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Fetal facial expressions, shaped by Cranial Nerve VII, reflect evolutionary adaptations for nonverbal communication and exhibit minimal asymmetry in universal expressions. Advancements in 4D ultrasound imaging and artificial intelligence (AI) have introduced innovative methods for analyzing these movements, revealing their potential as diagnostic tools for neurodevelopmental disorders like Bell\u2019s Palsy and Ramsay Hunt Syndrome before birth. These technologies promise early interventions that could significantly improve neonatal outcomes. By integrating imaging, AI, and longitudinal studies, researchers propose a multidisciplinary approach to establish diagnostic criteria for fetal facial movements. However, translating these advancements into clinical practice requires addressing ethical and practical challenges, refining imaging and AI methodologies, and fostering interdisciplinary collaboration. The review highlights the universality of fetal expressions while emphasizing the importance of distinguishing typical variability from pathological markers. In conclusion, these findings suggest transformative potential for maternal-fetal medicine, paving the way for proactive strategies to manage neurodevelopmental risks. Focused research is essential to fully harness these innovations and establish a new frontier in perinatal science.<\/jats:p>","DOI":"10.1515\/jpm-2024-0602","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T17:59:50Z","timestamp":1739469590000},"page":"263-285","source":"Crossref","is-referenced-by-count":18,"title":["AI and early diagnostics: mapping fetal facial expressions through development, evolution, and 4D ultrasound"],"prefix":"10.1515","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9062-8501","authenticated-orcid":false,"given":"Wiku","family":"Andonotopo","sequence":"first","affiliation":[{"name":"Fetomaternal Division, Women Health Center, Department of Obstetrics and Gynecology , Eka Hospital BSD City , Serpong , Tangerang , Banten , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-3909","authenticated-orcid":false,"given":"Muhammad Adrianes","family":"Bachnas","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Sebelas Maret University, Dr. Moewardi Hospital , Solo , Surakarta , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Dewantiningrum","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mochammad Besari","family":"Adi Pramono","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Stanojevic","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Rare Diseases , Medical University of Warsaw , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Kurjak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Medical School University of Zagreb , Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"2025041510091101951_j_jpm-2024-0602_ref_001","doi-asserted-by":"crossref","unstructured":"Bachnas, MA, Andonotopo, W, Dewantiningrum, J, Pramono, MBA, Stanojevic, M, Kurjak, A. 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