{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:10:02Z","timestamp":1778602202268,"version":"3.51.4"},"reference-count":76,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"This research was funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["\u00d0\u00d0\u00a019678324"],"award-info":[{"award-number":["\u00d0\u00d0\u00a019678324"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0143_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of the study is to explore the potential of novel genetic markers in predicting and diagnosing hypertensive conditions during pregnancy, focusing on their role in key pathological processes. The relevance of this study is determined by the necessity to improve methods for the early detection and effective management of pregnancy complications, particularly those associated with elevated blood pressure, which pose a threat to the health of both mother and foetus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0143_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The research methodology involves a systematic analysis of scientific literature from the past five years, specifically from 2019 to 2024, emphasising the integration of data from various populations and research approaches within the field of molecular medicine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0143_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The main findings demonstrate that certain molecular markers reflecting gene activity exhibit high accuracy in predicting the risks of complications associated with hypertension of pregnancy. It is established that these markers can detect disturbances in the regulation of vascular tone, angiogenesis processes, and inflammatory responses long before the onset of clinical symptoms. This opens up opportunities for timely medical intervention and a personalised approach to pregnancy management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0143_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of the study confirm the potential of utilising genetic markers in clinical practice to improve pregnancy outcomes and reduce risks for both mother and child. The practical value lies in the possibility of developing new screening programmes and therapeutic strategies based on the individual characteristics of patients, contributing to more effective management of hypertensive disorders during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0143","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:56:23Z","timestamp":1760637383000},"page":"467-480","source":"Crossref","is-referenced-by-count":0,"title":["RNA biomarkers in hypertensive disorders of pregnancy: systematic review"],"prefix":"10.1515","volume":"54","author":[{"given":"Damilya","family":"Salimbayeva","sequence":"first","affiliation":[{"name":"Department of Strategic Development and Science, Scientific Centre for Obstetrics , Gynaecology and Perinatology , Almaty , Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulfairuz","family":"Urazbayeva","sequence":"additional","affiliation":[{"name":"Scientific Centre for Obstetrics , Gynaecology and Perinatology , Almaty , Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almagul","family":"Kurmanova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , 98799 Al-Farabi Kazakh National University , Almaty , Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makhambet","family":"Smailov","sequence":"additional","affiliation":[{"name":"Department of Strategic Development and Science, Scientific Centre for Obstetrics , Gynaecology and Perinatology , Almaty , Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altynay","family":"Nurmakova","sequence":"additional","affiliation":[{"name":"Faculty of Postgraduate Education , Asfendiyarov Kazakh National Medical University , Almaty , Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"2026051215133573468_j_jpm-2025-0143_ref_001","doi-asserted-by":"crossref","unstructured":"Ford, N, Cox, S, Ko, J, Ouyang, L, Romero, L, Colarusso, T, et al.. 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