{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:00:24Z","timestamp":1789822824769,"version":"4.0.1"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"8","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2024-0114_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Atenolol is a commonly used beta bloscker in non-pregnant women. Many providers are hesitant in prescribing atenolol in pregnancy because of a possible association with poor fetal growth. We aimed to assess the association between atenolol and the occurrence of small for gestational age neonates compared to other beta blockers, as described in the existing literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0114_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used the meta-analytic method to generate a forest plot for risk ratios (RR) of small for gestational age in patients who used atenolol vs. other beta blockers. Statistical heterogeneity was assessed with the I<jats:sup>2<\/jats:sup> statistic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0114_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two studies were included, with a resultant RR of 1.94 [95\u202f% confidence interval (CI) 1.60; 2.35]. A study by Duan et\u00a0al. in 2018 noted the following rate of small for gestational age for each beta blocker use: 112\/638 atenolol, 590\/3,357 labetalol, 35\/324 metoprolol, and 50\/489 propranolol. A study by Tanaka et\u00a0al. in 2016 noted the following rate of small for gestational age: 8\/22 for propranolol, 2\/12 for metoprolol, 2\/6 for atenolol, 0\/5 for bisoprolol. Heterogeneity (I<jats:sup>2<\/jats:sup>) was 0\u202f%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0114_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results suggested an elevated risk of small for gestational age associated with atenolol use in comparison to other beta blockers, specifically labetalol, propranolol, bisoprolol, and metoprolol.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2024-0114","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T14:48:52Z","timestamp":1723042132000},"page":"858-862","source":"Crossref","is-referenced-by-count":10,"title":["Does atenolol use during pregnancy cause small for gestational age neonates? A meta-analysis"],"prefix":"10.1515","volume":"52","author":[{"given":"Shauna","family":"Bratton","sequence":"first","affiliation":[{"name":"College of Medicine, University of Arizona , Tucson , AZ , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7999-3845","authenticated-orcid":false,"given":"Megan K.","family":"Taylor","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Arizona , Tucson , AZ , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Cortez","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Arizona , Tucson , AZ , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2994-1093","authenticated-orcid":false,"given":"Antonio","family":"Schiattarella","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialized Surgery , Luigi Vanvitelli University of Campania , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Fochesato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Multimedica Ospedale S. Giuseppe , University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Sisti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, College of Medicine\u00a0\u2013 Tucson, University of Arizona , Tucson , AZ , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"2024100708405467420_j_jpm-2024-0114_ref_001","unstructured":"Beta-blockers\u00a0\u2013 one size blocks them all? Updates in pharmacogenetic education. Arlington, VA: American Association of Colleges of Pharmacy (AACP); 2023."},{"key":"2024100708405467420_j_jpm-2024-0114_ref_002","unstructured":"Farzam, K, Jan, A. Beta blockers. StatPearls. Treasure Island (FL): National Library of Medicine. 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