{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:56:54Z","timestamp":1787320614444,"version":"build-2736575974"},"reference-count":65,"publisher":"Walter de Gruyter GmbH","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2026-0068_abs_001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fetal programming has traditionally been interpreted through metabolic and endocrine paradigms, while maternal psychological regulation remains underdeveloped as\u00a0a biological determinant of neurodevelopment. Emerging evidence from placental biology, epigenetics, and fetal neuroimaging suggests that maternal psychological states may act not\u00a0only as contextual exposures but also as dynamic physiological signals during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0068_abs_002\">\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>This article proposes an integrative perspective in\u00a0which maternal psychological homeostasis is conceptualized as a multidimensional regulatory state encompassing endocrine, immune, autonomic, and circadian processes. We hypothesize that the placenta functions as an active signal-processing interface, translating maternal physiological signals into developmental cues. Potential mechanisms include glucocorticoid signaling, inflammatory pathways, and epigenetic regulation, which may influence fetal neural connectivity, stress-response systems, and early neurobehavioral organization. Although converging findings support biological plausibility, the evidence remains heterogeneous, with uncertainties regarding causality and timing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0068_abs_003\">\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Within this framework, fetal mental programming may arise, in part, from maternal psychological regulation as it is integrated within placental biology, involving interacting and temporally sensitive regulatory layers rather than a single pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0068_abs_004\">\n                    <jats:title>Outlook<\/jats:title>\n                    <jats:p>Future research should prioritize longitudinal human studies, validation of placental biomarkers, and identification of sensitive developmental windows. Improved understanding may support integration of mental health into perinatal care and inform early preventive strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2026-0068","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:59:11Z","timestamp":1787317151000},"source":"Crossref","is-referenced-by-count":0,"title":["Fetal mental programming: maternal psychological homeostasis as a placenta-mediated determinant of cognitive and emotional development\u00a0\u2013\u00a0an integrative perspective"],"prefix":"10.1515","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9062-8501","authenticated-orcid":false,"given":"Wiku","family":"Andonotopo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fetomaternal Division , Women Health Center, Ekahospital BSD City , Tangerang , Banten , Indonesia"},{"name":"Department of Medicine, Faculty of Medicine , Maranatha Christian University , Bandung , West Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-3909","authenticated-orcid":false,"given":"Muhammad Adrianes","family":"Bachnas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fetomaternal Division , Medical Faculty of Sebelas Maret University, Sebelas Maret University Hospital , Solo, Surakarta , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mochammad Besari","family":"Adi Pramono","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fetomaternal Division , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Dewantiningrum","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fetomaternal Division , Medical Faculty of Diponegoro University, Dr. Kariadi Hospital , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efendi","family":"Lukas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fetomaternal Division, Faculty of Medicine , Hasanuddin University of Makassar , Makassar , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Nyoman","family":"Hariyasa Sanjaya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Udayana University, Prof. Dr. I.G.N.G Ngoerah General Hospital , Denpasar , Bali , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anak Agung","family":"Gede Putra Wiradnyana","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Udayana University, Prof. Dr. I.G.N.G Ngoerah General Hospital , Denpasar , Bali , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anak Agung","family":"Ngurah Jaya Kusuma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Udayana University, Prof. Dr. I.G.N.G Ngoerah General Hospital , Denpasar , Bali , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanisyah Erza","family":"Gumilar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Airlangga University, Dr. Soetomo Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernawati","family":"Darmawan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Airlangga University, Dr. Soetomo Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ilham","family":"Aldika Akbar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Airlangga University, Dr. Soetomo Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dovy","family":"Djanas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fetomaternal Division, Faculty of Medicine , Andalas University, M. Djamil General Hospital , Padang , West Sumatera , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudy","family":"Aldiansyah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fetomaternal Division, Faculty of Medicine , Sumatera Utara University, H. 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Medicine, Faculty of Medicine , Maranatha Christian University , Bandung , West Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Frederik","family":"Lengkey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine , Maranatha Christian University , Bandung , West Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Windi","family":"Gunadi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine , Maranatha Christian University , Bandung , West Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita Deborah","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Padjajaran University, Hasan Sadikin General Hospital , Bandung , West Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cut Meurah","family":"Yeni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Syiah Kuala University, Dr. Zainoel Abidin General Hospital , Banda Aceh , Aceh , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryani","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Sriwijaya University, Dr. Mohammad Hoesin General Hospital , Palembang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuswil","family":"Bernolian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine , Sriwijaya University, Dr. Mohammad Hoesin General Hospital , Palembang , 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