{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:17:23Z","timestamp":1791227843214,"version":"4.1.0"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0398_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the additional diagnostic value of fetal magnetic resonance imaging (MRI) compared to prenatal ultrasonography (US) in fetal anomaly evaluation, using postnatal confirmation as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0398_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cross-sectional study, we evaluated 104 fetal cases who underwent fetal MRI following suspicious or abnormal second- or third-trimester US findings between January 2022 and January 2025. US and MRI findings were compared, and diagnostic concordance was categorized. Postnatal confirmation was based on imaging, surgical, clinical, or pathological follow-up. Diagnostic accuracy rates were calculated using postnatal outcomes as the gold standard, and modality agreement was assessed using the kappa coefficient and McNemar\u00a0test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0398_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postnatal confirmation data were available for 99 of the 104 cases, comprising 149 anomalies. MRI and US showed complete agreement in 79.8\u202f% of cases. MRI provided additional diagnostic information over US in 10.6\u202f% and showed discrepant findings in 9.6\u202f%. Postnatal data confirmed that US correctly diagnosed 76.8\u202f% of cases, while MRI reached 92.9\u202f% diagnostic accuracy, a statistically significant difference (p=0.0015). The agreement between modalities was moderate (\u03ba=0.54). MRI notably enhanced diagnostic accuracy, especially for central nervous system anomalies, and influenced postnatal clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0398_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fetal MRI significantly improves prenatal diagnostic accuracy over US, particularly in complex or ambiguous cases, with the most significant added value seen in central nervous system pathologies. Its complementary role enhances prenatal counseling and postnatal planning. Larger multicenter studies are warranted to evaluate its contribution across different organ systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0398","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:05:21Z","timestamp":1767859521000},"page":"381-390","source":"Crossref","is-referenced-by-count":3,"title":["The additional value of fetal MRI to ultrasonography in prenatal diagnosis: an evaluation based on postnatal confirmation"],"prefix":"10.1515","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3741-1044","authenticated-orcid":false,"given":"Elif","family":"Yasar","sequence":"first","affiliation":[{"name":"Department of Radiology , University of Health Sciences \u015eehit Prof. Dr. Ilhan Varank Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-3924","authenticated-orcid":false,"given":"Ozge","family":"Kahramanoglu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Health Sciences \u015eehit Prof. Dr. Ilhan Varank Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-1913","authenticated-orcid":false,"given":"Cigdem","family":"Kunt Isguder","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Health Sciences \u015eehit Prof. Dr. Ilhan Varank Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7917-3534","authenticated-orcid":false,"given":"Nur Betul","family":"Unal Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Radiology , University of Health Sciences \u015eehit Prof. Dr. Ilhan Varank Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-7681","authenticated-orcid":false,"given":"Yunus","family":"Yasar","sequence":"additional","affiliation":[{"name":"Department of Radiology , University of Health Sciences Umraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7420-1484","authenticated-orcid":false,"given":"Koray","family":"Gok","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"2026051215204228087_j_jpm-2025-0398_ref_001","doi-asserted-by":"crossref","unstructured":"Paladini, D, Malinger, G, Birnbaum, R, Monteagudo, A, Pilu, G, Salomon, LJ, et al.. ISUOG practice guidelines (updated): sonographic examination of the fetal central nervous system. Part 2: performance of targeted neurosonography. Ultrasound Obstet Gynecol 2021;57:661\u201371. https:\/\/doi.org\/10.1002\/uog.23616.","DOI":"10.1002\/uog.23616"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_002","doi-asserted-by":"crossref","unstructured":"Cederlund, F, Axelsson, O, Desmond, S, Amini, H, Wikstr\u00f6m, J. Magnetic resonance imaging in the second trimester as a complement to ultrasound for diagnosis of fetal anomalies. Acta Radiol Open 2024;13. https:\/\/doi.org\/10.1177\/20584601241248820.","DOI":"10.1177\/20584601241248820"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_003","doi-asserted-by":"crossref","unstructured":"Prayer, D, Malinger, G, De Catte, L, De Keersmaecker, B, Gon\u00e7alves, LF, Kasprian, G, et al.. ISUOG practice guidelines (updated): performance of fetal magnetic resonance imaging. Ultrasound Obstet Gynecol 2023;61:278\u201387. https:\/\/doi.org\/10.1002\/uog.26129.","DOI":"10.1002\/uog.26129"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_004","doi-asserted-by":"crossref","unstructured":"Weston, MJ. Magnetic resonance imaging in fetal medicine: a pictorial review of current and developing indications. Postgrad Med J 2010;86:42\u201351. https:\/\/doi.org\/10.1136\/pgmj.2009.083543.","DOI":"10.1136\/pgmj.2009.083543"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_005","doi-asserted-by":"crossref","unstructured":"Rathee, S, Joshi, P, Kelkar, A, Seth, N. Fetal MRI: a pictorial essay. Indian J Radiol Imag 2016;26:52\u201362. https:\/\/doi.org\/10.4103\/0971-3026.178326.","DOI":"10.4103\/0971-3026.178326"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_006","doi-asserted-by":"crossref","unstructured":"Masselli, G, Vaccaro Notte, MR, Zacharzewska-Gondek, A, Laghi, F, Manganaro, L, Brunelli, R. Fetal MRI of CNS abnormalities. Clin Radiol 2020;75:640.e1\u2013640.e11. https:\/\/doi.org\/10.1016\/j.crad.2020.03.035.","DOI":"10.1016\/j.crad.2020.03.035"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_007","doi-asserted-by":"crossref","unstructured":"Glenn, OA. MR imaging of the fetal brain. Pediatr Radiol 2010;40:68\u201381. https:\/\/doi.org\/10.1007\/s00247-009-1459-3.","DOI":"10.1007\/s00247-009-1459-3"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_008","doi-asserted-by":"crossref","unstructured":"Conte, G, Parazzini, C, Falanga, G, Cesaretti, C, Izzo, G, Rustico, M, et al.. Diagnostic value of prenatal MR imaging in the detection of brain malformations in fetuses before the 26th week of gestational age. Am J Neuroradiol 2016;37:946\u201351. https:\/\/doi.org\/10.3174\/ajnr.a4639.","DOI":"10.3174\/ajnr.A4639"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_009","doi-asserted-by":"crossref","unstructured":"Recio Rodr\u00edguez, M, Andreu-V\u00e1zquez, C, Thuissard-Vasallo, IJ, Cano Alonso, R, Bermejo L\u00f3pez, C, Tamarit Degenhardt, I, et al.. Real-life diagnostic accuracy of mri in prenatal diagnosis. Radiol Res Pract 2020;2020:1\u201312. https:\/\/doi.org\/10.1155\/2020\/4085349.","DOI":"10.1155\/2020\/4085349"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_010","doi-asserted-by":"crossref","unstructured":"Rossi, AC, Prefumo, F. Additional value of fetal magnetic resonance imaging in the prenatal diagnosis of central nervous system anomalies: a systematic review of the literature. Ultrasound Obstet Gynecol 2014;44:388\u201393. https:\/\/doi.org\/10.1002\/uog.13429.","DOI":"10.1002\/uog.13429"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_011","doi-asserted-by":"crossref","unstructured":"Herrera, CL, Byrne, JJ, Clark, HR, Twickler, DM, Dashe, JS. Use of fetal magnetic resonance imaging after sonographic identification of major structural anomalies. J\u00a0Ultrasound Med 2020;39:2053\u20138. https:\/\/doi.org\/10.1002\/jum.15313.","DOI":"10.1002\/jum.15313"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_012","doi-asserted-by":"crossref","unstructured":"Griffiths, PD, Bradburn, M, Campbell, MJ, Cooper, CL, Graham, R, Jarvis, D, et al.. Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study. Lancet 2017;389:538\u201346. https:\/\/doi.org\/10.1016\/s0140-6736(16)31723-8.","DOI":"10.1016\/S0140-6736(16)31723-8"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_013","doi-asserted-by":"crossref","unstructured":"Verburg, B, Fink, AM, Reidy, K, Palma-Dias, R. The contribution of MRI after fetal anomalies have been diagnosed by ultrasound: correlation with postnatal outcomes. Fetal Diagn Ther 2015;38:186\u201394. https:\/\/doi.org\/10.1159\/000380821.","DOI":"10.1159\/000380821"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_014","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves, LF, Lee, W, Mody, S, Shetty, A, Sangi-Haghpeykar, H, Romero, R. Diagnostic accuracy of ultrasonography and magnetic resonance imaging for the detection of fetal anomalies: a blinded case-control study. Ultrasound Obstet Gynecol 2016;48:185\u201392. https:\/\/doi.org\/10.1002\/uog.15774.","DOI":"10.1002\/uog.15774"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_015","doi-asserted-by":"crossref","unstructured":"Jarvis, D, Mooney, C, Cohen, J, Papaioannou, D, Bradburn, M, Sutton, A, et al.. A systematic review and meta-analysis to determine the contribution of MR imaging to the diagnosis of foetal brain abnormalities In Utero. Eur Radiol 2017;27:2367\u201380. https:\/\/doi.org\/10.1007\/s00330-016-4563-4.","DOI":"10.1007\/s00330-016-4563-4"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_016","doi-asserted-by":"crossref","unstructured":"van Doorn, M, Oude Rengerink, K, Newsum, EA, Reneman, L, Majoie, CB, Pajkrt, E. Added value of fetal MRI in fetuses with suspected brain abnormalities on neurosonography: a systematic review and meta-analysis. J\u00a0Matern Fetal Neonatal Med 2016;29:2949\u201361. https:\/\/doi.org\/10.3109\/14767058.2015.1109621.","DOI":"10.3109\/14767058.2015.1109621"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_017","doi-asserted-by":"crossref","unstructured":"Turkyilmaz, G, Sarac Sivrikoz, T, Erturk, E, Ozcan, N, Tatl\u0131, B, Karaman, B, et al.. Utilization of neurosonography for evaluation of the corpus callosum malformations in the era of fetal magnetic resonance imaging. J\u00a0Obstet Gynaecol Res 2019;45:1472\u20138. https:\/\/doi.org\/10.1111\/jog.13995.","DOI":"10.1111\/jog.13995"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_018","doi-asserted-by":"crossref","unstructured":"Abbas, HM, Hamed, ST, Gaafar, HM, Amer, MM, Sayed, SB. Additive value of fetal MRI to different ultrasound modalities in diagnosis of fetal GIT and abdominal wall anomalies. Egypt J Radiol Nucl Med 2023;54:59. https:\/\/doi.org\/10.1186\/s43055-023-00997-z.","DOI":"10.1186\/s43055-023-00997-z"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_019","doi-asserted-by":"crossref","unstructured":"Pardy, C, D\u2019Antonio, F, Khalil, A, Giuliani, S. Prenatal detection of esophageal atresia: a systematic review and meta\u2010analysis. Acta Obstet Gynecol Scand 2019;98:689\u201399. https:\/\/doi.org\/10.1111\/aogs.13536.","DOI":"10.1111\/aogs.13536"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_020","doi-asserted-by":"crossref","unstructured":"Beydon, N, Larroquet, M, Coulomb, A, Jouannic, JM, Ducou le Pointe, H, Cl\u00e9ment, A, et al.. Comparison between US and MRI in the prenatal assessment of lung malformations. Pediatr Radiol 2013;43:685\u201396. https:\/\/doi.org\/10.1007\/s00247-012-2596-7.","DOI":"10.1007\/s00247-012-2596-7"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_021","doi-asserted-by":"crossref","unstructured":"Di\u0307\u0307n\u00e7, G, \u00d6zt\u00fcrk, D. Congenital thoracic abnormalities: contribution of prenatal magnetic resonance imaging to ultrasound diagnosis. Sakarya Med J 2021;11:724\u201331.","DOI":"10.31832\/smj.798874"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_022","doi-asserted-by":"crossref","unstructured":"Wilson, L, Whitby, EH. The value of fetal magnetic resonance imaging in diagnosis of congenital anomalies of the fetal body: a systematic review and meta-analysis. BMC Med Imag 2024;24:111. https:\/\/doi.org\/10.1186\/s12880-024-01286-5.","DOI":"10.1186\/s12880-024-01286-5"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_023","doi-asserted-by":"crossref","unstructured":"Meshaka, R, Gaunt, T, Shelmerdine, SC. Artificial intelligence applied to fetal MRI: a scoping review of current research. Br J Radiol 2022;95:20211205. https:\/\/doi.org\/10.1259\/bjr.20211205.","DOI":"10.1259\/bjr.20211205"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_024","doi-asserted-by":"crossref","unstructured":"She, J, Huang, H, Ye, Z, Huang, W, Sun, Y, Liu, C, et al.. Automatic biometry of fetal brain MRIs using deep and machine learning techniques. Sci Rep 2023;13:17860. https:\/\/doi.org\/10.1038\/s41598-023-43867-4.","DOI":"10.1038\/s41598-023-43867-4"},{"key":"2026051215204228087_j_jpm-2025-0398_ref_025","doi-asserted-by":"crossref","unstructured":"Vahedifard, F, Ai, HA, Supanich, MP, Marathu, KK, Liu, X, Kocak, M, et al.. Automatic ventriculomegaly detection in fetal brain MRI: a step-by-step deep learning model for novel 2D-3D linear measurements. Diagnostics 2023;13:2355. https:\/\/doi.org\/10.3390\/diagnostics13142355.","DOI":"10.3390\/diagnostics13142355"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpm-2025-0398\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpm-2025-0398\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:37:51Z","timestamp":1778600271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jpm-2025-0398\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,11,19]]},"published-print":{"date-parts":[[2026,2,24]]}},"alternative-id":["10.1515\/jpm-2025-0398"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2025-0398","relation":{},"ISSN":["0300-5577","1619-3997"],"issn-type":[{"value":"0300-5577","type":"print"},{"value":"1619-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]}}}