{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:19:06Z","timestamp":1793369946516,"version":"4.5.0"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2024-0440_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To analyze pregnancy outcomes and factors influencing early-onset intrahepatic cholestasis of pregnancy (ICP), offering insights to improve the management, diagnosis, and treatment of ICP during pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0440_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We categorized 127 pregnant women with ICP into two groups based on a gestational age cutoff of 28\u00a0weeks. The analysis centered on biochemical markers, pregnancy complications, and outcomes to identify factors influencing early-onset ICP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0440_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that biochemical markers including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase (GGT), alkaline phosphatase, total bilirubin, direct bilirubin (DBIL), indirect bilirubin, and cholesterol were significantly lower in early-onset ICP compared to late-onset ICP. Importantly, premature birth rates were higher in the early-onset ICP group. Through univariate and multivariate logistic regression analyses of these biochemical markers, GGT and DBIL emerged as significant predictive factors (OR=0.84 and 0.54).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0440_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Early-onset ICP is characterized by its early onset, prolonged duration, and a higher incidence of premature births compared to late-onset ICP, leading to adverse perinatal outcomes. This research underscores the\u00a0protective role of GGT and DBIL in early-onset ICP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2024-0440","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T12:20:38Z","timestamp":1735215638000},"page":"332-337","source":"Crossref","is-referenced-by-count":3,"title":["Determinants of pregnancy outcomes in early-onset intrahepatic cholestasis of pregnancy"],"prefix":"10.1515","volume":"53","author":[{"given":"Xiufang","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics , Fujian Provincial Maternity and Children\u2019s Hospital , Fuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Fujian Provincial Maternity and Children\u2019s Hospital , Fuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingling","family":"Xiu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Fujian Provincial Maternity and Children\u2019s Hospital , Fuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunhai","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Fujian Provincial Maternity and Children\u2019s Hospital , Fuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Fujian Provincial Maternity and Children\u2019s Hospital , Fuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"2025041510091090982_j_jpm-2024-0440_ref_001","doi-asserted-by":"crossref","unstructured":"Williamson, C, Geenes, V. 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