{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T07:02:26Z","timestamp":1780124546816,"version":"3.54.0"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0356_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The SARS-CoV-2 pandemic was declared by World Health Organisation (WHO) in March 2020, causing health and economic disruptions and millions of deaths. Pregnant women represent a vulnerable group, as COVID-19 during pregnancy increases the risk of preterm birth, preeclampsia, and severe maternal illness. Nutritional status, such as vitamin D deficiency, may influence these outcomes, yet data on its status in the cohort of SARS-CoV-2 positive pregnant women as well as its association with inflammatory and angiogenic markers is scarce. The aim of this study was to evaluate the levels of vitamin D in the cohort of SARS-CoV-2 positive pregnant women and its association with inflammatory and angiogenic markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0356_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective cohort study at Ljubljana Maternity Hospital (Oct 1, 2020\u2013Mar 30, 2021) enrolled singleton pregnancies with PCR-confirmed SARS-CoV-2 within the last 14\u202fdays, delivering at our institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0356_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 235 SARS-CoV-2-positive pregnant women 62.1\u202f% had adequate and 21.3\u202f% insufficient level of vitamin D and 13.6\u202f% were vitamin D deficient. Statistical analysis revealed no significant correlations between 25-OH-vitamin D and C-reactive protein (CRP), procalcitonin (PCT), leukocyte count, soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), the sFlt-1\/PlGF ratio, or body mass index (BMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0356_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our prospective cohort study revealed that high proportion of pregnant women has inadequate levels of vitamin D. Although maternal insufficiency is linked to adverse outcomes, its association with inflammatory and angiogenic markers remains unclear. Rigorous studies in pregnancy are essential to clarify vitamin D\u2019s role in COVID-19 complications in pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0356","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T04:56:31Z","timestamp":1764046591000},"page":"183-188","source":"Crossref","is-referenced-by-count":1,"title":["Serum vitamin D and inflammatory markers in SARS-CoV-2 positive pregnant women"],"prefix":"10.1515","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1214-344X","authenticated-orcid":false,"given":"Vita Andreja","family":"Mesari\u010d","sequence":"first","affiliation":[{"name":"Department of Perinatology, Division of Gynaecology and Obstetrics , University Medical Centre Ljubljana , Ljubljana , Slovenia"},{"name":"Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Premru Sr\u0161en","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Gynaecology and Obstetrics , University Medical Centre Ljubljana , Ljubljana , Slovenia"},{"name":"Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorazd","family":"Kav\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Gynaecology and Obstetrics , University Medical Centre Ljubljana , Ljubljana , Slovenia"},{"name":"Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Verdenik","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Gynaecology and Obstetrics , University Medical Centre Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"\u0160trukelj","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Gynaecology and Obstetrics , University Medical Centre Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Dru\u0161kovi\u010d","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Gynaecology and Obstetrics , University Medical Centre Ljubljana , Ljubljana , Slovenia"},{"name":"Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"2026053006283910039_j_jpm-2025-0356_ref_001","doi-asserted-by":"crossref","unstructured":"Wang, M-Y, Zhao, R, Gao, L-J, Gao, X-F, Wang, D-P, Cao, J-M. 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Acta Biochim Pol 2024;71. https:\/\/doi.org\/10.3389\/abp.2024.13108.","DOI":"10.3389\/abp.2024.13108"},{"key":"2026053006283910039_j_jpm-2025-0356_ref_021","doi-asserted-by":"crossref","unstructured":"\u00c1lvarez-Fern\u00e1ndez, I, Prieto, B, Rodr\u00edguez, V, Ruano, Y, Escudero, AI, \u00c1lvarez, FV. Role of vitamin D and sFlt-1\/PlGF ratio in the development of early- and late-onset preeclampsia. Clin Chem Lab Med 2015;53:1033\u201340. https:\/\/doi.org\/10.1515\/cclm-2014-1039.","DOI":"10.1515\/cclm-2014-1039"},{"key":"2026053006283910039_j_jpm-2025-0356_ref_022","doi-asserted-by":"crossref","unstructured":"Karras, SN, Fakhoury, H, Muscogiuri, G, Grant, WB, van den Ouweland, JM, Colao, AM, et al.. Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications. 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