{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:02:16Z","timestamp":1793145736063,"version":"4.5.0"},"reference-count":129,"publisher":"Walter de Gruyter GmbH","issue":"1","funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["Contract No. HHSN275201300006C"],"award-info":[{"award-number":["Contract No. HHSN275201300006C"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00c3\u00a1nyos Akad\u00c3\u00a9mia","doi-asserted-by":"publisher","award":["Momentum Grant LP2014-7\/2014"],"award-info":[{"award-number":["Momentum Grant LP2014-7\/2014"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2022-0433_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The heterogeneous nature of preeclampsia is a major obstacle to early screening and prevention, and a molecular taxonomy of disease is needed. We have previously identified four subclasses of preeclampsia based on first-trimester plasma proteomic profiles. Herein, we expanded this approach by using a more comprehensive panel of proteins profiled in longitudinal samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2022-0433_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Proteomic data collected longitudinally from plasma samples of women who developed preeclampsia (n=109) and of controls (n=90) were available from our previous report on 1,125 proteins. Consensus clustering was performed to identify subgroups of patients with preeclampsia based on data from five gestational-age intervals by using select interval-specific features. Demographic, clinical, and proteomic differences among clusters were determined. Differentially abundant proteins were used to identify cluster-specific perturbed KEGG pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2022-0433_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four molecular clusters with different clinical phenotypes were discovered by longitudinal proteomic profiling. Cluster 1 involves metabolic and prothrombotic changes with high rates of early-onset preeclampsia and small-for-gestational-age neonates; Cluster 2 includes maternal anti-fetal rejection mechanisms and recurrent preeclampsia cases; Cluster 3 is associated with extracellular matrix regulation and comprises cases of mostly mild, late-onset preeclampsia; and Cluster 4 is characterized by angiogenic imbalance and a high prevalence of early-onset disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2022-0433_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study is an independent validation and further refining of molecular subclasses of preeclampsia identified by a different proteomic platform and study population. The results lay the groundwork for novel diagnostic and personalized tools of prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2022-0433","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T19:08:49Z","timestamp":1666033729000},"page":"51-68","source":"Crossref","is-referenced-by-count":36,"title":["Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention"],"prefix":"10.1515","volume":"51","author":[{"given":"N\u00e1ndor G\u00e1bor","family":"Than","sequence":"first","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services , Bethesda , Maryland, and Detroit, Michigan , USA"},{"name":"Systems Biology of Reproduction Research Group, Institute of Enzymology, Research Centre for Natural Sciences , Budapest , Hungary"},{"name":"Maternity Private Clinic of Obstetrics and Gynecology , Budapest , Hungary"},{"name":"Genesis Theranostix Group , Budapest , Hungary"},{"name":"First Department of Pathology and Experimental Cancer Research , Semmelweis University , Budapest , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services , Bethesda , Maryland, and Detroit, Michigan , USA"},{"name":"Department of Obstetrics and Gynecology , University of Michigan , Ann Arbor , Michigan , USA"},{"name":"Department of Epidemiology and Biostatistics , Michigan State University , East Lansing , Michigan , USA"},{"name":"Center for Molecular Medicine and Genetics, Wayne State University , Detroit , Michigan , USA"},{"name":"Detroit Medical Center , Detroit , Michigan , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel","family":"Gy\u00f6rffy","sequence":"additional","affiliation":[{"name":"Systems Biology of Reproduction Research Group, Institute of Enzymology, Research Centre for Natural Sciences , Budapest , Hungary"},{"name":"Genesis Theranostix Group , Budapest , Hungary"},{"name":"Faculty of Information Technology and Bionics , P\u00e1zm\u00e1ny P\u00e9ter Catholic University , Budapest , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9","family":"Posta","sequence":"additional","affiliation":[{"name":"Systems Biology of Reproduction Research Group, Institute of Enzymology, Research Centre for Natural Sciences , Budapest , 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