{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:12:57Z","timestamp":1778602377928,"version":"3.51.4"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0336_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the association between Doppler ultrasonographic parameters and maternal serum bile acid levels in pregnancies complicated by intrahepatic cholestasis of pregnancy (ICP) and to evaluate their potential role in fetal monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0336_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective observational study, 59 pregnant women diagnosed with ICP and 59 healthy controls\u00a0were included. The diagnosis of ICP was based on pruritus and serum bile acid levels &gt;10\u202f\u03bcmol\/L. Doppler assessments\u00a0\u2013 performed by a blinded perinatologist \u2013 included the uterine artery pulsatility index (PI), middle cerebral artery (MCA) PI,\u00a0umbilical artery (UA) PI, and cerebroplacental ratio (CPR).\u00a0Participants were further stratified by bile acid levels (&lt;10, 10\u201340, &gt;40\u202f\u03bcmol\/L), and intergroup comparisons and correlation analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0336_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ICP cases had significantly higher uterine artery PI and lower MCA PI and CPR values compared to controls (p&lt;0.05). Bile acid levels were positively correlated with uterine artery PI and inversely correlated with MCA PI and CPR. ICP pregnancies also demonstrated increased rates of preterm delivery, low birth weight, and neonatal intensive care unit (NICU) admissions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0336_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Alterations in uterine and fetal Doppler indices in ICP pregnancies suggest underlying placental dysfunction. These findings support the clinical utility of Doppler ultrasound in the risk stratification and perinatal surveillance of patients with\u00a0ICP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0336","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:05:21Z","timestamp":1759579521000},"page":"333-339","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Doppler parameters and obstetric outcomes in intrahepatic cholestasis of pregnancy"],"prefix":"10.1515","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6496-5984","authenticated-orcid":false,"given":"M\u00fcmine Eda","family":"\u015e\u0131k","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics , Cemil Ta\u015fc\u0131o\u011flu City Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-1642","authenticated-orcid":false,"given":"Mira\u00e7","family":"\u00d6zalp","sequence":"additional","affiliation":[{"name":"Department of Perinatology , Liv Hospital Ulus , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1358-9099","authenticated-orcid":false,"given":"Murat \u0130brahim","family":"Toplu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Cemil Ta\u015fc\u0131o\u011flu City Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8701-8462","authenticated-orcid":false,"given":"Veli","family":"Mihmanl\u0131","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Cemil Ta\u015fc\u0131o\u011flu City Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"2026051215204218102_j_jpm-2025-0336_ref_001","unstructured":"Pillarisetty, LSSA. Pregnancy intrahepatic cholestasis. In: StatPearls [Internet]. 2025 Jan. Aufl. Treasure Island (FL). StatPearls Publishing; 2023."},{"key":"2026051215204218102_j_jpm-2025-0336_ref_002","doi-asserted-by":"crossref","unstructured":"Sadeghi, A. Global incidence of intrahepatic cholestasis of pregnancy: a protocol for systematic review and meta-analysis. Health Sci Rep 2024;7:e1901. https:\/\/doi.org\/10.1002\/hsr2.1901.","DOI":"10.1002\/hsr2.1901"},{"key":"2026051215204218102_j_jpm-2025-0336_ref_003","doi-asserted-by":"crossref","unstructured":"Z\u00f6llner, J, Williamson, C, Dixon, PH. Genetic issues in ICP. Obstet Med 2024;17:157\u201361. https:\/\/doi.org\/10.1177\/1753495x241263441.","DOI":"10.1177\/1753495X241263441"},{"key":"2026051215204218102_j_jpm-2025-0336_ref_004","doi-asserted-by":"crossref","unstructured":"Manzotti, C, Casazza, G, Stimac, T, Nikolova, D, Gluud, C. 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