10.1515","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0586-3369","authenticated-orcid":false,"given":"Joana","family":"Bernardeco","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department , Centro Hospitalar de Set\u00fabal , Set\u00fabal , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jader","family":"Cruz","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit , Centro Hospitalar Universit\u00e1rio Lisboa Central , Lisbon , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Rijo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit , Centro Hospitalar Universit\u00e1rio Lisboa Central , Lisbon , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Cohen","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit , Centro Hospitalar Universit\u00e1rio Lisboa Central , Lisbon , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"2023040100043928161_j_jpm-2021-0562_ref_001","doi-asserted-by":"crossref","unstructured":"Nicolaides, KH. 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