{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:20:50Z","timestamp":1792758050680,"version":"4.5.0"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2022-0532_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine reference curves for fetal aortic and pulmonary valve annulus area by three-dimensional ultrasonography using the spatio-temporal image correlation (STIC) in the rendering mode, and to ascertain its applicability in congenital heart disease (CHD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0532_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a retrospective cross-sectional study of 328 normal fetuses and 42 fetuses with CHD between 20 and 33\u00a0weeks 6\u00a0days of gestation. The outflow plane view of the great vessels was used to measure the areas of the valvar annuli, and the measurements were performed in systole. A linear regression model adjusted according to the determination coefficient (R<jats:sup>2<\/jats:sup>) was utilized to construct the reference intervals. The concordance correlation coefficient (CCC) was used to calculate the reproducibility of the mitral and tricuspid valve areas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0532_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean\u00a0\u00b1\u00a0standard deviation (SD) of the aortic and pulmonary valve annulus areas ranged from 6.6\u00a0\u00b1\u00a01.2 to 32.9\u00a0\u00b1\u00a01.1\u00a0mm<jats:sup>2<\/jats:sup> and 10.7\u00a0\u00b1\u00a01.3 to 40.3\u00a0\u00b1\u00a01.2\u00a0mm<jats:sup>2<\/jats:sup>, respectively. We observed a linear relationship and strong positive correlation between the area of the aortic and pulmonary valve annuli with r=0.97 and 0.96, respectively. Good intra (CCC=0.99) and interobserver agreement (CCC=0.98) was observed for the measurement of the aortic valve annulus area. A good intra (CCC=0.99) and interobserver (CCC=0.97) agreement was also observed for the measurement of the pulmonary valve annulus area. The mean\u00a0\u00b1\u00a0SD of the difference of the areas of the aortic and pulmonary valve annuli between the normal fetuses and those with CHD were\u00a0\u22121.801\u00a0\u00b1\u00a01.429\u00a0mm<jats:sup>2<\/jats:sup> (p=0.208) and\u00a0\u22121.033\u00a0\u00b1\u00a01.467\u00a0mm<jats:sup>2<\/jats:sup> (p&lt;0.0001), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0532_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The reference curves for the areas of the aortic and pulmonary valve annuli of fetal hearts were determined, and showed good inter and intraobserver reproducibility. The constructed reference curves showed applicability in different types of CHD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2022-0532","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T20:35:27Z","timestamp":1672432527000},"page":"805-814","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of fetal heart aortic and pulmonary valve annulus area by three-dimensional ultrasonography: reference curves and applicability in congenital heart diseases"],"prefix":"10.1515","volume":"51","author":[{"given":"Caroline Cervante","family":"Chagas","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine , Federal University of S\u00e3o Paulo (EPM-UNIFESP) , S\u00e3o Paulo , SP , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Let\u00edcia","family":"Siqueira Pontes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine , Federal University of S\u00e3o Paulo (EPM-UNIFESP) , S\u00e3o Paulo , SP , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie Jeanne","family":"Bravo-Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology, School of Medicine , Federal University of Rio de Janeiro , Rio de Janeiro , RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Borges","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Service , Mario Palm\u00e9rio University Hospital\u00a0\u2013 University of Uberaba (UNIUBE) , Uberaba , MG , Brazil"},{"name":"Department of Obstetrics and Gynecology , Federal University of Tri\u00e2ngulo Mineiro (UFTM) , Uberaba , MG , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Mappa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata , Universit\u00e0 di Roma Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina","family":"Viscardi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata , Universit\u00e0 di Roma Tor Vergata , Rome , Italy"},{"name":"Department of Obstetrics and Gynecology , Universit\u00e0 di Bari , Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-4353","authenticated-orcid":false,"given":"Giuseppe","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata , Universit\u00e0 di Roma Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine , Federal University of S\u00e3o Paulo (EPM-UNIFESP) , S\u00e3o Paulo , SP , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,1,2]]},"reference":[{"key":"2023071316140739655_j_jpm-2022-0532_ref_001","doi-asserted-by":"crossref","unstructured":"Bravo-Valenzuela, NJ, Peixoto, AB, Araujo J\u00fanior, E. 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