{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:29:44Z","timestamp":1789046984445,"version":"build-2803163510"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"7","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2026-0086_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Prolonged neonatal hypoglycemia eventually resolving spontaneously is linked to perinatal stress, whereas persistent congenital hyperinsulinism is caused by genetic alterations leading to dysregulated insulin secretion. We investigated whether birth weight percentiles differ between both disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0086_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of birth weight percentiles in infants treated for prolonged neonatal hypoglycemia (n=9) or persistent neonatal hyperinsulinism (n=78) in two referral centers (2001\u20132023).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0086_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Infants with prolonged neonatal hypoglycemia had\u00a0significantly lower birth weight percentiles than those with persistent congenital hyperinsulinism (median 16 [interquartile range 4\u201372] vs. 89 [50\u201398]; p=0.003). The area under the receiver operator characteristics curve describing the power to discriminate between infants with prolonged neonatal hypoglycemia and persistent congenital hyperinsulinism was 0.801 (95\u202f% confidence interval 0.660\u20130.941), p&lt;0.001. Among infants with prolonged neonatal hypoglycemia, 4\/9 were small for gestational age (birth weight &lt;10th percentile), while 36\/78 infants with persistent congenital hyperinsulinism were large for gestational age (&gt;90th percentile). However, close to half of infants in each group had normal birth weights for gestational\u00a0age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0086_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While birth weight percentiles reflect differing fetal growth patterns in these conditions, they are insufficient as standalone diagnostic criteria. Additional algorithms are needed for accurate early identification and discrimination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2026-0086","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:46:55Z","timestamp":1781340415000},"page":"1190-1194","source":"Crossref","is-referenced-by-count":0,"title":["Birth weight percentiles in infants with neonatal-onset prolonged neonatal hypoglycemia and persistent congenital hyperinsulinism"],"prefix":"10.1515","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9588-0144","authenticated-orcid":false,"given":"Nino","family":"Zurebiani","sequence":"first","affiliation":[{"name":"Department of Neonatology , Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Berlin , Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ), Partner Site Berlin, Berlin , Germany"},{"name":"Institute of Medical Informatics, Charit\u00e9\u00a0\u2013\u00a0Universit\u00e4tsmedizin Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-414X","authenticated-orcid":false,"given":"Christoph","family":"B\u00fchrer","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Berlin , Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ), Partner Site Berlin, Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-5589","authenticated-orcid":false,"given":"Oliver","family":"Blankenstein","sequence":"additional","affiliation":[{"name":"German Center for Child and Adolescent Health (DZKJ), Partner Site Berlin, Berlin , Germany"},{"name":"Department of Pediatric Endocrinology and Diabetes , Charit\u00e9\u00a0\u2013\u00a0Universit\u00e4tsmedizin Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4336-8325","authenticated-orcid":false,"given":"Maximilian","family":"Groffmann","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care , University Medicine Greifswald , Greifswald , Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ), Partner Site Greifswald\/Rostock, Greifswald , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-264X","authenticated-orcid":false,"given":"Matthias","family":"Heckmann","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care , University Medicine Greifswald , Greifswald , Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ), Partner Site Greifswald\/Rostock, Greifswald , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-245X","authenticated-orcid":false,"given":"Katarina","family":"Braune","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Charit\u00e9\u00a0\u2013\u00a0Universit\u00e4tsmedizin Berlin , Berlin , Germany"},{"name":"Hasso Plattner Institute for Digital Engineering , University of Potsdam , Potsdam , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"2026091012590218796_j_jpm-2026-0086_ref_001","doi-asserted-by":"crossref","unstructured":"Sigal, WM, Alzahrani, O, Guadalupe, GM, Guzman, H, Radcliffe, J, Thomas, NH, et al.. 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