{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:14:06Z","timestamp":1792588446363,"version":"4.5.0"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"8","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0706_abs_001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Although inflammasome activation has been repeatedly linked to preeclampsia, the field has tended to frame this biology around NLRP3 alone, leaving other sensors\u00a0\u2013\u00a0particularly NLRP1\u00a0\u2013\u00a0and their mitochondrial upstream signals only partially examined. Recent experimental work hints at a more intricate narrative in which dysregulated BNIP3-mediated mitophagy and escalating mitochondrial ROS form a convergent pathway toward trophoblast injury. Yet no systematic review has stitched these elements together.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0706_abs_002\">\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>Following PRISMA 2020 guidance, we synthesized evidence across experimental, observational, and mechanistic studies, mapping how impaired mitochondrial quality control, oxidative stress, and inflammasome signaling intersect within the placenta and maternal vasculature. The retrieved literature was analyzed for methodological transparency and biological coherence, allowing a layered reconstruction of how BNIP3 overexpression, mitophagy failure, and mtROS collectively prime NLRP1 activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0706_abs_003\">\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Across 31 eligible studies, a consistent picture emerged: mitochondrial injury acts less as a by-product and more as a central instigator of the inflammatory cascade that\u00a0shapes the preeclampsia phenotype. The BNIP3\u2192mtROS\u2192NLRP1 axis appears particularly relevant, even when data are fragmented or derived from heterogeneous models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0706_abs_004\">\n                    <jats:title>Outlook<\/jats:title>\n                    <jats:p>Recognizing this pathway opens conceptual space for a new therapeutic toolkit\u00a0\u2013\u00a0one aimed at mitochondrial stabilization, inflammasome modulation, and restoring trophoblast resilience.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0706","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T15:51:57Z","timestamp":1779983517000},"page":"1213-1228","source":"Crossref","is-referenced-by-count":1,"title":["Inflammasome biology in preeclampsia: from Bnip3-mitophagy to Nlrp1-driven placental injury\u00a0\u2013\u00a0a systematic review and translational roadmap"],"prefix":"10.1515","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-3909","authenticated-orcid":false,"given":"Muhammad Adrianes","family":"Bachnas","sequence":"first","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Sebelas Maret University, Dr. Moewardi Hospital , Solo , Surakarta , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9062-8501","authenticated-orcid":false,"given":"Wiku","family":"Andonotopo","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Women\u2019s Health Center, Department of Obstetrics and Gynecology , Eka Hospital Serpong , Tangerang , Banten , Indonesia"},{"name":"Faculty of Medicine , Maranatha Christian University , Bandung , West Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wisnu","family":"Prabowo","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Sebelas Maret University, Dr. Moewardi Hospital , Solo , Surakarta , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Edwin","family":"Yuliantara","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Sebelas Maret University, Dr. Moewardi Hospital , Solo , Surakarta , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mochammad Besari","family":"Adi Pramono","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Dewantiningrum","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efendi","family":"Lukas","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine , Hasanuddin University of Makassar , Makassar , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Nyoman","family":"Hariyasa Sanjaya","sequence":"additional","affiliation":[{"name":"Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine , Udayana University, Prof. dr. 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I.G.N.G Ngoerah General Hospital , Bali , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanisyah Erza","family":"Gumilar","sequence":"additional","affiliation":[{"name":"Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine , Airlangga University, Dr. Soetomo Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernawati","family":"Darmawan","sequence":"additional","affiliation":[{"name":"Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine , Airlangga University, Dr. Soetomo Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ilham","family":"Aldika Akbar","sequence":"additional","affiliation":[{"name":"Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine , Airlangga University, Dr. Soetomo Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dovy","family":"Djanas","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine , Andalas University, M. Djamil General Hospital , Padang , West Sumatera , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudy","family":"Aldiansyah","sequence":"additional","affiliation":[{"name":"Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine , Sumatera Utara University, H. 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