{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:32:30Z","timestamp":1789763550771,"version":"4.0.1"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2022-0452_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine the morphological characteristics of the placentas from COVID-19 positive mothers in regard to the trimester of COVID-19 infection onset and low weight molecular heparin (LMWH) treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0452_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Placentas were collected in the period April 1st till September 1st 2021 after delivery at Department of Obstetrics and Gynecology University Hospital Split, Croatia, and sent for pathological examination. Medical history and pathology reports were used to collect the data. Pregnant women were divided based on the onset of COVID-19 infection and stratified into low molecular weight heparin (LMWH)+ or LMWH\u2212. Depending on the data distribution, the following test were used: chi-squared test. Student\u2019s t-test, Mann-Whitney U test, ANOVA and Kruskal\u2013Wallis test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0452_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In 38% of patients the onset of COVID-19 infection was the 1st trimester of pregnancy, in 27% in the 2nd and 35% of women were infected in the 3rd trimester The fetal vascular malperfusion (FVM) occurrence was statistically significantly higher in the LMWH\u2212 group and if the onset of infection was in the 2nd trimester, while the perivillous fibrin deposition was most likely to happen if the COVID-19 infection that occured in the 1st trimester of pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0452_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The onset of COVID-19 infection has the influence on trophoblast damage and subsequent morphological appearance of the placenta. LMWH use in COVID positive pregnant women decreases the rate of the FVM in examined placentas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2022-0452","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T21:33:45Z","timestamp":1669325625000},"page":"607-613","source":"Crossref","is-referenced-by-count":8,"title":["Does COVID-19 infection acquired in different pregnancy trimester influence placental pathology?"],"prefix":"10.1515","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-652X","authenticated-orcid":false,"given":"Andrea","family":"Dagelic","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , University Hospital Centre Split , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedran","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Fetomaternal Medical Center, Department of Obstetrics and Gynecology , Helsinki University Hospital and University of Helsinki , Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasminka","family":"Resic Karara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University Hospital Centre Split , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Kuzmic Prusac","sequence":"additional","affiliation":[{"name":"Department of Pathology , University Hospital Centre Split , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damir","family":"Roje","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University Hospital Centre Split , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Kosovic","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University Hospital Centre Split , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Zekic Tomas","sequence":"additional","affiliation":[{"name":"Department of Pathology , University Hospital Centre Split , Split , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"2023060719030807491_j_jpm-2022-0452_ref_001","doi-asserted-by":"crossref","unstructured":"Lu, R, Zhao, X, Li, J, Niu, P, Yang, B, Wu, H. 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