{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:14:59Z","timestamp":1775481299896,"version":"3.50.1"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2022-0353_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Analyze the diagnostic and prognostic value of the sFlt-1\/PlGF ratio in pregnant women with at least one sign\/symptom of suspected\/diagnosed pre-eclampsia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0353_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective observational study included 170 pregnant women with at least one sign\/symptom of pre-eclampsia, who had sFlt-1\/PlGF ratio values. The following information was evaluated: pregnant women\u2019s demographic data and clinical history; laboratory data (urine protein\/creatinine ratio; sFlt-1\/PlGF ratio); signs and symptoms presented; clinical outcome; fetal complications; data related to childbirth. Statistical analysis was performed by R Software Version 3.5.2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0353_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 170 patients, 78 presented pre-eclampsia. The median sFlt-1\/PlGF ratio was significantly higher [143.1 (2.2\u20132,927.1)] for women who presented pre-eclampsia than for women without pre-eclampsia [33.5 (0.8\u2013400.2)]. The negative predictive value of sFlt-1\/PlGF ratio &lt;38 was 83.9\u202f% (95\u202f% CI, 71.7\u201392.4\u202f%) and the positive predictive value of sFlt-1\/PlGF ratio &gt;85 or 110 (for late onset pre-eclampsia) was 76.4\u202f% (95\u202f% CI, 66.2\u201384.8\u202f%). sFlt-1\/PlGF &gt;85 or 110 was associated with pre-eclampsia clinical development, fetal complications, shorter gestational age at birth, higher number of caesarean deliveries and lower birth weight.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0353_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The sFlt-1\/PlGF ratio, together with the standard diagnostic criteria, can be used to rule out pre-eclampsia, identify high-risk patients and predict the occurrence of adverse outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2022-0353","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T19:27:55Z","timestamp":1683746875000},"page":"896-903","source":"Crossref","is-referenced-by-count":8,"title":["The role of the soluble fms-like tyrosine kinase-1\/placental growth factor (sFlt-1\/PIGF)\u00a0\u2013 ratio in clinical practice in obstetrics: diagnostic and prognostic value"],"prefix":"10.1515","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1566-1250","authenticated-orcid":false,"given":"Daniela C.S.","family":"Melo","sequence":"first","affiliation":[{"name":"Department of Obstetrics-A , Coimbra Hospital and University Centre , Coimbra , Portugal"},{"name":"Faculty of Medicine, University of Coimbra , Coimbra , Portugal"},{"name":"University Clinic of Gynecology, Faculty of Medicine, University of Coimbra , Coimbra , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8144-8004","authenticated-orcid":false,"given":"Raquel P.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics-A , Coimbra Hospital and University Centre , Coimbra , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.J.D.R.","family":"Pais","sequence":"additional","affiliation":[{"name":"Department of Obstetrics-A , Coimbra Hospital and University Centre , Coimbra , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5373-5690","authenticated-orcid":false,"given":"Luiza M.","family":"Felix","sequence":"additional","affiliation":[{"name":"BlueClinal, Ltd , Matosinhos , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5321-2694","authenticated-orcid":false,"given":"Filipe F.","family":"Pinto","sequence":"additional","affiliation":[{"name":"BlueClinal, Ltd , Matosinhos , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 P.S.A.","family":"Moura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics-A , Coimbra Hospital and University Centre , Coimbra , Portugal"},{"name":"Faculty of Medicine, University of Coimbra , Coimbra , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"2023101805030552616_j_jpm-2022-0353_ref_001","doi-asserted-by":"crossref","unstructured":"Tranquilli, AL, Dekker, G, Magee, L, Roberts, J, Sibai, BM, Brown, MA, et al.. 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