{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:34:35Z","timestamp":1740141275385,"version":"3.37.3"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830041"],"award-info":[{"award-number":["81830041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High-level talents incubation plan scientific research project of Maternal and Child Health Care Hospital of Shandong Provincial, Cheeloo College of Medicine, Shandong University","award":["2022RS06"],"award-info":[{"award-number":["2022RS06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2022-0565_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Preeclampsia (PE) is a disease specific to pregnancy that causes 9\u201310\u202f% of maternal deaths. Early-onset PE (&lt;34 weeks\u2019 gestation) is the most dangerous category of PE. Wnt7a and GPR124 (G protein-coupled receptor 124) are widely expressed in the human reproductive process. Especially during embryogenesis and tumorigenesis, Wnt7a plays a crucial role. However, few studies have examined the association between Wnt7a-GPR124 and early-onset PE. The aim of this study was to examine the significance of Wnt7a and GPR124 in early-onset PE as well as Wnt7a\u2019s role in trophoblast cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0565_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Immunohistochemistry (IHC), real-time PCR, and western blotting (WB) were used to investigate Wnt7a and GPR124 expression in normal and early-onset PE placentas. Additionally, FACS, Transwell, and CCK-8 assays were used to diagnose Wnt7a involvement in migration, invasion, and proliferation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0565_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the early-onset PE group, Wnt7a and GPR124 expression was significantly lower than in the normal group, especially in the area of syncytiotrophoblasts (STBs) and extravillous trophoblasts (EVTs). A negative correlation was found between Wnt7a RNA and GPR124 expression (r=\u22120.42, p&lt;0.01). However, the Wnt7a RNA expression level was positive correlated with PE severity. In further cellular functional experiments, knockdown of Wnt7a inhibits HTR8\/SVeno cells invasion and migration but has little effect on proliferation and apoptosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2022-0565_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Through the Wnt pathway, Wnt7a regulates trophoblast cell invasion and migration, and may contribute to early-onset preeclampsia pathogenesis. A molecular level study of Wnt7a will be needed to find downstream proteins and mechanisms of interaction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2022-0565","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T09:40:41Z","timestamp":1694425241000},"page":"41-49","source":"Crossref","is-referenced-by-count":1,"title":["Down-regulated Wnt7a and GPR124 in early-onset preeclampsia placentas reduce invasion and migration of trophoblast cells"],"prefix":"10.1515","volume":"52","author":[{"given":"Yan","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Shenzhen Maternity and Child Healthcare Hospital, Cheeloo College of Medicine , Shandong University , Shenzhen , Guangdong , P.R. China"},{"name":"Department of Obstetrics and Gynaecology, Shandong Provincial Maternal and Child Health Care Hospital, Cheeloo College of Medicine , Shandong University , Jinan , P.R. China"},{"name":"Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China , Shandong Provincial Maternal and Child Health Care Hospital , Jinan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyu","family":"Cui","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital , Jinan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Shandong Provincial Maternal and Child Health Care Hospital, Cheeloo College of Medicine , Shandong University , Jinan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Shandong Provincial Maternal and Child Health Care Hospital, Cheeloo College of Medicine , Shandong University , Jinan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Shandong Provincial Maternal and Child Health Care Hospital, Cheeloo College of Medicine , Shandong University , Jinan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Shandong Provincial Maternal and Child Health Care Hospital, Cheeloo College of Medicine , Shandong University , Jinan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaowen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Shandong Provincial Maternal and Child Health Care Hospital, Cheeloo College of Medicine , Shandong University , Jinan , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmin","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Shenzhen Maternity and Child Healthcare Hospital, Cheeloo College of Medicine , Shandong University , Shenzhen , Guangdong , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"2024011107231759889_j_jpm-2022-0565_ref_001","doi-asserted-by":"crossref","unstructured":"Wilkerson, RG, Ogunbodede, AC. Hypertensive disorders of pregnancy. 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