{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:16:43Z","timestamp":1794003403993,"version":"4.8.0"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"5","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2024-0321_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the antidiuretic effects of oxytocin and carbetocin in patients undergoing elective caesarean section.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2024-0321_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 276 participants who underwent elective singleton caesarean sections, with 184 receiving oxytocin and 92 receiving carbetocin. Exclusion criteria comprised patients with additional medical conditions or drug use affecting urine output, those diagnosed with postpartum hemorrhage, and those requiring non-standard intravenous fluid administration or additional uterotonics. Data on demographic characteristics, urinary output, time to reach specific urine output thresholds (500\u202fmL, 1,000\u202fmL, and 1,500\u202fmL), vital signs, and hemoglobin levels were collected and compared between the oxytocin and carbetocin groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2024-0321_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no significant differences in demographic characteristics between the groups. There were no significant differences in preoperative and postoperative hemoglobin levels, vital signs or duration of hospitalization between the two groups. The carbetocin group exhibited significantly higher total urine output in the first 6\u202fh compared to the oxytocin group (p=0.037). The time required to achieve urine output volumes of 500, 1,000, and 1,500\u202fmL did not differ significantly between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2024-0321_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Carbetocin may exert a less pronounced antidiuretic effect than oxytocin following elective caesarean section in a cohort with as few confounding factors as possible. Further prospective studies are warranted to validate these findings and assess their clinical implications in postpartum hemorrhage prophylaxis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2024-0321","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T06:00:16Z","timestamp":1744783216000},"page":"576-581","source":"Crossref","is-referenced-by-count":2,"title":["Comparative analysis of antidiuretic effects of oxytocin and carbetocin in postpartum hemorrhage prophylaxis: a retrospective cohort study"],"prefix":"10.1515","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-0462","authenticated-orcid":false,"given":"Umutcan","family":"Kay\u0131k\u00e7\u0131","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal and Fetal Medicine , 64005 Hacettepe University Faculty of Medicine , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7953-2517","authenticated-orcid":false,"given":"Erdem","family":"Fad\u0131lo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal and Fetal Medicine , 64005 Hacettepe University Faculty of Medicine , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-3663","authenticated-orcid":false,"given":"Ay\u015fe \u00c7i\u011fdem","family":"Bayrak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal and Fetal Medicine , 64005 Hacettepe University Faculty of Medicine , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-3624","authenticated-orcid":false,"given":"Edip Alptu\u011f","family":"K\u0131r","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal and Fetal Medicine , 64005 Hacettepe University Faculty of Medicine , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-4229","authenticated-orcid":false,"given":"\u0130rem","family":"Herg\u00fcner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , Hacettepe University Faculty of Medicine , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7307-7153","authenticated-orcid":false,"given":"Kheyransa","family":"\u0130skandarli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , Hacettepe University Faculty of Medicine , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-2444","authenticated-orcid":false,"given":"\u00d6zg\u00fcr","family":"Deren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal and Fetal Medicine , 64005 Hacettepe University Faculty of Medicine , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"2025060211104097642_j_jpm-2024-0321_ref_001","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists\u2019 Committee on Practice Bulletins\u2013Obstetrics. Practice bulletin No. 183: postpartum hemorrhage. Obstet Gynecol 2017;130:168\u201386. https:\/\/doi.org\/10.1097\/AOG.0000000000002351.","DOI":"10.1097\/AOG.0000000000002351"},{"key":"2025060211104097642_j_jpm-2024-0321_ref_002","unstructured":"WHO. WHO recommendations for the prevention and treatment of postpartum haemorrhage. Geneva: World Health Organization; 2012. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK131942\/."},{"key":"2025060211104097642_j_jpm-2024-0321_ref_003","doi-asserted-by":"crossref","unstructured":"Widmer, M, Piaggio, G, Nguyen, TMH, Osoti, A, Owa, OO, Misra, S, et al.. Heat-stable carbetocin versus oxytocin to prevent hemorrhage after vaginal birth. N Engl J Med 2018;379:743\u201352. https:\/\/doi.org\/10.1056\/nejmoa1805489.","DOI":"10.1056\/NEJMoa1805489"},{"key":"2025060211104097642_j_jpm-2024-0321_ref_004","unstructured":"WHO expert committee on the selection and use of essential Medicines. Web annex A. 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Mymensingh Med J 2022;31:72\u20139."}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpm-2024-0321\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpm-2024-0321\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T07:10:54Z","timestamp":1748848254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpm-2024-0321\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,4,8]]},"published-print":{"date-parts":[[2025,6,26]]}},"alternative-id":["10.1515\/jpm-2024-0321"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2024-0321","relation":{},"ISSN":["0300-5577","1619-3997"],"issn-type":[{"value":"0300-5577","type":"print"},{"value":"1619-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]}}}