{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:50:39Z","timestamp":1747198239437,"version":"3.40.5"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2023-0528_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine if infants with exomphalos had abnormal antenatal lung growth as indicated by lower chest radiographic thoracic areas (CRTA) on day one compared to controls and whether the CRTA could predict the development of bronchopulmonary dysplasia (BPD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0528_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Infants with exomphalos cared for between January 2004 and January 2023 were included. The controls were term, newborn infants ventilated for absent respiratory drive at birth, without lung disease and had no supplemental oxygen requirement by 6\u202fh of age. The radiographs were imported as digital image files by Sectra PACS software (Sectra AB, Link\u00f6ping, Sweden). Free-hand tracing of the perimeter of the thoracic area was undertaken and the CRTA calculated by the software.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0528_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Sixty-four infants with exomphalos and 130 controls were included. Infants with exomphalos had a lower median (IQR) CRTA (1,983 [1,657\u20132,471]\u202fmm<jats:sup>2<\/jats:sup>) compared to controls (2,547 [2,153\u20132,932]\u202fmm<jats:sup>2<\/jats:sup>, p&lt;0.001). Following multivariable regression analysis, infants with exomphalos had lower CRTAs compared to controls (p=0.001) after adjusting for differences in gestational age and male sex. In the exomphalos group, the CRTAs were lower in those who developed BPD (n=14, 1,530 [1,307\u20131,941]\u202fmm<jats:sup>2<\/jats:sup>) compared to those who did not (2,168 [1,865\u20132,672], p&lt;0.001). Following multivariable regression analysis, the CRTA was associated with BPD development (p=0.021) after adjusting for male sex and gestational age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2023-0528_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Lower CRTAs on day one in the exomphalos infants compared to the controls predicted BPD development.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2023-0528","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T15:41:50Z","timestamp":1708962110000},"page":"429-432","source":"Crossref","is-referenced-by-count":1,"title":["Prediction of bronchopulmonary dysplasia by the chest radiographic thoracic area on day one in infants with exomphalos"],"prefix":"10.1515","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0515-3961","authenticated-orcid":false,"given":"Mirna","family":"Krishnan","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Centre , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-5301","authenticated-orcid":false,"given":"Theodore","family":"Dassios","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Centre , King\u2019s College Hospital NHS Foundation Trust , London , UK"},{"name":"Department of Women and Children\u2019s Health , School of Life Course Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Bothamley","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Centre , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3782-8261","authenticated-orcid":false,"given":"Saira","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Radiology , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7176-0165","authenticated-orcid":false,"given":"Callum","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Radiology , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0938-2717","authenticated-orcid":false,"given":"Mark","family":"Davenport","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Harris","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Centre , King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-5349","authenticated-orcid":false,"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health , School of Life Course Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"2024050315031392934_j_jpm-2023-0528_ref_001","doi-asserted-by":"crossref","unstructured":"Sakonidou, S, Ali, K, Farmer, I, Hickey, A, Greenough, A. 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