{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:56:24Z","timestamp":1781794584976,"version":"3.54.5"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2023-0210_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The benefits of sildenafil by increasing blood flow in the improvement of Doppler parameters of umbilical (UA), uterine (UtA), and fetal middle cerebral arteries (MCA) remain uncertain. On the other hand, insufficient blood flow during uterine contractions in labor can lead to decrease blood supply and fetal distress. Therefore, we aimed to assess the changes in fetal Doppler indices and maternal and neonatal outcomes following the use of sildenafil in the active phase of labor in low-risk pregnancies with healthy fetuses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2023-0210_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized double-blinded controlled trial was conducted on 70 pregnant single low-risk, pregnant women. The patients were randomly assigned into two groups receiving sildenafil (n=35) or placebo (n=35) when the active phase of labor was initiated. Doppler parameters were assessed at baseline as well as 3\u202fh after that. Indeed, the maternal and neonatal outcomes were compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2023-0210_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Doppler parameters including the pulsatility index of MCA, UA, and left and right UtA remained unchanged after the administration of sildenafil. Neonatal outcomes including birth weight, PH of the umbilical artery, Apgar score, respiratory distress syndrome, and neonatal intensive care unit admission as well as maternal outcomes such as cesarean section rate and the occurrence of intrapartum\/postpartum hemorrhage had no difference between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2023-0210_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of sildenafil in the active phase of labor in low-risk pregnancies may not be beneficial in improving Doppler parameters in MCA, umbilical, and uterine arteries and thus may not improve pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2023-0210","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T13:21:28Z","timestamp":1699276888000},"page":"210-214","source":"Crossref","is-referenced-by-count":0,"title":["Effects of sildenafil on Doppler parameters, maternal and neonatal outcomes in the active labor phase of low-risk pregnancies: a randomized clinical trial"],"prefix":"10.1515","volume":"52","author":[{"given":"Vajiheh","family":"Marsosi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shariati Hospital , Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladan","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Shahid Akbarabadi Hospital , Iran University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parinaz Hamed","family":"Nasimi","sequence":"additional","affiliation":[{"name":"Shahid Akbarabadi Hospital , Iran University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Ghaemi","sequence":"additional","affiliation":[{"name":"Vali-E-Asr Reproductive Health Research Center , Family Health Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saimaz","family":"Navaee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shariati Hospital , Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"2026061814321969261_j_jpm-2023-0210_ref_001","doi-asserted-by":"crossref","unstructured":"Mandala, M, Osol, G. 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