{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:11:54Z","timestamp":1778602314772,"version":"3.51.4"},"reference-count":14,"publisher":"Walter de Gruyter GmbH","issue":"8","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0154_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Preeclampsia is a multisystem syndrome that involves various genetic and environmental factors in its pathogenesis and pathophysiology. Its etiopathogenesis remains to be fully understood. This study aimed to investigate whether the level of pentraxin-3 (PTX3) in maternal peripheral blood during the second and third trimesters can predict its role in the aetiology of preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0154_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study analysed data from 96 mothers who gave birth between September 2020 and 2021 at the Department of Obstetrics at Umraniye Training and Research Hospital. Blood PTX3 levels were measured for each participant. Of 96, 50 preeclampsia patients were in the study group, and 46 normotensive healthy pregnancies were in the control group. The associations between preeclampsia and PTX3 levels were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0154_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 96 pregnant women were evaluated. The overall mean age was 28.9\u00a0\u00b1\u00a06.4years. As compared with mothers with healthy women, preeclampsia women had significantly a higher PTX3 level (5.919\u202fng\/mL vs. 2.828\u202fng\/mL, respectively; p=0.0001) in maternal peripheral blood. In addition, the PTX3 level was similar among varying forms of preeclampsia (p&gt;0.05). In ROC analysis, the cut-off value for Pentraxin-3 to predict preeclampsia was established at 4.16\u202fng\/mL, with a sensitivity of 95.9\u202f%, a specificity of 97.8\u202f%, a PPV of 97.9\u202f% and an NPV of 95.7\u202f%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0154_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest the expression of PTX3 in the peripheral blood was associated with the pathogenesis of PE. The PTX3 may prove useful in predicting preeclampsia in women with a PTX3 level higher than 4.16\u202fng\/mL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0154","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:20:33Z","timestamp":1760098833000},"page":"1048-1053","source":"Crossref","is-referenced-by-count":1,"title":["Pentraxins 3 levels in pregnant women diagnosed with preeclampsia and their relationship with the severity of the condition"],"prefix":"10.1515","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-6356","authenticated-orcid":false,"given":"G\u00fcne\u015f","family":"Topcu","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department , 147021 Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-4923","authenticated-orcid":false,"given":"Adil","family":"Barut","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department , Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0747-4990","authenticated-orcid":false,"given":"P\u0131nar","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department , 147021 Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6247-2383","authenticated-orcid":false,"given":"\u00c7a\u011flar","family":"Helvac\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department , 147021 Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-375X","authenticated-orcid":false,"given":"Murat","family":"Muhcu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department , 147021 Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7558-1451","authenticated-orcid":false,"given":"Mahmut","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department , Ministry of Health Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Yenimahalle Education and Research Hospital , Ankara , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"2026051215163778863_j_jpm-2025-0154_ref_001","doi-asserted-by":"crossref","unstructured":"Garovic, VD, Dechend, R, Easterling, T, Karumanchi, SA, McMurtry Baird, S, Magee, LA, et al.. 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J\u00a0Matern Fetal Neonatal Med 2022;35:299\u2013307. https:\/\/doi.org\/10.1080\/14767058.2020.1716718.","DOI":"10.1080\/14767058.2020.1716718"},{"key":"2026051215163778863_j_jpm-2025-0154_ref_012","doi-asserted-by":"crossref","unstructured":"Tanr\u0131verdi K\u0131l\u0131\u00e7, G, Yenig\u00fcl, NN, Din\u00e7gez, B, Y\u00fcce Bilgin, E, K\u0131l\u0131\u00e7, \u00dcK. The role of pentraxin 3 and cathepsin B levels in pregnancies complicated by\u00a0preeclampsia. Biomarkers 2024;29:518\u201327. https:\/\/doi.org\/10.1080\/1354750x.2024.2421884.","DOI":"10.1080\/1354750X.2024.2421884"},{"key":"2026051215163778863_j_jpm-2025-0154_ref_013","doi-asserted-by":"crossref","unstructured":"Boldeanu, L, V\u0103duva, CC, Caragea, DC, Novac, MB, Manasia, M, Silo\u015fi, I, et al.. Association between serum 8-iso-prostaglandin F2\u03b1 as an oxidative stress marker and immunological markers in a cohort of preeclampsia patients. 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