{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:50:36Z","timestamp":1790963436391,"version":"4.1.0"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"name":"Italian Ministry of University and Research","award":["MUR PE00000006 MNESYS PNRR"],"award-info":[{"award-number":["MUR PE00000006 MNESYS PNRR"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2023-0487_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate midbrain growth, including corpus callusum (CC) and cerebellar vermis (CV) and cortical development in late fetal growth restricted (FGR) subclassified according to the umbilical vein blood flow (UVBF) values.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0487_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a prospective study on singleton fetuses late FGR with abnormal placental cerebral ratio (PCR). FGR fetuses were further subdivided into normal (\u2265fifth centile) and abnormal (&lt;fifth centile) UVBF blood flow corrected for\u00a0AC (UVBF\/AC), neurosonography was performed at 33\u201334\u00a0weeks of gestation to assess CC and CV lengths and the depth of Sylvian fissure (SF), parieto-occipital (POF) and calcarine fissures (CF). Neurosonographic variables were normalized for fetal head circumference size.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0487_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study cohort included 60 late FGR, 31 with normal UVBF\/AC and 29 with abnormal UVBF\/AC values. The latter group showed significant differences in CC (median (interquartile range (IQR) normal 0.96 (0.73\u20131.16) vs. abnormal UVBF\/AC 0.60 (0.47\u20130.87); p&lt;0.0001)), CV (normal 1.04 (0.75\u20131.26) vs. abnormal UVBF (AC 0.76 (0.62\u20131.18)); p=0.0319), SF (normal 0.83 (0.74\u20130.93) vs. abnormal UVBF\/AC 0.56 (0.46\u20130.68); p&lt;0.0001), POF (normal 0.80 (0.71\u20130.90) vs. abnormal UVBF\/AC l 0.49 (0.39\u20130.90); p\u22640.0072) and CF\u00a0(normal 0.83 (0.56\u20131.01) vs. abnormal UVBF\/AC 0.72 (0.53\u20130.80); p&lt;0.029).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0487_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Late onset FGR fetuses with of reduced umbilical vein flow showed shorter CC and CV length and a delayed cortical development when compared to those with normal umbilical vein hemodynamics. These findings support the existence of a link between abnormal brain development and changes in umbilical vein circulation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2023-0487","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T01:20:30Z","timestamp":1706664030000},"page":"423-428","source":"Crossref","is-referenced-by-count":7,"title":["Effects of umbilical vein flow on midbrain growth and cortical development in late onset fetal growth restricted fetuses: a prospective cross-sectional study"],"prefix":"10.1515","volume":"52","author":[{"given":"Ilenia","family":"Mappa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata , Universit\u00e0 di Roma Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata , Universit\u00e0 di Roma Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Pietrolucci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata , Universit\u00e0 di Roma Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Li","family":"Angela Lu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata , Universit\u00e0 di Roma Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Universit\u00e0 di Chieti , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-4353","authenticated-orcid":false,"given":"Giuseppe","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata , Universit\u00e0 di Roma Tor Vergata , Rome , Italy"},{"name":"Department of Obstetrics and Gynecology , Universit\u00e0 di Chieti , Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"2024050315031393984_j_jpm-2023-0487_ref_001","doi-asserted-by":"crossref","unstructured":"Arcangeli, T, Thilaganathan, B, Hooper, R, Khan, KS, Bhide, A. 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