{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:49:07Z","timestamp":1793321347582,"version":"4.5.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0229_abs_001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality, driven by oxidative stress, endothelial dysfunction, and systemic inflammation. Current preventive strategies, such as low-dose aspirin, offer modest benefit, highlighting the need for alternative approaches. Medicinal plants with antioxidant and anti-inflammatory properties, long used in maternal health traditions, may provide biological pathways relevant to preeclampsia prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0229_abs_002\">\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>\n                      This review synthesizes human clinical and mechanistic evidence on four medicinal plants with documented antioxidant activity\u00a0\u2013\u00a0\n                      <jats:italic>Curcuma longa<\/jats:italic>\n                      ,\n                      <jats:italic>Moringa oleifera<\/jats:italic>\n                      ,\n                      <jats:italic>Orthosiphon aristatus<\/jats:italic>\n                      , and\n                      <jats:italic>Centella asiatica<\/jats:italic>\n                      . These botanicals demonstrate potential mechanisms of action including redox modulation, preservation of endothelial function, and suppression of pro-inflammatory pathways, all of which are implicated in preeclampsia pathophysiology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0229_abs_003\">\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>A PRISMA-guided systematic search of PubMed, Scopus, Web of Science, and the Cochrane Library (2000\u20132025) identified human studies evaluating these plants\u2019 effects on oxidative stress and vascular health. Evidence was synthesized narratively due to heterogeneous study designs and outcomes. Most studies were small, often not pregnancy-specific, and used non-standardized botanical formulations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0229_abs_004\">\n                    <jats:title>Outlook<\/jats:title>\n                    <jats:p>These medicinal plants offer biologically plausible pathways to reduce preeclampsia risk. However, pregnancy-focused randomized trials, dose optimization, pharmacokinetic profiling, and safety evaluations are essential before clinical integration into maternal\u00a0care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0229","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T02:55:50Z","timestamp":1758596150000},"page":"658-672","source":"Crossref","is-referenced-by-count":3,"title":["Plant-based antioxidant strategies with potential for preeclampsia prevention: clinical and mechanistic insights"],"prefix":"10.1515","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9062-8501","authenticated-orcid":false,"given":"Wiku","family":"Andonotopo","sequence":"first","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , 648394 Women Health Center, Ekahospital BSD City , Tangerang , Banten , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-3909","authenticated-orcid":false,"given":"Muhammad Adrianes","family":"Bachnas","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Sebelas Maret University, Dr. Moewardi Hospital, Solo , Surakarta , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Dewantiningrum","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Central Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mochammad Besari","family":"Adi Pramono","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Central Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresia Monica","family":"Rahardjo","sequence":"additional","affiliation":[{"name":"Maranatha Christian University, Faculty of Medicine , Bandung , West Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aloysius","family":"Suryawan","sequence":"additional","affiliation":[{"name":"Maranatha Christian University, Faculty of Medicine , Bandung , West Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bambang","family":"Rahardjo","sequence":"additional","affiliation":[{"name":"Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology , Faculty of Medicine, Brawijaya University, Dr. Saiful Anwar General Hospital , Malang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Nyoman","family":"Hariyasa Sanjaya","sequence":"additional","affiliation":[{"name":"Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology , Faculty of Medicine, Udayana University, Prof. Dr. I.G.N.G Ngoerah General Hospital , Bali , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri","family":"Sulistyowati","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Sebelas Maret University, Dr. Moewardi Hospital, Solo , Surakarta , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Stanojevic","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Rare Diseases , Medical University of Warsaw , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Kurjak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Medical School University of Zagreb , Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"2026050821281506699_j_jpm-2025-0229_ref_001","doi-asserted-by":"crossref","unstructured":"Mol, BWJ, Roberts, CT, Thangaratinam, S, Magee, LA, de Groot, CJM, Hofmeyr, GJ. 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