{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:40:07Z","timestamp":1782567607165,"version":"3.54.5"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"name":"Kids of NYU Langone","award":["51-C49550-72475-NYUPRJ"],"award-info":[{"award-number":["51-C49550-72475-NYUPRJ"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2023-0243_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Near infrared spectroscopy (NIRS) is a non-invasive method for monitoring regional tissue oxygen saturation (rSO<jats:sub>2<\/jats:sub>). The purpose of this study is to investigate the changes that occur in cerebral, splanchnic, and renal rSO<jats:sub>2<\/jats:sub> and fractional tissue oxygen extraction (FTOE) in stable preterm infants in the first week of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0243_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Prospective observational study of infants born 30\u201334\u00a0weeks gestation at NYU Langone Health between November 2017 and November 2018. Cerebral, renal, and splanchnic rSO<jats:sub>2<\/jats:sub> were monitored from 12 to 72\u202fh of life, and\u00a0at\u00a0seven days. Subjects were divided into gestational age\u00a0(GA) cohorts. Average rSO<jats:sub>2<\/jats:sub>, splanchnic cerebral oxygen ratio\u00a0(SCOR), FTOE, and regional intra-subject variability was calculated at each location at five different time intervals: 0\u201312\u202fh, 12\u201324\u202fh, 24\u201348\u202fh, 48\u201372\u202fh, and one week of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0243_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty subjects were enrolled. The average cerebral rSO<jats:sub>2<\/jats:sub> ranged from 76.8 to 92.8\u202f%, renal rSO<jats:sub>2<\/jats:sub> from 65.1 to\u00a091.1\u202f%, and splanchnic rSO<jats:sub>2<\/jats:sub> from 36.1 to 76.3\u202f%. The SCOR ranged from 0.45 to 0.94. The strongest correlation between the GA cohorts was in the cerebral region (R<jats:sup>2<\/jats:sup>=0.94) and weakest correlation was in the splanchnic region (R<jats:sup>2<\/jats:sup>=0.81). The FTOE increased in all three locations over time. Intra-subject variability was lowest in the cerebral region (1.3\u202f% (\u00b11.9)).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0243_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The cerebral region showed the strongest correlation between GA cohorts and lowest intra-subject variability, making it the most suitable for clinical use when\u00a0monitoring for tissue hypoxia. Further studies are needed to further examine rSO<jats:sub>2<\/jats:sub> in preterm infants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2023-0243","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T10:10:50Z","timestamp":1709547050000},"page":"445-451","source":"Crossref","is-referenced-by-count":3,"title":["Changes in regional tissue oxygen saturation values during the first week of life in stable preterm infants"],"prefix":"10.1515","volume":"52","author":[{"given":"Sadaf H.","family":"Kazmi","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Hassenfeld Children\u2019s Hospital of New York University Langone Health Center , New York , NY , USA"},{"name":"New York University Grossman School of Medicine , New York , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourabh","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hassenfeld Children\u2019s Hospital of New York University Langone Health Center , New York , NY , USA"},{"name":"New York University Grossman School of Medicine , New York , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hassenfeld Children\u2019s Hospital of New York University Langone Health Center , New York , NY , USA"},{"name":"New York University Grossman School of Medicine , New York , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4743-2452","authenticated-orcid":false,"given":"Pradeep","family":"Mally","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hassenfeld Children\u2019s Hospital of New York University Langone Health Center , New York , NY , USA"},{"name":"New York University Grossman School of Medicine , New York , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnahamsi","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Hassenfeld Children\u2019s Hospital of New York University Langone Health Center , New York , NY , USA"},{"name":"New York University Grossman School of Medicine , New York , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"2024050315031380785_j_jpm-2023-0243_ref_001","doi-asserted-by":"crossref","unstructured":"Pichler, G, Cheung, PY, Aziz, K, Urlesberger, B, Schmolzer, GM. How to monitor the brain during immediate neonatal transition and resuscitation? A systematic qualitative review of the literature. Neonatology 2014;105:205\u201310. https:\/\/doi.org\/10.1159\/000357162.","DOI":"10.1159\/000357162"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_002","doi-asserted-by":"crossref","unstructured":"Sood, BG, McLaughlin, K, Cortez, J. Near-infrared spectroscopy: applications in neonates. Semin Fetal Neonatal Med 2015;20:164\u201372. https:\/\/doi.org\/10.1016\/j.siny.2015.03.008.","DOI":"10.1016\/j.siny.2015.03.008"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_003","doi-asserted-by":"crossref","unstructured":"Wijbenga, RG, Lemmers, PM, van Bel, F. Cerebral oxygenation during the first days of life in preterm and term neonates: differences between different brain regions. Pediatr Res 2011;70:389\u201394. https:\/\/doi.org\/10.1203\/pdr.0b013e31822a36db.","DOI":"10.1203\/PDR.0b013e31822a36db"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_004","doi-asserted-by":"crossref","unstructured":"Van Bel, F, Lemmers, P, Naulaers, G. Monitoring neonatal regional cerebral oxygen saturation in clinical practice: value and pitfalls. Neonatology 2008;94:237\u201344. https:\/\/doi.org\/10.1159\/000151642.","DOI":"10.1159\/000151642"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_005","doi-asserted-by":"crossref","unstructured":"Binder, C, Urlesberger, B, Avian, A, Pocivalnik, M, Muller, W, Pichler, G. Cerebral and peripheral regional oxygen saturation during postnatal transition in preterm neonates. J Pediatr 2013;163:394\u20139. https:\/\/doi.org\/10.1016\/j.jpeds.2013.01.026.","DOI":"10.1016\/j.jpeds.2013.01.026"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_006","doi-asserted-by":"crossref","unstructured":"Takami, T, Sunohara, D, Kondo, A, Mizukaki, N, Suganami, Y, Takei, Y, et al.. Changes in cerebral perfusion in extremely LBW infants during the first 72\u202fh after birth. Pediatr Res 2010;68:435\u20139. https:\/\/doi.org\/10.1203\/PDR.0b013e3181f2bd4d.","DOI":"10.1203\/PDR.0b013e3181f2bd4d"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_007","doi-asserted-by":"crossref","unstructured":"Urlesberger, B, Grossauer, K, Pocivalnik, M, Avian, A, Muller, W, Pichler, G. Regional oxygen saturation of the brain and peripheral tissue during birth transition of term infants. J Pediatr 2010;157:740\u20134. https:\/\/doi.org\/10.1016\/j.jpeds.2010.05.013.","DOI":"10.1016\/j.jpeds.2010.05.013"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_008","doi-asserted-by":"crossref","unstructured":"Urlesberger, B, Kratky, E, Rehak, T, Pocivalnik, M, Avian, A, Czihak, J, et al.. Regional oxygen saturation of the brain during birth transition of term infants: comparison between elective cesarean and vaginal deliveries. J Pediatr 2011;159:404\u20138. https:\/\/doi.org\/10.1016\/j.jpeds.2011.02.030.","DOI":"10.1016\/j.jpeds.2011.02.030"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_009","doi-asserted-by":"crossref","unstructured":"Almaazmi, M, Schmid, MB, Havers, S, Reister, F, Lindner, W, Mayer, B, et al.. Cerebral near-infrared spectroscopy during transition of healthy term newborns. Neonatology 2013;103:246\u201351. https:\/\/doi.org\/10.1159\/000345926.","DOI":"10.1159\/000345926"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_010","doi-asserted-by":"crossref","unstructured":"Bailey, SM, Hendricks-Munoz, KD, Mally, P. Splanchnic-cerebral oxygenation ratio (SCOR) values in healthy term infants as measured by near-infrared spectroscopy (NIRS). Pediatr Surg Int 2013;29:591\u20135. https:\/\/doi.org\/10.1007\/s00383-013-3285-9.","DOI":"10.1007\/s00383-013-3285-9"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_011","doi-asserted-by":"crossref","unstructured":"Fuchs, H, Lindner, W, Buschko, A, Almazam, M, Hummler, HD, Schmid, MB. Brain oxygenation monitoring during neonatal resuscitation of very low birth weight infants. J Perinatol 2012;32:356\u201362. https:\/\/doi.org\/10.1038\/jp.2011.110.","DOI":"10.1038\/jp.2011.110"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_012","doi-asserted-by":"crossref","unstructured":"Fauchere, JC, Schulz, G, Haensse, D, Keller, E, Ersch, J, Bucher, HU, et al.. Near-infrared spectroscopy measurements of cerebral oxygenation in newborns during immediate postnatal adaptation. J Pediatr 2010;156:372\u20136. https:\/\/doi.org\/10.1016\/j.jpeds.2009.09.050.","DOI":"10.1016\/j.jpeds.2009.09.050"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_013","doi-asserted-by":"crossref","unstructured":"Pichler, G, Binder, C, Avian, A, Beckenbach, E, Schmolzer, GM, Urlesberger, B. Reference ranges for regional cerebral tissue oxygen saturation and fractional oxygen extraction in neonates during immediate transition after birth. J Pediatr 2013;163:1558\u201363. https:\/\/doi.org\/10.1016\/j.jpeds.2013.07.007.","DOI":"10.1016\/j.jpeds.2013.07.007"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_014","doi-asserted-by":"crossref","unstructured":"Baik, N, Urlesberger, B, Schwaberger, B, Schmolzer, GM, Mileder, L, Avian, A, et al.. Reference ranges for cerebral tissue oxygen saturation index in term neonates during immediate neonatal transition after birth. Neonatology 2015;108:283\u20136. https:\/\/doi.org\/10.1159\/000438450.","DOI":"10.1159\/000438450"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_015","doi-asserted-by":"crossref","unstructured":"Fortune, PM, Wagstaff, M, Petros, AJ. Cerebro-splanchnic oxygenation ratio (CSOR) using near infrared spectroscopy may be able to predict splanchnic ischaemia in neonates. Intensive Care Med 2001;27:1401\u20137. https:\/\/doi.org\/10.1007\/s001340100994.","DOI":"10.1007\/s001340100994"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_016","doi-asserted-by":"crossref","unstructured":"Dani, C, Pratesi, S, Fontanelli, G, Barp, J, Bertini, G. Blood transfusions increase cerebral, splanchnic, and renal oxygenation in anemic preterm infants. Transfusion 2010;50:1220\u20136. https:\/\/doi.org\/10.1111\/j.1537-2995.2009.02575.x.","DOI":"10.1111\/j.1537-2995.2009.02575.x"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_017","doi-asserted-by":"crossref","unstructured":"Bozzetti, V, Paterlini, G, Bel, F, Visser, GH, Tosetti, L, Gazzolo, D, et al.. Cerebral and somatic NIRS-determined oxygenation in IUGR preterm infants during transition. J Matern Fetal Neonatal Med 2016;29:443\u20136. https:\/\/doi.org\/10.3109\/14767058.2014.1003539.","DOI":"10.3109\/14767058.2014.1003539"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_018","doi-asserted-by":"crossref","unstructured":"Schat, TE, Schurink, M, van der Laan, ME, Hulscher, JB, Hulzebos, CV, Bos, AF, et al.. Near-infrared spectroscopy to predict the course of necrotizing enterocolitis. PLoS One 2016;11:e0154710. https:\/\/doi.org\/10.1371\/journal.pone.0154710.","DOI":"10.1371\/journal.pone.0154710"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_019","doi-asserted-by":"crossref","unstructured":"Bailey, SM, Hendricks-Munoz, KD, Mally, P. Splanchnic-cerebral oxygenation ratio as a marker of preterm infant blood transfusion needs. Transfusion 2012;52:252\u201360. https:\/\/doi.org\/10.1111\/j.1537-2995.2011.03263.x.","DOI":"10.1111\/j.1537-2995.2011.03263.x"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_020","doi-asserted-by":"crossref","unstructured":"Corvaglia, L, Martini, S, Battistini, B, Rucci, P, Faldella, G, Aceti, A. Splanchnic oxygenation at first enteral feeding in preterm infants: correlation with feeding intolerance. J Pediatr Gastroenterol Nutr 2017;64:550\u20134. https:\/\/doi.org\/10.1097\/mpg.0000000000001308.","DOI":"10.1097\/MPG.0000000000001308"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_021","doi-asserted-by":"crossref","unstructured":"Pellicer, A, Greisen, G, Benders, M, Claris, O, Dempsey, E, Fumagalli, M, et al.. The SafeBoosC phase II randomised clinical trial: a treatment guideline for targeted near-infrared-derived cerebral tissue oxygenation vs. standard treatment in extremely preterm infants. Neonatology 2013;104:171\u20138. https:\/\/doi.org\/10.1159\/000351346.","DOI":"10.1159\/000351346"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_022","doi-asserted-by":"crossref","unstructured":"Lemmers, PM, Toet, M, van Schelven, LJ, van Bel, F. Cerebral oxygenation and cerebral oxygen extraction in the preterm infant: the impact of respiratory distress syndrome. Exp Brain Res 2006;173:458\u201367. https:\/\/doi.org\/10.1007\/s00221-006-0388-8.","DOI":"10.1007\/s00221-006-0388-8"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_023","doi-asserted-by":"crossref","unstructured":"Franceschini, MA, Thaker, S, Themelis, G, Krishnamoorthy, KK, Bortfeld, H, Diamond, SG, et al.. Assessment of infant brain development with frequency-domain near-infrared spectroscopy. Pediatr Res 2007;61:546\u201351. https:\/\/doi.org\/10.1203\/pdr.0b013e318045be99.","DOI":"10.1203\/pdr.0b013e318045be99"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_024","doi-asserted-by":"crossref","unstructured":"Marin, T, Williams, BL, Mansuri, A, Mundy, C, Cockfield, C, Mann, PC, et al.. Renal oxygenation (rSO2) population parameter estimates in premature infants routinely monitored with near-infrared spectroscopy. Adv Neonatal Care 2022;22:370\u20137. https:\/\/doi.org\/10.1097\/anc.0000000000000927.","DOI":"10.1097\/ANC.0000000000000927"},{"key":"2024050315031380785_j_jpm-2023-0243_ref_025","doi-asserted-by":"crossref","unstructured":"McNeill, S, Gatenby, JC, McElroy, S, Engelhardt, B. Normal cerebral, renal and abdominal regional oxygen saturations using near-infrared spectroscopy in preterm infants. J Perinatol 2011;31:51\u20137. https:\/\/doi.org\/10.1038\/jp.2010.71.","DOI":"10.1038\/jp.2010.71"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2023-0243\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2023-0243\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T15:03:42Z","timestamp":1714748622000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2023-0243\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,5]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,3,27]]},"published-print":{"date-parts":[[2024,5,27]]}},"alternative-id":["10.1515\/jpm-2023-0243"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2023-0243","relation":{},"ISSN":["0300-5577","1619-3997"],"issn-type":[{"value":"0300-5577","type":"print"},{"value":"1619-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,5]]}}}