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This previously unrecognized possible cause of chronic and recurrent fetal, placental and myometrial hypoxia might be detected and corrected using \u201ccardiac output-guided maternal positioning,\u201d since positional obstruction of the inferior vena cava causes a positional decrease in maternal cardiac output (CO). These positional decreases in CO may therefore constitute an actionable warning signal for a pregnant woman to change her body position and thereby restore optimal uterine perfusion and fetal oxygenation. Continuous, non-invasive and hands-free trending of maternal CO is now feasible in real\u00a0time\u00a0in order to detect this warning signal in real time. Further research is required to evaluate this hypothesis, and if it is valid, the approach and therapy proposed might constitute a breakthrough for preventing some complications of pregnancy.<\/jats:p>","DOI":"10.1515\/jpm-2025-0333","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:58:52Z","timestamp":1759229932000},"page":"23-41","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac output-guided maternal positioning may protect the fetal oxygen supply and thereby reduce pregnancy complications"],"prefix":"10.1515","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7816-2750","authenticated-orcid":false,"given":"Thomas L.","family":"Archer","sequence":"first","affiliation":[{"name":"Department of Anesthesiology , 8784 University of California San Diego , La Jolla , California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"2026053006093729193_j_jpm-2025-0333_ref_001","doi-asserted-by":"crossref","unstructured":"Burton, GJ, Cindrova-Davies, T, Yung, HW, Jauniaux, E. 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