{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:04:54Z","timestamp":1793153094702,"version":"4.5.0"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"7","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The advent of non-invasive prenatal testing (NIPT) utilizing cell-free fetal DNA (cfDNA) has transformed the landscape of early chromosomal anomaly detection. When paired with high-resolution ultrasound imaging, it establishes a robust framework for prenatal diagnostics. This study explores the efficacy of merging NIPT findings with detailed ultrasound markers to enhance the identification of both chromosomal and structural fetal abnormalities. Data from 190 cases demonstrated a cfDNA efficacy rate of 91.58\u202f% (cfDNA \u22654\u202f%) and a detection rate of 4.74\u202f% for aneuploidies. The investigation delves into key findings for trisomies, monosomies, and physical malformations, backed by state-of-the-art diagnostic benchmarks. Markers such as\u00a0nuchal translucency (NT), craniofacial characteristics, and cardiac irregularities were analyzed alongside genetic results. This integrative strategy significantly refines diagnostic precision, paving the way for personalized prenatal care and management.<\/jats:p>","DOI":"10.1515\/jpm-2025-0005","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T02:55:10Z","timestamp":1748400910000},"page":"789-802","source":"Crossref","is-referenced-by-count":19,"title":["Integrating NIPT and ultrasound for detecting fetal aneuploidies and abnormalities"],"prefix":"10.1515","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9062-8501","authenticated-orcid":false,"given":"Wiku","family":"Andonotopo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division , Eka Hospital BSD City , Serpong, Tangerang , Banten , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-3909","authenticated-orcid":false,"given":"Muhammad Adrianes","family":"Bachnas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division , Faculty of Medicine Sebelas Maret University, Dr. Moewardi General Hospital , Solo , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-2264","authenticated-orcid":false,"given":"Adhi","family":"Pribadi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division , Faculty of Medicine Padjadjaran University, Hasan Sadikin General Hospital , Bandung , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1785-6214","authenticated-orcid":false,"given":"Muhammad","family":"Alamsyah Azis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division , Faculty of Medicine Padjadjaran University, Hasan Sadikin General Hospital , Bandung , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2003-9282","authenticated-orcid":false,"given":"Muhammad Ilham","family":"Aldika Akbar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division , Faculty of Medicine Airlangga University, Dr. Soetomo General Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ernawati","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division , Faculty of Medicine Airlangga University, Dr. Soetomo General Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Nyoman","family":"Hariyasa Sanjaya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Universitas Udayana, I.G.N.G Ngoerah Central Hospital , Bali , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anak Agung Gede","family":"Putra Wiradnyana","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Universitas Udayana, I.G.N.G Ngoerah Central Hospital , Bali , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudy","family":"Aldiansyah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Maternal-Fetal Medicine Division , Universitas Sumatera Utara, H. Adam Malik General Hospital , Medan , Sumatera Utara , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Dewantiningrum","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mochammad Besari","family":"Adi Pramono","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wantania","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Maternal-Fetal Medicine Division, Medical Faculty , Sam Ratulangi University, R.D. Kandou General Hospital , Manado , North Sula , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri","family":"Sulistyowati","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division , Faculty of Medicine Sebelas Maret University, Sebelas Maret University Hospital , Solo , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Stanojevic","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Rare Diseases , Medical University of Warsaw , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Kurjak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Medical School\u00a0University of Zagreb , Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"2026051215142316368_j_jpm-2025-0005_ref_001","doi-asserted-by":"crossref","unstructured":"Audibert, F, Wou, K, Okun, N, De Bie, I, Wilson, RD. 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