{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:38:10Z","timestamp":1785800290185,"version":"3.56.0"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2022-0121_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the influence of maternal level of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) one by one or in combination on incidence of gestational hypertension and preeclampsia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0121_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study included pregnant women (n=107) hospitalized in the period from July 1, 2020 to October 10, 2021\u00a0at the Department of Pathology of Pregnancy of the University Clinic of Obstetrics and Gynecology, University Clinical Center Sarajevo (UCCS) (Bosnia and Herzegovina), due to hypertensive disorder in pregnancy without symptoms of impaired thyroid function. In all patients fulfilling inclusion criteria TSH, FT3, and FT4 using electrochemiluminescence immunoassay (ECLIA, Roche Diagnostics, Basel, Switzerland) were checked. There were two groups of patients: one with gestational hypertension (G1) and the other with preeclampsia (G2). The programs SPSS for Windows 25.0, SPSS Inc, Chicago, IL, USA and Microsoft Excel 11, Microsoft Corporation, Redmond, WA, USA were used for statistical analysis using nonparametric Mann-Whitney U test because the distribution of the data was not normal. The result was considered statistically significant if p&lt;0.05.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0121_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Gestational age at delivery (G2 36.86\u00a0\u00b1\u00a03.79 vs. G1 38.94\u00a0\u00b1\u00a02.15; p=0.002) and birth weight (G2 2,841.36\u00a0\u00b1\u00a01,006.39 vs. G2 3,290.73\u00a0\u00b1\u00a0745.6; p=0,032) were significantly different between the investigated groups. The difference between the peak systolic (p=0.002), peak diastolic blood pressure (p=0.007), TSH (p=0.044), and FT3 (p=0.045) were statistically significant. Impaired thyroid function was observed more often in G2 than in G1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0121_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Thyroid function was more often affected adversely in pregnancies complicated with preeclampsia than with gestational hypertension. Based on the results of our study it might be prudent to check thyroid hormones in\u00a0all asymptomatic pregnancies with preeclampsia or gestational hypertension. These findings need confirmation in larger better designed prospective studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2022-0121","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T23:11:20Z","timestamp":1653347480000},"page":"904-909","source":"Crossref","is-referenced-by-count":7,"title":["Association between maternal thyroid function and risk of gestational hypertension and preeclampsia"],"prefix":"10.1515","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2357-9580","authenticated-orcid":false,"given":"Edin","family":"Medjedovic","sequence":"first","affiliation":[{"name":"Clinic of Gynecology and Obstetrics , Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina"},{"name":"Department of Gynecology, Obstetrics and Reproductive Medicine, School of Medicine , Sarajevo School of Science and Technology , Sarajevo , Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Stanojevic","sequence":"additional","affiliation":[{"name":"Medical School University of Zagreb , Zagreb , Croatia"},{"name":"Department of Obstetrics and Gynecology , University hospital \u201cSveti Duh\u201d , Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Kurjak","sequence":"additional","affiliation":[{"name":"Medical School University of Zagreb , Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edin","family":"Begic","sequence":"additional","affiliation":[{"name":"Department of Cardiology , General Hospital \u201cPrim.Dr. Abdulah Nakas\u201d , Sarajevo , Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer","family":"Iglica","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Clinic for Heart, Blood Vessel and Rheumatic Diseases , Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabaheta","family":"Jonuzovic-Prosic","sequence":"additional","affiliation":[{"name":"Clinic of Gynecology and Obstetrics , Clinical Center University of Sarajevo , Sarajevo , Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"2023040100081888984_j_jpm-2022-0121_ref_001","doi-asserted-by":"crossref","unstructured":"Springer, D, Jiskra, J, Limanova, Z, Zima, T, Potlukova, E. Thyroid in pregnancy: from physiology to screening. Crit Rev Clin Lab Sci 2017;54:102\u201316. https:\/\/doi.org\/10.1080\/10408363.2016.1269309.","DOI":"10.1080\/10408363.2016.1269309"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_002","doi-asserted-by":"crossref","unstructured":"Stagnaro-Green, A, Pearce, E. Thyroid disorders in pregnancy. Nat Rev Endocrinol 2012;8:650\u20138. https:\/\/doi.org\/10.1038\/nrendo.2012.171.","DOI":"10.1038\/nrendo.2012.171"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_003","unstructured":"Singh, S, Sandhu, S. Thyroid Disease and Pregnancy. 2021 Jul 25, In: StatPearls, [Internet]. Treasure Island (FL): StatPearls Publishing; 2021."},{"key":"2023040100081888984_j_jpm-2022-0121_ref_004","unstructured":"Vukovic Babic, M, Habek, D, Habek \u010cerkez, J. Perinatal epidemiological risk factors for preeclampsia. Acta Clin Croat 2015;54:9\u201313."},{"key":"2023040100081888984_j_jpm-2022-0121_ref_005","doi-asserted-by":"crossref","unstructured":"Wright, D, Wright, A, Nicolaides, KH. The competing risk approach for prediction of preeclampsia. Am J Obstet Gynecol 2020;223:12\u201323.e7. https:\/\/doi.org\/10.1016\/j.ajog.2019.11.1247.","DOI":"10.1016\/j.ajog.2019.11.1247"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_006","doi-asserted-by":"crossref","unstructured":"Paula, LG, Pinheiro da Costa, BE, Hentschke, MR, Antonello, IC, Luz, JH, da Cunha Filho, EV, et al.. Increased proteinuria and uric acid levels are associated with eclamptic crisis. Pregnancy Hypertens 2019;15:93\u20137. https:\/\/doi.org\/10.1016\/j.preghy.2018.12.003.","DOI":"10.1016\/j.preghy.2018.12.003"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_007","doi-asserted-by":"crossref","unstructured":"Gestational hypertension and preeclampsia: ACOG practice bulletin summary, number 222. Obstet Gynecol 2020;135:e237\u201360. https:\/\/doi.org\/10.1097\/AOG.0000000000003892.","DOI":"10.1097\/AOG.0000000000003891"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_008","doi-asserted-by":"crossref","unstructured":"Nazarpour, S, Ramezani Tehrani, F, Simbar, M, Tohidi, M, Alavi Majd, H, Azizi, F, et al.. Effects of levothyroxine treatment on pregnancy outcomes in pregnant women with autoimmune thyroid disease. Eur J Endocrinol 2017;176:253\u201365. https:\/\/doi.org\/10.1530\/EJE-16-0548.","DOI":"10.1530\/EJE-16-0548"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_009","doi-asserted-by":"crossref","unstructured":"Medjedovic, E, Suljevic, A, Iglica, A, Rama, A, Mahmutbegovic, E, Muftic, A, et al.. Uric acid values along with Doppler sonography findings as a tool for preeclampsia screening. Med Arch 2019;73:408\u201311. https:\/\/doi.org\/10.5455\/medarh.2019.73.408-411.","DOI":"10.5455\/medarh.2019.73.408-411"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_010","doi-asserted-by":"crossref","unstructured":"Han, Y, Wang, J, Wang, X, Ouyang, L, Li, Y. Relationship between subclinical hypothyroidism in pregnancy and hypertensive disorder of pregnancy: a systematic review and meta-analysis. Front Endocrinol 2022;13:823710. https:\/\/doi.org\/10.3389\/fendo.2022.823710.","DOI":"10.3389\/fendo.2022.823710"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_011","doi-asserted-by":"crossref","unstructured":"Toloza, FJK, Derakhshan, A, M\u00e4nnist\u00f6, T, Bliddal, S, Popova, PV, Carty, DM, et al.. Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol 2022;10:243\u201352. https:\/\/doi.org\/10.1016\/S2213-8587(22)00007-9.","DOI":"10.1016\/S2213-8587(22)00007-9"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_012","doi-asserted-by":"crossref","unstructured":"Lai, H, Zhan, ZY, Liu, H. Association between thyroid hormone parameters during early pregnancy and gestational hypertension: a prospective cohort study. J Int Med Res 2020;48:300060520904814.","DOI":"10.1177\/0300060520904814"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_013","doi-asserted-by":"crossref","unstructured":"Chen, J, Gao, Q, Jiang, L, Feng, X, Zhu, X, Fan, X, et al.. The NOX2-derived reactive oxygen species damaged endothelial nitric oxide system via suppressed BKCa\/SKCa in preeclampsia. Hypertens Res 2017;40:457\u201364. https:\/\/doi.org\/10.1038\/hr.2016.180.","DOI":"10.1038\/hr.2016.180"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_014","doi-asserted-by":"crossref","unstructured":"Kim, HJ, Cho, YY, Kim, SW, Kim, TH, Jang, HW, Lee, SY, et al.. Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area. Korean J Intern Med (Korean Ed) 2018;33:552\u201360. https:\/\/doi.org\/10.3904\/kjim.2016.051.","DOI":"10.3904\/kjim.2016.051"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_015","doi-asserted-by":"crossref","unstructured":"Ives, CW, Sinkey, R, Rajapreyar, I, Tita, ATN, Oparil, S. Preeclampsia-pathophysiology and clinical presentations: JACC state-of-the-art review. J Am Coll Cardiol 2020;76:1690\u2013702. https:\/\/doi.org\/10.1016\/j.jacc.2020.08.014.","DOI":"10.1016\/j.jacc.2020.08.014"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_016","doi-asserted-by":"crossref","unstructured":"Stagnaro-Green, A, Abalovich, M, Alexander, E, Azizi, F, Mestman, J, Negro, R, et al.. American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid 2011;21:1081\u2013125. https:\/\/doi.org\/10.1089\/thy.2011.0087.","DOI":"10.1089\/thy.2011.0087"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_017","doi-asserted-by":"crossref","unstructured":"Abbassi-Ghanavati, M, Greer, LG, Cunningham, FG. Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol 2009;114:1326\u201331. https:\/\/doi.org\/10.1097\/AOG.0b013e3181c2bde8.","DOI":"10.1097\/AOG.0b013e3181c2bde8"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_018","doi-asserted-by":"crossref","unstructured":"Shields, B, Hill, A, Bilous, M, Knight, B, Hattersley, AT, Bilous, RW, et al.. Cigarette smoking during pregnancy is associated with alterations in maternal and fetal thyroid function. J Clin Endocrinol Metab 2009;94:570\u20134. https:\/\/doi.org\/10.1210\/jc.2008-0380.","DOI":"10.1210\/jc.2008-0380"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_019","doi-asserted-by":"crossref","unstructured":"Gui, J, Xu, W, Zhang, J. Association between thyroid dysfunction and perinatal outcomes in women with gestational hypertension: a retrospective study. BMC Pregnancy Childbirth 2020;20:119. https:\/\/doi.org\/10.1186\/s12884-020-2805-6.","DOI":"10.1186\/s12884-020-2805-6"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_020","doi-asserted-by":"crossref","unstructured":"Saki, F, Dabbaghmanesh, MH, Ghaemi, SZ, Forouhari, S, Ranjbar Omrani, G, Bakhshayeshkaram, M. Thyroid function in pregnancy and its influences on maternal and fetal outcomes. Int J Endocrinol Metabol 2014;12:e19378. https:\/\/doi.org\/10.5812\/ijem.19378.","DOI":"10.5812\/ijem.19378"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_021","doi-asserted-by":"crossref","unstructured":"Businge, CB, Longo-Mbenza, B, Kengne, AP. Mildly elevated thyroid-stimulating hormone is associated with endothelial dysfunction and severe preeclampsia among pregnant women with insufficient iodine intake in Eastern Cape province, South Africa. Ann Med 2021;53:1083\u20139. https:\/\/doi.org\/10.1080\/07853890.2021.1947520.","DOI":"10.1080\/07853890.2021.1947520"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_022","doi-asserted-by":"crossref","unstructured":"Wang, J, Gong, XH, Peng, T, Wu, JN. Association of thyroid function during pregnancy with the risk of pre-eclampsia and gestational diabetes mellitus. Endocr Pract 2021;27:819\u201325. https:\/\/doi.org\/10.1016\/j.eprac.2021.03.014.","DOI":"10.1016\/j.eprac.2021.03.014"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_023","doi-asserted-by":"crossref","unstructured":"Wilson, KL, Casey, BM, McIntire, DD, Halvorson, LM, Cunningham, FG. Subclinical thyroid disease and the incidence of hypertension in pregnancy. Obstet Gynecol 2012;119:315\u201320. https:\/\/doi.org\/10.1097\/AOG.0b013e318240de6a.","DOI":"10.1097\/AOG.0b013e318240de6a"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_024","unstructured":"Davis, LE, Leveno, KJ, Cunningham, FG. Hypothyroidism complicating pregnancy. Obstet Gynecol 1988;72:108\u201312."},{"key":"2023040100081888984_j_jpm-2022-0121_ref_025","doi-asserted-by":"crossref","unstructured":"Alavi, A, Adabi, K, Nekuie, S, Jahromi, EK, Solati, M, Sobhani, A, et al.. Thyroid dysfunction and autoantibodies association with hypertensive disorders during pregnancy. J Pregnancy 2012;2012:742695. https:\/\/doi.org\/10.1155\/2012\/742695.","DOI":"10.1155\/2012\/742695"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_026","doi-asserted-by":"crossref","unstructured":"Lee, SY, Cabral, HJ, Aschengrau, A, Pearce, EN. Associations between maternal thyroid function in pregnancy and obstetric and perinatal outcomes. J Clin Endocrinol Metab 2020;105:e2015\u201323. https:\/\/doi.org\/10.1210\/clinem\/dgz275.","DOI":"10.1210\/clinem\/dgz275"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_027","doi-asserted-by":"crossref","unstructured":"Korevaar, TIM, Derakhshan, A, Taylor, PN, Meima, M, Chen, L, Bliddal, S, et al.. Consortium on Thyroid and Pregnancy\u2014Study Group on Preterm Birth. Association of thyroid function test abnormalities and thyroid autoimmunity with preterm birth: a systematic review and meta-analysis. JAMA 2019;322:632\u201341. https:\/\/doi.org\/10.1001\/jama.2019.10931.","DOI":"10.1001\/jama.2019.10931"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_028","doi-asserted-by":"crossref","unstructured":"Sitoris, G, Veltri, F, Kleynen, P, Cogan, A, Belhomme, J, Rozenberg, S, et al.. The impact of thyroid disorders on clinical pregnancy outcomes in a real-world study setting. Thyroid 2020;30:106\u201315. https:\/\/doi.org\/10.1089\/thy.2019.0199.","DOI":"10.1089\/thy.2019.0199"},{"key":"2023040100081888984_j_jpm-2022-0121_ref_029","doi-asserted-by":"crossref","unstructured":"Su, X, Liu, Y, Li, G, Liu, X, Huang, S, Duan, T, et al.. Associations of hypothyroxinemia with risk of preeclampsia-eclampsia and gestational hypertension. Front Endocrinol 2021;12:777152. https:\/\/doi.org\/10.3389\/fendo.2021.777152.","DOI":"10.3389\/fendo.2021.777152"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2022-0121\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2022-0121\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T14:00:52Z","timestamp":1680357652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2022-0121\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":29,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,5,25]]},"published-print":{"date-parts":[[2022,9,27]]}},"alternative-id":["10.1515\/jpm-2022-0121"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2022-0121","relation":{},"ISSN":["0300-5577","1619-3997"],"issn-type":[{"value":"0300-5577","type":"print"},{"value":"1619-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]}}}