{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:26:56Z","timestamp":1773178016284,"version":"3.50.1"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"5","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Fundamental Scientific Research Project of Wenzhou","award":["Y2023018"],"award-info":[{"award-number":["Y2023018"]}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LBY23H200008"],"award-info":[{"award-number":["LBY23H200008"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ21H040007)"],"award-info":[{"award-number":["LQ21H040007)"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Health Science and Technology Project of Zhejiang Provincial","award":["2024KY1627"],"award-info":[{"award-number":["2024KY1627"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2025-0025_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Pre-eclampsia and fetal growth restriction (FGR) is a serious complication of pregnancy. Our study aimed to identify the DEGs and pathways in the placentas of patients with pre-eclampsia and FGR and investigated the relationships between these genes and clinical characteristics to elucidate the dysregulated placental mechanisms linked to pre-eclampsia and\u00a0FGR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2025-0025_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 28 patients were enrolled in the study (6 individuals were selected for RNA sequencing and 22 participants was subjected to qRT-PCR). We used RNA sequencing to identify DEGs and pathways in the placenta. Ten DEGs were verified using qRT-PCR. The relationships between these DEGs and clinical characteristics were investigated using correlation analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2025-0025_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We detected significant molecular changes in the placentas of pre-eclampsia and FGR, encompassing diverse biological processes. <jats:italic>SYDE1<\/jats:italic>, <jats:italic>HTRA1<\/jats:italic>, and <jats:italic>PAPPA2<\/jats:italic> expression was significantly upregulated, whereas <jats:italic>MYL9<\/jats:italic>, <jats:italic>OLFML3<\/jats:italic>, <jats:italic>VTN<\/jats:italic>, and <jats:italic>AXNA8<\/jats:italic> expression was downregulated (p&lt;0.05). The mRNA expression levels of <jats:italic>SYDE1<\/jats:italic>, <jats:italic>HTRA1<\/jats:italic> and <jats:italic>PAPPA2<\/jats:italic> displayed a positive correlation with systolic and diastolic blood pressure, LDH and LST, while exhibiting a negative correlation with fetal weight and serum albumin. And the mRNA expression levels of <jats:italic>MYL9<\/jats:italic>, <jats:italic>OLFML3<\/jats:italic>, <jats:italic>VTN<\/jats:italic>, and <jats:italic>ANXA8<\/jats:italic> were significantly negatively correlated with systolic and diastolic blood pressure, LDH and LST, while exhibiting a positive correlation with fetal weight.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2025-0025_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study found variations in gene expression and pathways in the placenta that may contribute to pre-eclampsia and FGR. Genes expressed in the placenta that are associated with clinical indicators could serve as potential biomarkers for assessing the occurrence of pre-eclampsia and\u00a0FGR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2025-0025","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T08:57:34Z","timestamp":1745657854000},"page":"595-603","source":"Crossref","is-referenced-by-count":2,"title":["Differentially expressed genes in the placentas with pre-eclampsia and fetal growth restriction using RNA sequencing and verification"],"prefix":"10.1515","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3053-3276","authenticated-orcid":false,"given":"Haiying","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqiong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"2025060211104108654_j_jpm-2025-0025_ref_001","doi-asserted-by":"crossref","unstructured":"Colson, A, Sonveaux, P, Debi\u00e8ve, F, Sferruzzi-Perri, AN. 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