{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:21:39Z","timestamp":1767183699479},"reference-count":9,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2023-0499_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate associations between serum analytes used for genetic screening and obstetric complications among twin pregnancies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0499_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cohort included twins delivered at a tertiary care hospital from 2009 to 2017. Abnormal levels of pregnancy associated plasma protein (PAPP-A), first and second trimester human chorionic gonadotropin (hCG), alpha fetoprotein (AFP), estriol, and inhibin, reported as multiples of the median (MoM), were defined as &lt;5\u202f%ile or &gt;95\u202f%ile for our cohort. Associations between abnormal analytes and preterm delivery, small for gestational age, and pregnancy-associated hypertension were calculated using Fisher\u2019s exact test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0499_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 357 dichorionic\/diamniotic and 123 monochorionic\/diamniotic twins were included. Among dichorionic\/diamniotic twins, elevated AFP (&gt;3.70 MoM) was associated with increased preterm delivery &lt;34\u00a0weeks (44.4 vs. 16.5\u202f%, p=0.007), while elevated inhibin (&gt;4.95 MoM) was associated with increased preterm delivery&lt;37\u00a0weeks (94.1 vs. 58.8\u202f%, p=0.004). For monochorionic\/diamniotic twins, elevated inhibin (&gt;6.34 MoM) was associated increased preterm delivery &lt;34\u00a0weeks (66.7 vs. 24.8\u202f%, p=0.04) and hypertension (66.7 vs. 21.4\u202f%, p=0.03).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0499_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Selected abnormal analyte levels were associated with increased rates of adverse outcomes in twin pregnancies, which differed by chorionicity. Our findings assist providers in interpreting abnormal analyte levels in twin pregnancies and may help to identify those at increased risk for adverse outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2023-0499","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T14:14:00Z","timestamp":1713449640000},"page":"586-590","source":"Crossref","is-referenced-by-count":1,"title":["Association between aneuploidy screening analytes and adverse outcomes in twin gestations"],"prefix":"10.1515","volume":"52","author":[{"given":"Kelly","family":"Yamasato","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Women\u2019s Health , University of Hawai\u2019i at Manoa John A Burns School of Medicine , Honolulu , HI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiwa","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Women\u2019s Health , University of Hawai\u2019i at Manoa John A Burns School of Medicine , Honolulu , HI , USA"},{"name":"New York-Presbyterian Queens , Flushing , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"2024071212145411318_j_jpm-2023-0499_ref_001","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and GynecologistsCommittee on GeneticsSociety for Maternal-Fetal Medicine. Screening for fetal chromosomal abnormalities: ACOG practice bulletin, number 226. Obstet Gynecol 2020;136:e48\u201369. https:\/\/doi.org\/10.1097\/aog.0000000000004084.","DOI":"10.1097\/AOG.0000000000004084"},{"key":"2024071212145411318_j_jpm-2023-0499_ref_002","doi-asserted-by":"crossref","unstructured":"Dugoff, L, Society for Maternal Fetal Medicine. First- and second-trimester maternal serum markers for aneuploidy and adverse obstetric outcomes. Obstet Gynecol 2010;115:1052\u201361. https:\/\/doi.org\/10.1097\/aog.0b013e3181da93da.","DOI":"10.1097\/AOG.0b013e3181da93da"},{"key":"2024071212145411318_j_jpm-2023-0499_ref_003","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists. Multifetal gestations: twin, triplet, and higher-order multifetal pregnancies: ACOG practice bulletin, number 231. Obstet Gynecol 2021;137:e145\u201362.","DOI":"10.1097\/AOG.0000000000004397"},{"key":"2024071212145411318_j_jpm-2023-0499_ref_004","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists. Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222. Obstet Gynecol 2020;135:e237\u201360.","DOI":"10.1097\/AOG.0000000000003891"},{"key":"2024071212145411318_j_jpm-2023-0499_ref_005","doi-asserted-by":"crossref","unstructured":"Talge, NM, Mudd, LM, Sikorskii, A, Basso, O. United States birth weight reference corrected for implausible gestational age estimates. Pediatrics 2014;133:844\u201353. https:\/\/doi.org\/10.1542\/peds.2013-3285.","DOI":"10.1542\/peds.2013-3285"},{"key":"2024071212145411318_j_jpm-2023-0499_ref_006","doi-asserted-by":"crossref","unstructured":"Rosner, JY, Fox, NS, Saltzman, D, Klauser, CK, Rebarber, A, Gupta, S. Abnormal biochemical analytes used for aneuploidy screening and adverse pregnancy outcomes in twin gestations. Am J Perinatol 2015;32:1331\u20135. https:\/\/doi.org\/10.1055\/s-0035-1564428.","DOI":"10.1055\/s-0035-1564428"},{"key":"2024071212145411318_j_jpm-2023-0499_ref_007","unstructured":"Chasen, ST, Martinucci, S, Perni, SC, Kalish, RB. First-trimester biochemistry and outcomes in twin pregnancy. J Reprod Med 2009;54:312\u20134."},{"key":"2024071212145411318_j_jpm-2023-0499_ref_008","doi-asserted-by":"crossref","unstructured":"Iskender, C, Tarim, E, Cok, T, Yalcinkaya, C, Kalayci, H, Yanik, FB. Obstetrical complications associated with first-trimester screening markers in twin pregnancies. J Obstet Gynaecol Res 2013;39:1495\u20139. https:\/\/doi.org\/10.1111\/jog.12091.","DOI":"10.1111\/jog.12091"},{"key":"2024071212145411318_j_jpm-2023-0499_ref_009","doi-asserted-by":"crossref","unstructured":"Lepage, N, Chitayat, D, Kingdom, J, Huang, T. Association between second-trimester isolated high maternal serum maternal serum human chorionic gonadotropin levels and obstetric complications in singleton and twin pregnancies. Am J Obstet Gynecol 2003;188:1354\u20139. https:\/\/doi.org\/10.1067\/mob.2003.278.","DOI":"10.1067\/mob.2003.278"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2023-0499\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2023-0499\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T12:17:24Z","timestamp":1720786644000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2023-0499\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,19]]},"references-count":9,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,5,10]]},"published-print":{"date-parts":[[2024,7,26]]}},"alternative-id":["10.1515\/jpm-2023-0499"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2023-0499","relation":{},"ISSN":["0300-5577","1619-3997"],"issn-type":[{"value":"0300-5577","type":"print"},{"value":"1619-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,19]]}}}