{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:45:05Z","timestamp":1792593905353,"version":"4.5.0"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2023-0199_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Investigating the relationship between liver enzymes, uric acid (UA), and macrosomia will benefit physicians in the early detection of complications that may emerge during\/after pregnancy. The study analyzed liver enzyme activity and UA levels in first-trimester pregnant for\u00a0the risk of macrosomia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0199_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective cross-sectional research analyzed the data of pregnant women who gave birth between Jan 2021\u20132023. All data were extracted from medical records, and UA and AST-ALT were examined in all the participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0199_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were higher in the macrosomia (p&lt;0.05). Similarly, UA levels were higher in the macrosomia (p&lt;0.001). There was a moderate positive correlation between ALT and birth weight (r=0.168, p&lt;0.01), while we found a strong positive correlation between UA and birth weight (r=0.355, p&lt;0.01). In the ROC (receiver operating characteristic), Area Under the Curve (AUC) for ALT and UA was significant (p&lt;0.0001) but not for AST (p=0.157). UA showed a predictive value for macrosomia with 68.1\u202f% sensitivity and 63.8\u202f% specificity at a 3.15 cut-off (AUC:0.689; p:0.0001; CI:0.644\u20130.725).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0199_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These results indicate that ALT and UA may be potentially important in determining the risk of macrosomia. The UA had a more potent marker for macrosomia than ALT. The occurrence of macrosomia might be more closely related to the mother\u2019s metabolic syndrome rather than NAFLD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2023-0199","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T15:37:32Z","timestamp":1690299452000},"page":"1040-1045","source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive analysis of macrosomia: exploring the association between first-trimester alanine aminotransferase and uric acid measurements in pregnant women"],"prefix":"10.1515","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-3372","authenticated-orcid":false,"given":"Seyma Banu","family":"Arslanca","sequence":"first","affiliation":[{"name":"Department of Perinatology , Etlik City Hospital , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-3029","authenticated-orcid":false,"given":"Ali Turhan","family":"Caglar","sequence":"additional","affiliation":[{"name":"Department of Perinatology , Etlik City Hospital , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"2023100415421283016_j_jpm-2023-0199_ref_001","doi-asserted-by":"crossref","unstructured":"Allen, AM, Therneau, TM, Larson, JJ, Coward, A, Somers, VK, Kamath, PS. 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