{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:28:51Z","timestamp":1793424531853,"version":"4.5.0"},"reference-count":37,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2022-0379_abs_001\"><jats:title>Objectives<\/jats:title><jats:p>Shone\u2019s complex (SC) is characterized by sequential obstructions of left ventricular (LV) inflow and outflow. It can be associated with poor long-term prognosis when compared to Simple-Aortic Coarctation (S-CoA). We aimed to assess whether the degree of ventricular disproportion and 2D-speckle-tracking echocardiography (2D-STE) could improve the accuracy of prenatal prediction of SC.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2022-0379_abs_002\"><jats:title>Methods<\/jats:title><jats:p>75 consecutive fetuses were retrospectively enrolled from January 2010 to June 2021. Fetuses were divided into 4 groups (Group 1: SC; Group 2: S-CoA; Group 3: False Positive-Coarctation of the Aorta [FP-CoA]; group 4: controls). Comparisons for echocardiographic measures and myocardial deformation indices were performed. A receiver operating characteristic (ROC) analysis was performed on the MV\/TV (mitral valve\/tricuspid valve ratio) and LV GLS (global longitudinal strain) values to identify cut-offs to separate group 1 and 2 fetuses.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2022-0379_abs_003\"><jats:title>Results<\/jats:title><jats:p>SC fetuses showed a significant reduction in MV\/TV when compared to S-CoA and FP-CoA fetuses (p&lt;0.001). LV GLS in SC fetuses was significantly reduced compared to S-CoA fetuses (\u221213.3\u00a0\u00b1\u00a02.1% vs.\u00a0\u221217.0\u00a0\u00b1\u00a02.2%, p=0.001). A cut-off value of 0.59 for MV\/TV and\u00a0\u221215.35% for LV GLS yielded a sensitivity of 76 and 82% and a specificity of 71 and 83% respectively in separating SC vs. S-CoA fetuses.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2022-0379_abs_004\"><jats:title>Conclusions<\/jats:title><jats:p>SC fetuses showed a more severe degree of ventricular disproportion and a lower LV GLS compared to S-CoA, FP-CoA and control fetuses. MV\/TV and GLS are both predictors of SC. These findings may improve the quality of prenatal parental counselling.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2022-0379","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T20:08:26Z","timestamp":1669147706000},"page":"550-558","source":"Crossref","is-referenced-by-count":10,"title":["Prenatal prediction of Shone\u2019s complex. The role of the degree of ventricular disproportion and speckle-tracking analysis"],"prefix":"10.1515","volume":"51","author":[{"given":"Patrizio","family":"Moras","sequence":"first","affiliation":[{"name":"Perinatal Cardiology Unit, Department of Medical and Surgical for Fetus-Neonate , Bambino Ges\u00f9 Children\u2019s Hospital , Rome , Italy"},{"name":"Pediatric Department , University of Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Pasquini","sequence":"additional","affiliation":[{"name":"Perinatal Cardiology Unit, Department of Medical and Surgical for Fetus-Neonate , Bambino Ges\u00f9 Children\u2019s Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-4353","authenticated-orcid":false,"given":"Giuseppe","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fondazione Policlinico Tor Vergata , Universit\u00e0 Roma Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo Marco","family":"Campanale","sequence":"additional","affiliation":[{"name":"Perinatal Cardiology Unit, Department of Medical and Surgical for Fetus-Neonate , Bambino Ges\u00f9 Children\u2019s Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Masci","sequence":"additional","affiliation":[{"name":"Perinatal Cardiology Unit, Department of Medical and Surgical for Fetus-Neonate , Bambino Ges\u00f9 Children\u2019s Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Di Chiara","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Intensive Care Unit, Department of Pediatric Cardiology and Cardiac Surgery , Bambino Ges\u00f9 Children\u2019s Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Falasconi","sequence":"additional","affiliation":[{"name":"Vita-Salute University , San Raffaele, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Bagolan","sequence":"additional","affiliation":[{"name":"Neonatal Surgery Unit, Department of Medical and Surgical Neonatology , Ospedale Pediatrico Bambino Ges\u00f9 , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Toscano","sequence":"additional","affiliation":[{"name":"Perinatal Cardiology Unit, Department of Medical and Surgical for Fetus-Neonate , Bambino Ges\u00f9 Children\u2019s Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"2023050402001733977_j_jpm-2022-0379_ref_001","doi-asserted-by":"crossref","unstructured":"Shone, JD, Sellers, RD, Anderson, RC, Adams Jr, P, Lillhei, CW, Edwards, JE. 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