{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:52:12Z","timestamp":1780923132730,"version":"3.54.1"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2022-0118_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We conducted a systematic review and meta-analysis to quantitatively summarize the present data on the association of prenatally identified lateral placenta in singleton pregnancies with small for gestational age (SGA) neonates, preeclampsia and other perinatal outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0118_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From inception to November 2021, we searched PubMed\/Medline, Scopus and The Cochrane Library for papers comparing the risk of SGA and preeclampsia, as well as other perinatal outcomes in singleton pregnancies with a prenatally identified lateral placenta to those with non-lateral placentas. The revised Newcastle-Ottawa Scale was used to evaluate the quality of eligible papers. The I<jats:sup>2<\/jats:sup>\u00a0test was employed to evaluate the heterogeneity of outcomes among the studies. To investigate the possibility of publication bias, funnel plots were constructed. Prospero RN: CRD42021251590.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0118_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The search yielded 5,420 articles, of which 16 were chosen, comprising of 15 cohort studies and one case control study with a total of 4,947 cases of lateral and 96,035 of non-lateral placenta (controls) reported. SGA neonates were more likely to be delivered in cases with a lateral placenta (OR: 1.74; 95% CI: 1.54\u20131.96; p&lt;0.00001; I<jats:sup>2<\/jats:sup>=47%). Likewise, placental laterality was linked to a higher risk of fetal growth restriction (OR: 2.18; 95% CI:\u00a01.54\u20133.06; p&lt;0.00001; I2=0%), hypertensive disorders of pregnancy (OR: 2.39; 95% CI: 1.65\u20133.51; p=0.0001; I<jats:sup>2<\/jats:sup>=80%), preeclampsia (OR: 2.92; 95% CI: 1.92\u20134.44; p&lt;0.0001; I<jats:sup>2<\/jats:sup>=82%) and preterm delivery (OR: 1.65; 95% CI:\u00a01.46\u20131.87; p&lt;0.00001; I<jats:sup>2<\/jats:sup>=0%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0118_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The prenatal diagnosis of a lateral placenta appears to be associated with a higher incidence of preeclampsia, fetal growth restriction, preterm delivery and SGA. This may prove useful in screening for these conditions at the second trimester anomaly scan.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2022-0118","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T19:12:48Z","timestamp":1664478768000},"page":"468-476","source":"Crossref","is-referenced-by-count":5,"title":["The impact of lateral placenta on preeclampsia and small for gestational age neonates: a systematic review and meta-analysis"],"prefix":"10.1515","volume":"51","author":[{"given":"Antonios","family":"Siargkas","sequence":"first","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki , Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-7871","authenticated-orcid":false,"given":"Ioannis","family":"Tsakiridis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki , Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Grammenos","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki , Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Apostolopoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki , Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Giouleka","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki , Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Mamopoulos","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki , Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Athanasiadis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki , Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-5839","authenticated-orcid":false,"given":"Themistoklis","family":"Dagklis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki , Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"2023050402001742697_j_jpm-2022-0118_ref_001","doi-asserted-by":"crossref","unstructured":"Seckin, KD, Cakmak, B, Karsli, MF, Yeral, MI, Gultekin, IB, Oz, M, et al.. 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