{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:25:11Z","timestamp":1791289511837,"version":"4.3.0"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0353_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to evaluate the association between maternal cardiovascular function, umbilical vein blood flow (UV-Q), and impaired fetal growth in pregnancies complicated by gestational diabetes mellitus (GDM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0353_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective observational study, 84 singleton pregnancies complicated by GDM between 28 and 32\u00a0weeks of gestation were enrolled. All participants underwent a standardized maternal hemodynamic assessment using USCOM device and fetal ultrasound including Doppler-based measurement of UV-Q. Impaired fetal growth was defined as either small for gestational age (SGA, birthweight &lt;10th centile) or a\u00a0\u226540 centile drop between estimated fetal weight (EFW) at enrolment and actual birthweight centile (\u201cDROP\u201d). Predictive performance was assessed using ROC analysis and multivariate logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0353_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fetuses with impaired growth (n=24) had significantly lower UV-Q centiles (median 29.50 vs. 50.00, p=0.04), higher maternal systemic vascular resistance (SVR) (1,004.50 vs. 915.00\u202fdyn\u202fs\u202fcm\n                      <jats:sup>\u22125<\/jats:sup>\n                      , p&lt;0.01), lower cardiac output (CO) (6.5 vs. 7.2\u202fL\/min, p=0.03), and reduced oxygen delivery (DO\n                      <jats:sub>2<\/jats:sub>\n                      ) (1,021.22 vs. 1,131.06 mL\/min, p&lt;0.01) compared to those with normal growth. Multivariate analysis identified UV-Q centile\u00a0\u226424, SVR&gt;916\u202fdyn\u202fs\u202fcm\n                      <jats:sup>\u22125<\/jats:sup>\n                      , and DO\n                      <jats:sub>2<\/jats:sub>\n                      \u22641,061.4 as independent predictors of impaired growth (AUC up to 0.78). These associations remained significant after adjusting for EFW at enrolment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0353_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In pregnancies complicated by GDM, impaired fetal growth may reflect placental dysfunction and maternal cardiovascular maladaptation. Maternal hemodynamic parameters and UV-Q may enhance fetal growth surveillance, particularly when incorporating longitudinal metrics such as DROP. These findings suggest a potential role for integrating maternal-fetal hemodynamics into standard care to identify \u201chidden\u201d growth restriction phenotypes in GDM pregnancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0353","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:55:48Z","timestamp":1763456148000},"page":"51-60","source":"Crossref","is-referenced-by-count":5,"title":["Umbilical venous flow and maternal hemodynamics as predictors of impaired fetal growth in gestational diabetes: a prospective study"],"prefix":"10.1515","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-659X","authenticated-orcid":false,"given":"Daniele","family":"Farsetti","sequence":"first","affiliation":[{"name":"University of Rome Tor Vergata , Rome , Italy"},{"name":"Obstetrics and Gynecology , Policlinico Casilino , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Nardini","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology , Policlinico Casilino , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Maffi","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology , Policlinico Casilino , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Frantellizzi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology , Policlinico Casilino , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pometti","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata , Rome , Italy"},{"name":"Obstetrics and Gynecology , Policlinico Casilino , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Vasapollo","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata , Rome , Italy"},{"name":"Obstetrics and Gynecology , Policlinico Casilino , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Paolo","family":"Novelli","sequence":"additional","affiliation":[{"name":"Cardiology , Fondazione PTV Policlinico Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Valensise","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata , Rome , Italy"},{"name":"Obstetrics and Gynecology , Policlinico Casilino , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"2026053007045652488_j_jpm-2025-0353_ref_001","doi-asserted-by":"crossref","unstructured":"Fasoulakis, Z, Koutras, A, Antsaklis, P, Theodora, M, Valsamaki, A, Daskalakis, G, et al.. 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