{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T09:29:43Z","timestamp":1766222983043,"version":"3.48.0"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0198_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Hydrops fetalis is associated with high morbidity and perinatal mortality. The aim of our study was to compare the outcomes of infants who had non-immune hydrops fetalis (NIHF) who did or did not undergo antenatal shunting\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0198_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between January 2014 and June 2023, 20 infants with the diagnosis of NIHF were admitted to the neonatal intensive care unit (NICU) at King\u2019s College Hospital NHS Foundation Trust. The criteria for antenatal shunt placement were development of hydrops fetalis, polyhydramnios due to oesophageal compression by a pleural effusion that would likely result in preterm labour or a large pleural effusion (no hydrops at presentation) resulting in likely inferior vena cava compression and significant risk of development of hydrops.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0198_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 20 infants had a median gestational age of 34 (27\u201340) weeks of gestation at delivery and were diagnosed at a median gestational age of 29 (17\u201340) weeks. Eight infants had a shunt inserted antenatally (six pleuro amniotic and two abdominal amniotic) and they delivered at a significantly later median gestational age (36 vs. 32.5\u00a0weeks, p=0.025). After adjustment for gestational age at delivery and antenatal severity, those who had a shunt placed were not more likely to be oxygen dependent at 36\u00a0weeks post menstrual age (PMA) and had a lower length of stay (23 vs. 95\u00a0days, p=0.019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0198_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Infants who had NIHF and had antenatal shunting had favourable outcomes compared to those who did not, despite a more severe antenatal presentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0198","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T04:55:27Z","timestamp":1756097727000},"source":"Crossref","is-referenced-by-count":0,"title":["Antenatal shunting and outcomes in fetuses with non-immune hydrops fetalis"],"prefix":"10.1515","author":[{"given":"Valentina","family":"Fragala","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit , King\u2019s College Hospital NHS Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Sabale","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , King\u2019s College Hospital NHS Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghalia","family":"Ashoor","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , King\u2019s College Hospital NHS Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Harris","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , King\u2019s College Hospital NHS Trust , London , UK"},{"name":"Faculty of Life Sciences and Medicine , King\u2019s College London , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Zorro","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , King\u2019s College Hospital NHS Trust , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-5349","authenticated-orcid":false,"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit , King\u2019s College Hospital NHS Trust , London , UK"},{"name":"Faculty of Life Sciences and Medicine , King\u2019s College London , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"2025122009101127544_j_jpm-2025-0198_ref_001","doi-asserted-by":"crossref","unstructured":"Kilby, MD. Nonimmune hydrops fetalis - more than Meets the Eye? N\u00a0Engl J Med 2020;383:1785\u20136. https:\/\/doi.org\/10.1056\/nejme2029914.","DOI":"10.1056\/NEJMe2029914"},{"key":"2025122009101127544_j_jpm-2025-0198_ref_002","doi-asserted-by":"crossref","unstructured":"Swearingen, C, Colvin, ZA, Leuthner, SR. Nonimmune hydrops fetalis. Clin Perinatol 2020;47:105\u201321. https:\/\/doi.org\/10.1016\/j.clp.2019.10.001.","DOI":"10.1016\/j.clp.2019.10.001"},{"key":"2025122009101127544_j_jpm-2025-0198_ref_003","doi-asserted-by":"crossref","unstructured":"Younge, T, Ottolini, KM, Al-Kouatly, HB, Berger, SI. Hydrops fetalis: Incidence, Etiologies, management Strategies, and outcomes hydrops fetalis: Incidence, Etiologies, management Strategies, and outcomes. Res Rep Neonatol 2023;13:81\u201392. https:\/\/doi.org\/10.2147\/rrn.s411736.","DOI":"10.2147\/RRN.S411736"},{"key":"2025122009101127544_j_jpm-2025-0198_ref_004","doi-asserted-by":"crossref","unstructured":"Yinon, Y, Kelly, E, Ryan, G. 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