{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T20:48:34Z","timestamp":1777063714571,"version":"3.51.4"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"5","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2024-0528_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study evaluates the perinatal and neonatal outcomes of pregnant women with severe thrombocytopenia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0528_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cross-sectional analysis was conducted on pregnant women with platelet counts below 50\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L in a tertiary university hospital between January 2015 and May 2024. Patients were divided into two groups according to their lowest platelet counts. Maternal and neonatal outcomes were systematically recorded and analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0528_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 195 pregnant women were included in the study, 72 of whom were in Group A (0\u201330\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L) and 123 in Group B (30\u201350\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L). In our study, immune thrombocytopenic purpura was the most common cause of severe thrombocytopenia, accounting for 56.6\u202f% of cases. Significant differences were observed in the rates of preterm birth (&lt;34\u00a0weeks) and neonatal intensive care unit (NICU) admission, with higher rates in Group A (p=0.035 and p=0.05, respectively). No significant differences were found in other maternal and neonatal outcomes, including postpartum hemorrhage rates, between the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2024-0528_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In pregnancies complicated by severe thrombocytopenia with a platelet count &lt;30\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L, there is an increased risk of preterm birth before 34\u00a0weeks and NICU admission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2024-0528","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T20:39:46Z","timestamp":1744490386000},"page":"582-587","source":"Crossref","is-referenced-by-count":2,"title":["Severe thrombocytopenia in pregnancy: a\u00a0cross-sectional analysis of perinatal and neonatal outcomes across different platelet count categories"],"prefix":"10.1515","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-5799","authenticated-orcid":false,"given":"Huriye","family":"Ezveci","sequence":"first","affiliation":[{"name":"Division of Maternal and Fetal Medicine , Necmettin Erbakan University (NEU) Faculty of Medicine , Konya , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e\u00fckran","family":"Do\u011fru","sequence":"additional","affiliation":[{"name":"Konya City Hospital , Konya , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikriye","family":"Karanfil Yaman","sequence":"additional","affiliation":[{"name":"Division of Maternal and Fetal Medicine , Necmettin Erbakan University (NEU) Faculty of Medicine , Konya , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahre","family":"Bergama","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University (NEU) Faculty of Medicine, Gynecology, and Obstetrics , Konya , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"2025060211104109411_j_jpm-2024-0528_ref_001","doi-asserted-by":"crossref","unstructured":"Fogerty, AE. Thrombocytopenia in pregnancy: mechanisms and management. Transfus Med Rev 2018;32:225\u20139. https:\/\/doi.org\/10.1016\/j.tmrv.2018.08.004.","DOI":"10.1016\/j.tmrv.2018.08.004"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_002","doi-asserted-by":"crossref","unstructured":"Reese, JA, Peck, JD, Deschamps, DR, McIntosh, JJ, Knudtson, EJ, Terrell, DR, et al.. Platelet counts during pregnancy. N\u00a0Engl J Med 2018;379:32\u201343. https:\/\/doi.org\/10.1056\/nejmoa1802897.","DOI":"10.1056\/NEJMoa1802897"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_003","doi-asserted-by":"crossref","unstructured":"Turrentine, M. ACOG practice bulletin no. 207: thrombocytopenia in pregnancy. Obstet Gynecol 2019;133:e181\u201393. https:\/\/doi.org\/10.1097\/AOG.0000000000003100.","DOI":"10.1097\/AOG.0000000000003100"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_004","doi-asserted-by":"crossref","unstructured":"Williamson, DR, Albert, M, Heels-Ansdell, D, Arnold, DM, Lauzier, F, Zarychanski, R, et al.. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest 2013;144:1207\u201315. https:\/\/doi.org\/10.1378\/chest.13-0121.","DOI":"10.1378\/chest.13-0121"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_005","doi-asserted-by":"crossref","unstructured":"Reese, JA, Peck, JD, Deschamps, DR, McIntosh, JJ, Knudtson, EJ, Terrell, DR, et al.. Platelet counts during pregnancy. N\u00a0Engl J Med 2018;379:32\u201343. https:\/\/doi.org\/10.1056\/nejmoa1802897.","DOI":"10.1056\/NEJMoa1802897"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_006","doi-asserted-by":"crossref","unstructured":"Gernsheimer, T, James, AH, Stasi, R. How I treat thrombocytopenia in pregnancy. Blood 2013;121:38\u201347. https:\/\/doi.org\/10.1182\/blood-2012-08-448944.","DOI":"10.1182\/blood-2012-08-448944"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_007","doi-asserted-by":"crossref","unstructured":"Myers, B. Diagnosis and management of maternal thrombocytopenia in pregnancy. Br J Haematol 2012;158:3\u201315. https:\/\/doi.org\/10.1111\/j.1365-2141.2012.09135.x.","DOI":"10.1111\/j.1365-2141.2012.09135.x"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_008","doi-asserted-by":"crossref","unstructured":"Turrentine, M, American College of Obstetricians and Gynecologists\u2019 Committee on Practice Bulletins \u2013\u00a0Obstetrics. 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Pregnancies with platelet count lower than 70000 platelets\/\u03bcl. Gynaecol Obstet Reprod Med 2006;12:92\u20135."},{"key":"2025060211104109411_j_jpm-2024-0528_ref_015","unstructured":"\u00d6zdemir, S, G\u00f6rkemli, H, Acar, A, \u00c7elik, \u00c7, Kay\u0131k\u00e7\u0131o\u011flu, E. A comparison of maternal and fetal outcomes of pregnancies complicated by moderate to severe thrombocytopenia caused by gestational thrombocytopenia preeclampsia\/HELLP syndrome and immune thrombocytopenic purpura. Gynaecol Obstet Reprod Med 2008;14:154\u20138."},{"key":"2025060211104109411_j_jpm-2024-0528_ref_016","unstructured":"Be\u015fe, E, B\u0131ld\u0131rc\u0131n, FD, Malatyal\u0131o\u011flu, E. The effects of preeclampsia severity and thrombocytopenia on the prognosis of hypertensive pregnant women. Gynaecol Obstet Reprod Med 2013;19:12\u201318."},{"key":"2025060211104109411_j_jpm-2024-0528_ref_017","unstructured":"Dwivedi, P, Puri, M, Nigam, A, Agarwal, K. 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J\u00a0Perinat Med 2024;52:831\u20136. https:\/\/doi.org\/10.1515\/jpm-2024-0120.","DOI":"10.1515\/jpm-2024-0120"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_020","doi-asserted-by":"crossref","unstructured":"Neunert, C, Terrell, DR, Arnold, DM, Buchanan, G, Cines, DB, Cooper, N, et al.. American society of hematology 2019 guidelines for immune thrombocytopenia. Blood Adv 2019;3:3829\u201366. https:\/\/doi.org\/10.1182\/bloodadvances.2019000966.","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_021","doi-asserted-by":"crossref","unstructured":"Cines, DB, Bussel, JB. How I treat idiopathic thrombocytopenic purpura (ITP). Blood 2005;106:2244\u201351. https:\/\/doi.org\/10.1182\/blood-2004-12-4598.","DOI":"10.1182\/blood-2004-12-4598"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_022","doi-asserted-by":"crossref","unstructured":"George, JN, Nester, CM. Syndromes of thrombotic microangiopathy. 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J\u00a0Matern Fetal Neonatal Med 2005;18:149\u201354. https:\/\/doi.org\/10.1080\/14767050500170088.","DOI":"10.1080\/14767050500170088"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_028","doi-asserted-by":"crossref","unstructured":"Estcourt, LJ, Malouf, R, Hopewell, S, Doree, C, Van Veen, J. Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia. Cochrane Database Syst Rev 2018;4:Cd011980. https:\/\/doi.org\/10.1002\/14651858.CD011980.pub3.","DOI":"10.1002\/14651858.CD011980.pub3"},{"key":"2025060211104109411_j_jpm-2024-0528_ref_029","doi-asserted-by":"crossref","unstructured":"Bauer, ME, Arendt, K, Beilin, Y, Gernsheimer, T, Perez Botero, J, James, AH, et al.. The society for obstetric anesthesia and perinatology interdisciplinary consensus statement on neuraxial procedures in obstetric patients with thrombocytopenia. 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