{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:26:23Z","timestamp":1726100783179},"reference-count":50,"publisher":"Walter de Gruyter GmbH","issue":"7","funder":[{"name":"A new algorithm for the prevention of neurological abnormalities and damage in children with intrauterine growth restriction","award":["Ministry of Science grant number108-108-1870-1940"],"award-info":[{"award-number":["Ministry of Science grant number108-108-1870-1940"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2024-0138_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Fetal hypoxia due to placental dysfunction is the\u00a0hallmark of fetal growth restriction (FGR). Preferential perfusion of the brain (brain-sparing effect), as a part of physiological placental cardiovascular compensatory mechanisms to hypoxia, in FGR was reported. Therefore, the correlation between vascular endothelial growth factor A (VEGF-A) protein expression in the FGR placentas and newborns\u2019 early neurological outcome was examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0138_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study included 50 women with FGR complicated pregnancies and 30 uneventful pregnancies. Fetal hemodynamic parameters, neonatal acid\u2013base status after delivery, placental pathohistology and VEGF-A expression were followed. Early neonatal morphological brain evaluation by ultrasound and functional evaluation of neurological status by Amiel\u00a0\u2013 Tison Neurological Assessment at Term (ATNAT) were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0138_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>VEGF-A protein expression level was significantly higher in the FGR placentas than normal term placentas (Fisher\u2013Freeman\u2013Halton\u2019s test, p\u22640.001). No statistically significant correlation between placental VEGF-A expression and different prenatal and postnatal parameters was noticed. Whereas the alteration of an early neurological status assessed by ATNAT was found in 58\u202f% of FGR newborns, morphological brain changes evaluated by UZV was noticed in 48\u202f% of cases. No association between the level of placental VEGF-A expression and the early neurological deficits was found.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0138_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>As far as we know this is the first study of a possible connection between VEGF-A protein expression in the FGR placentas and neonates\u2019 early neurological outcomes. The lack of correlation between the FGR placental VEGF-A expression and neonates\u2019 neurological outcome could indicate that optimal early neurodevelopment may take place due to compensatory mechanism not related to placental VEGF-A expression.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2024-0138","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T16:56:30Z","timestamp":1721408190000},"page":"783-792","source":"Crossref","is-referenced-by-count":0,"title":["Does placental VEGF-A protein expression predict early neurological outcome of neonates from FGR complicated pregnancies?"],"prefix":"10.1515","volume":"52","author":[{"given":"Maja","family":"Grah","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Hospital \u201cSveti Duh\u201d, School of Medicine , 37632 University of Zagreb , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana","family":"Poljak","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine , 37632 University of Zagreb , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirta","family":"Star\u010devi\u0107","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Gynecology and Obstetrics , Clinical Hospital Center \u201cZagreb\u201d , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Stanojevi\u0107","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Department of Obstetrics and Gynecology, Clinical Hospital \u201cSveti Duh\u201d, School of Medicine , 37632 University of Zagreb , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Vukojevi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Early Human Development, Department of Anatomy, Histology and Embryology , University of Split School of Medicine , Split , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirna","family":"Saraga-Babi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Early Human Development, Department of Anatomy, Histology and Embryology , University of Split School of Medicine , Split , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida Kadi\u0107","family":"Salihagi\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine , 37632 University of Zagreb , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"2024091113160745278_j_jpm-2024-0138_ref_001","doi-asserted-by":"crossref","unstructured":"Huppertz, B, Peeters, LLH. 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