{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T09:29:25Z","timestamp":1766222965704,"version":"3.48.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0078_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study compared adverse perinatal outcomes between pregnancies complicated by periviable fetal growth restriction (pFGR) that underwent weekly sonographic surveillance vs. serial growth surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0078_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, pFGR was defined as a 22\u00a00\/7\u201327 6\/7-week singleton, &lt;500\u202fg, and\u00a0\u226410\u202f% for gestational age. The surveillance group initiated weekly Doppler surveillance while the serial growth (SG) group underwent growth assessment every 3\u20134\u00a0weeks between 22 and 27\u00a06\/7\u00a0weeks. Adverse perinatal outcomes were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0078_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty-one (36.2\u202f%) underwent weekly Doppler surveillance. Chronic hypertension (18.5\u202f% vs. 9.1\u202f%, p=0.04), a prior history of fetal demise (8.6\u202f% vs. 2.1\u202f%, p=0.02), and an estimated fetal weight &lt;3\u202f% (22.2\u202f% vs. 10.5\u202f%, p=0.02) and any abnormal umbilical artery Doppler pattern at diagnosis (25.8\u202f% vs. 12.9\u202f%, p=0.046) occurred more frequently in the weekly Doppler surveillance group than the SG group. Despite no difference in perinatal death, the surveillance group demonstrated a higher rate of obstetric (65.4\u202f% vs. 42.7\u202f%, p&lt;0.05) and neonatal (60.8\u202f% vs. 28.4\u202f%, p&lt;0.05) adverse outcome composites compared to the SG\u00a0group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0078_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The surveillance group experienced increased rates of obstetric and neonatal morbidity without difference in perinatal death though interpretation is limited by the observational nature of this\u00a0study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0078","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T18:58:07Z","timestamp":1755802687000},"source":"Crossref","is-referenced-by-count":0,"title":["Sonographic surveillance and perinatal outcomes among pregnancies with periviable fetal growth restriction"],"prefix":"10.1515","author":[{"given":"Felicia V.","family":"LeMoine","sequence":"first","affiliation":[{"name":"Department of Reproductive Biology , 2559 Case Western Reserve University , Cleveland , OH , USA"},{"name":"Department of Obstetrics and Gynecology , The MetroHealth System , Cleveland , OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela C.","family":"Ranzini","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology , 2559 Case Western Reserve University , Cleveland , OH , USA"},{"name":"Department of Obstetrics and Gynecology , The MetroHealth System , Cleveland , OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa R.","family":"Imbroane","sequence":"additional","affiliation":[{"name":"School of Medicine , Case Western Reserve University , Cleveland , OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esha V.","family":"Ghosalkar","sequence":"additional","affiliation":[{"name":"School of Medicine , Case Western Reserve University , Cleveland , OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Hackney","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology , 2559 Case Western Reserve University , Cleveland , OH , USA"},{"name":"Department of Obstetrics and Gynecology , University Hospitals Cleveland Medical Center , Cleveland , OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily J.","family":"Hamburg-Shields","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology , 2559 Case Western Reserve University , Cleveland , OH , USA"},{"name":"Department of Obstetrics and Gynecology , University Hospitals Cleveland Medical Center , Cleveland , OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"2025122009100293478_j_jpm-2025-0078_ref_001","doi-asserted-by":"crossref","unstructured":"Fetal Growth Restriction. ACOG Practice Bulletin, Number 227. Obstet Gynecol 2021;137:e16\u201328. https:\/\/doi.org\/10.1097\/AOG.0000000000004251.","DOI":"10.1097\/AOG.0000000000004251"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_002","doi-asserted-by":"crossref","unstructured":"Gordijn, SJ, Beune, IM, Thilaganathan, B, Papageorghiou, A, Baschat, AA, Baker, PN, et al.. Consensus definition of fetal growth restriction: a Delphi procedure. Ultrasound Obstet Gynecol 2016;48:333\u20139. https:\/\/doi.org\/10.1002\/uog.15884.","DOI":"10.1002\/uog.15884"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_003","doi-asserted-by":"crossref","unstructured":"Vasak, B, Koenen, SV, Koster, MP, Hukkelhoven, CW, Franx, A, Hanson, MA, et al.. Human fetal growth is constrained below optimal for perinatal survival. Ultrasound Obstet Gynecol 2015;45:162\u20137. https:\/\/doi.org\/10.1002\/uog.14644.","DOI":"10.1002\/uog.14644"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_004","doi-asserted-by":"crossref","unstructured":"Francis, JH, Permezel, M, Davey, MA. Perinatal mortality by birthweight centile. Aust N Z J Obstet Gynaecol 2014;54:354\u20139. https:\/\/doi.org\/10.1111\/ajo.12205.","DOI":"10.1111\/ajo.12205"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_005","doi-asserted-by":"crossref","unstructured":"Glinianaia, SV, Rankin, J, Pearce, MS, Parker, L, Pless-Mulloli, T. Stillbirth and infant mortality in singletons by cause of death, birthweight, gestational age and birthweight-for-gestation, Newcastle upon Tyne 1961\u20132000. Paediatr Perinat Epidemiol 2010;24:331\u201342. https:\/\/doi.org\/10.1111\/j.1365-3016.2010.01119.x.","DOI":"10.1111\/j.1365-3016.2010.01119.x"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_006","doi-asserted-by":"crossref","unstructured":"Vangen, S, Stoltenberg, C, Skjaerven, R, Magnus, P, Harris, JR, Stray-Pedersen, B. The heavier the better? Birthweight and perinatal mortality in different ethnic groups. Int J Epidemiol 2002;31:654\u201360. https:\/\/doi.org\/10.1093\/ije\/31.3.654.","DOI":"10.1093\/ije\/31.3.654"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_007","doi-asserted-by":"crossref","unstructured":"Zhang-Rutledge, K, Mack, LM, Mastrobattista, JM, Gandhi, M. Significance and outcomes of fetal growth restriction below the 5th percentile compared to the 5th to 10th percentiles on midgestation growth ultrasonography. J\u00a0Ultrasound Med 2018;37:2243\u20139. https:\/\/doi.org\/10.1002\/jum.14577.","DOI":"10.1002\/jum.14577"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_008","doi-asserted-by":"crossref","unstructured":"Sibai, B, Dekker, G, Kupferminc, M. Pre-eclampsia. Lancet 2005;365:785\u201399. https:\/\/doi.org\/10.1016\/S0140-6736-05-17987-2.","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_009","doi-asserted-by":"crossref","unstructured":"Downes, KL, Grantz, KL, Shenassa, ED. Maternal, labor, delivery, and perinatal outcomes associated with placental abruption: a systematic review. Am J Perinatol 2017;34:935\u201357. https:\/\/doi.org\/10.1055\/s-0037-1599149.","DOI":"10.1055\/s-0037-1599149"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_010","doi-asserted-by":"crossref","unstructured":"Rodriguez-Sibaja, MJ, Mendez-Pi\u00f1a, MA, Lumbreras-Marquez, MI, Acevedo-Gallegos, S, Velazquez-Torres, B, Ramirez-Calvo, JA. Intended delivery mode and neonatal outcomes in pregnancies with fetal growth restriction. J\u00a0Matern Fetal Neonatal Med 2023;36:2286433. https:\/\/doi.org\/10.1080\/14767058.2023.2286433.","DOI":"10.1080\/14767058.2023.2286433"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_011","doi-asserted-by":"crossref","unstructured":"Gardosi, JO. Prematurity and fetal growth restriction. Early Hum Dev 2005;81:43\u20139. https:\/\/doi.org\/10.1016\/j.earlhumdev.2004.10.015.","DOI":"10.1016\/j.earlhumdev.2004.10.015"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_012","doi-asserted-by":"crossref","unstructured":"Stewart, B, Karahalios, A, Pszczola, R, Said, J. Moderate to late preterm intrauterine growth restriction: a restrospective, observational study of the indications for delivery and outcomes in an Australian perinatal centre. Aust N Z J Obstet Gynaecol 2018;58:306\u201314. https:\/\/doi.org\/10.1111\/ajo.12721.","DOI":"10.1111\/ajo.12721"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_013","doi-asserted-by":"crossref","unstructured":"Kleuskens, DG, Van Veen, CMC, Groenendaal, F, Ganzevoort, W, Gordijn, SJ, Van Rijn, BB, et al.. Prediction of fetal and neonatal outcomes after preterm manifestations of placental insufficiency: systematic review of prediction models. Ultrasound Obstet Gynecol 2023;62:644\u201352. https:\/\/doi.org\/10.1002\/uog.26245.","DOI":"10.1002\/uog.26245"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_014","doi-asserted-by":"crossref","unstructured":"Rebelo, F, Carrilho, TRB, Canuto, R, Schlussel, MM, Farias, DR, Ohuma, EO, et al.. Estimated fetal weight standards of the INTERGROWTH-21st project for the prediction of adverse outcomes: a systematic review with meta-analysis. J\u00a0Matern Fetal Neonatal Med 2023;36:2230510. https:\/\/doi.org\/10.1080\/14767058.2023.2230510.","DOI":"10.1080\/14767058.2023.2230510"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_015","doi-asserted-by":"crossref","unstructured":"Kramer, MS, Olivier, M, McLean, FH, Willis, DM, Usher, RH. Impact of intrauterine growth retardation and body proportionality on fetal and neonatal outcome. Pediatrics 1990;86:707\u201313. https:\/\/doi.org\/10.1542\/peds.86.5.707.","DOI":"10.1542\/peds.86.5.707"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_016","doi-asserted-by":"crossref","unstructured":"Gilbert, WM, Danielsen, B. Pregnancy outcomes associated with intrauterine growth restriction. Am J Obstet Gynecol 2003;188:1596\u20139; discussion 1599-601. https:\/\/doi.org\/10.1067\/mob.2003.384.","DOI":"10.1067\/mob.2003.384"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_017","doi-asserted-by":"crossref","unstructured":"Longo, S, Bollani, L, Decembrino, L, Di Comite, A, Angelini, M, Stronati, M. Short-term and long-term sequelae in intrauterine growth retardation (IUGR). J\u00a0Matern Fetal Neonatal Med 2013;26:222\u20135. https:\/\/doi.org\/10.3109\/14767058.2012.715006.","DOI":"10.3109\/14767058.2012.715006"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_018","doi-asserted-by":"crossref","unstructured":"Rosenberg, A. The IUGR newborn. Semin Perinatol 2008;32:219\u201324. https:\/\/doi.org\/10.1053\/j.semperi.2007.11.003.","DOI":"10.1053\/j.semperi.2007.11.003"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_019","doi-asserted-by":"crossref","unstructured":"Mendoza, M, Hurtado, I, Bonacina, E, Garcia-Manau, P, Serrano, B, Tur, H, et al.. Individual risk assessment for prenatal counseling in early-onset growth-restricted and small-for-gestational-age fetuses. Acta Obstet Gynecol Scand 2021;100:504\u201312. https:\/\/doi.org\/10.1111\/aogs.14032.","DOI":"10.1111\/aogs.14032"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_020","doi-asserted-by":"crossref","unstructured":"Meler, E, Mazarico, E, Peguero, A, Gonzalez, A, Martinez, J, Boada, D, et al.. Death and severe morbidity in isolated periviable small-for-gestational-age fetuses. BJOG 2023;130:485\u201393. https:\/\/doi.org\/10.1111\/1471-0528.17181.","DOI":"10.1111\/1471-0528.17181"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_021","doi-asserted-by":"crossref","unstructured":"Lawin-O\u2019Brien, AR, Dall\u2019Asta, A, Knight, C, Sankaran, S, Scala, C, Khalil, A, et al.. Short-term outcome of periviable small-for-gestational-age babies: is our counseling up to date? Ultrasound Obstet Gynecol 2016;48:636\u201341. https:\/\/doi.org\/10.1002\/uog.15973.","DOI":"10.1002\/uog.15973"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_022","doi-asserted-by":"crossref","unstructured":"Li, N, Ghosh, G, Gudmundsson, S. Uterine artery Doppler in high-risk pregnancies at 23-24 gestational weeks is of value in predicting adverse outcome of pregnancy and selecting cases for more intense surveillance. Acta Obstet Gynecol Scand 2014;93:1276\u201381. https:\/\/doi.org\/10.1111\/aogs.12488.","DOI":"10.1111\/aogs.12488"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_023","doi-asserted-by":"crossref","unstructured":"Lingam, I, Okell, J, Maksym, K, Spencer, R, Peebles, D, Buquis, G, et al.. Neonatal outcomes following early fetal growth restriction: a subgroup analysis of the EVERREST study. Arch Dis Child Fetal Neonatal Ed 2023;108:599\u2013606. https:\/\/doi.org\/10.1136\/archdischild-2022-325285.","DOI":"10.1136\/archdischild-2022-325285"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_024","doi-asserted-by":"crossref","unstructured":"Gupta, S, Naert, M, Lam-Rachlin, J, Monteagudo, A, Rebarber, A, Saltzman, D, et al.. Outcomes in patients with early-onset fetal growth restriction without fetal or genetic anomalies. J\u00a0Matern Fetal Neonatal Med 2019;32:2662\u20136. https:\/\/doi.org\/10.1080\/14767058.2018.1445711.","DOI":"10.1080\/14767058.2018.1445711"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_025","doi-asserted-by":"crossref","unstructured":"Gairabekova, D, van Rosmalen, J, Duvekot, JJ. Outcome of early-onset fetal growth restriction with or without abnormal umbilical artery Doppler flow. Acta Obstet Gynecol Scand 2021;100:1430\u20138. https:\/\/doi.org\/10.1111\/aogs.14142.","DOI":"10.1111\/aogs.14142"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_026","doi-asserted-by":"crossref","unstructured":"Pels, A, Beune, IM, van Wassenaer-Leemhuis, AG, Limpens, J, Ganzevoort, W. Early-onset fetal growth restriction: a systematic review on mortality and morbidity. Acta Obstet Gynecol Scand 2020;99:153\u201366. https:\/\/doi.org\/10.1111\/aogs.13702.","DOI":"10.1111\/aogs.13702"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_027","doi-asserted-by":"crossref","unstructured":"Monier, I, Ancel, PY, Ego, A, Guellec, I, Jarreau, PH, Kaminski, M, et al.. Gestational age at diagnosis of early-onset fetal growth restriction and impact on management and survival: a population-based cohort study. BJOG 2017;124:1899\u2013906. https:\/\/doi.org\/10.1111\/1471-0528.14555.","DOI":"10.1111\/1471-0528.14555"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_028","doi-asserted-by":"crossref","unstructured":"Figueras, F, Gratac\u00f3s, E. Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol. Fetal Diagn Ther 2014;36:86\u201398. https:\/\/doi.org\/10.1159\/000357592.","DOI":"10.1159\/000357592"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_029","doi-asserted-by":"crossref","unstructured":"Turan, OM, Turan, S, Gungor, S, Berg, C, Moyano, D, Gembruch, U, et al.. Progression of Doppler abnormalities in intrauterine growth restriction. Ultrasound Obstet Gynecol 2008;32:160\u20137. https:\/\/doi.org\/10.1002\/uog.5386.","DOI":"10.1002\/uog.5386"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_030","doi-asserted-by":"crossref","unstructured":"Lees, CC, Romero, R, Stampalija, T, Dall\u2019Asta, A, DeVore, GA, Prefumo, F, et al.. Clinical Opinion: the diagnosis and management of suspected fetal growth restriction: an evidence-based approach. Am J Obstet Gynecol 2022;226:366\u201378. https:\/\/doi.org\/10.1016\/j.ajog.2021.11.1357.","DOI":"10.1016\/j.ajog.2021.11.1357"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_031","doi-asserted-by":"crossref","unstructured":"Lees, CC, Stampalija, T, Baschat, A, da Silva Costa, F, Ferrazzi, E, Figueras, F, et al.. ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction. Ultrasound Obstet Gynecol 2020;56:298\u2013312. https:\/\/doi.org\/10.1002\/uog.22134.","DOI":"10.1002\/uog.22134"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_032","doi-asserted-by":"crossref","unstructured":"Tyson, JE, Parikh, NA, Langer, J, Green, C, Higgins, RD. National Institute of Child Health and Human Development neonatal Research Network. Intensive care for extreme prematurity--moving beyond gestational age. N\u00a0Engl J Med 2008;358:1672\u201381. https:\/\/doi.org\/10.1056\/NEJMoa073059.","DOI":"10.1056\/NEJMoa073059"},{"key":"2025122009100293478_j_jpm-2025-0078_ref_033","unstructured":"StataCorp. Stata statistical software: release 18. College Station, TX: StataCorp LLC; 2023."},{"key":"2025122009100293478_j_jpm-2025-0078_ref_034","doi-asserted-by":"crossref","unstructured":"Lees, C, Marlow, N, Arabin, B, Bilardo, CM, Brezinka, C, Derks, JB, et al.. Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE). Ultrasound Obstet Gynecol 2013;42:400\u20138. https:\/\/doi.org\/10.1002\/uog.13190.","DOI":"10.1002\/uog.13190"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpm-2025-0078\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpm-2025-0078\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T09:24:29Z","timestamp":1766222669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpm-2025-0078\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":34,"alternative-id":["10.1515\/jpm-2025-0078"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2025-0078","relation":{},"ISSN":["0300-5577","1619-3997"],"issn-type":[{"type":"print","value":"0300-5577"},{"type":"electronic","value":"1619-3997"}],"subject":[],"published":{"date-parts":[[2025,8,22]]}}}