{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:14:58Z","timestamp":1783440898379,"version":"3.54.6"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"6","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2025-0710_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Previable Preterm Premature Rupture of Membranes (PPPROM), defined as rupture of membrane (ROM) before fetal viability. Currently, it is recommended to counsel the family regarding expectant management (EM) vs. termination of pregnancy (TOP) given the increased maternal morbidity associated with EM. Additionally, there is limited knowledge of outcomes following ROM\u00a0\u226420\u00a0weeks. Given Mississippi\u2019s high-risk obstetric population and all mothers undergoing EM, we aimed to evaluate outcomes following PPPROM at our center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0710_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-center retrospective cohort study conducted of patients with PPPROM [&lt;24w gestational age (GA)] from 1\/1\/2014-2\/28\/2025. Demographic data and primary outcome of composite maternal morbidities and neonatal survival without severe morbidity were reviewed and compared between early (\u226420\u00a0weeks) vs. late (&gt;20\u00a0weeks)\u00a0ROM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0710_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total of 99 mothers (40 early vs. 59 late ROM) were included. 38\u202f% had spontaneous abortion. Composite maternal morbidity was 34\u202f%, with no difference between the groups. Each year increase in maternal age and gravidarum increased maternal morbidity by 10\u202f% and 23\u202f% respectively. Among live births, survival to discharge was 66\u202f%, and survival without severe morbidity was 47.5\u202f%, with no difference between groups. Increase in GA [OR 1.355 (1.095\u20131.678)], birth weight [OR 1.046 (1.011\u20131.183)], and 1-min Apgar [OR 1.35 (1.105\u20131.650)] showed higher survival without morbidity. Survival without morbidity increased with increase in latency period, only for ROM at early\u00a0GA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2025-0710_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PPPROM carries a substantial risk of maternal morbidity, which increases with maternal age and gravida. Among live births, neonatal survival without severe morbidity remained unchanged based on timing of\u00a0ROM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2025-0710","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:19:10Z","timestamp":1779103150000},"page":"1036-1046","source":"Crossref","is-referenced-by-count":0,"title":["Maternal and neonatal outcomes following expectant management of previable preterm premature rupture of membranes: a retrospective cohort study"],"prefix":"10.1515","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5984-4505","authenticated-orcid":false,"given":"Dipen","family":"Vyas","sequence":"first","affiliation":[{"name":"Department of Pediatrics\/Neonatology , University of Mississippi Medical Center , Jackson , MS , USA"},{"name":"Division of Neonatal-Perinatal Medicine , Northwell Health , Cohen Children\u2019s Medical Center , Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell , 269-71 76th Street , New York City , NY 11041 , USA"},{"name":"School of Medicine, University of Mississippi Medical Center , Jackson , MS , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachlan","family":"Shiver","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Neonatology , University of Mississippi Medical Center , Jackson , MS , USA"},{"name":"Department of Medicine , University of Mississippi Medical Center , Jackson , MS , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Neonatology , University of Mississippi Medical Center , Jackson , MS , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Butler","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Mississippi Medical Center , Jackson , MS , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin","family":"Crawson","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Mississippi Medical Center , Jackson , MS , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maher","family":"Ajour","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Neonatology , University of Mississippi Medical Center , Jackson , MS , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"2026070714574629527_j_jpm-2025-0710_ref_001","doi-asserted-by":"crossref","unstructured":"Society for Maternal-Fetal M, Battarbee, AN, Osmundson, SS, McCarthy, AM, Louis, JM. pubs@smfm.org SPCEa. 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