{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:30:05Z","timestamp":1789047005573,"version":"build-2803163510"},"reference-count":96,"publisher":"Walter de Gruyter GmbH","issue":"7","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2026-0266_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Prokineticin 1 (PROK1), known as endocrine gland-derived endothelial growth factor (EG-VEGF), is a key regulator of pregnancy, playing various roles from implantation to birth. We have shown that maternal serum concentrations of PROK1 are highest during the first trimester and are elevated in pregnancy complications such as spontaneous preterm birth (sPTB). Additionally, PROK1 is described as being largely expressed by the chorion in fetal membranes, suggesting its presence in amniotic fluid. Despite these findings, no information is available about PROK1 concentrations in the amniotic fluid, nor concerning its evolution in the context of spontaneous preterm labor with or without infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0266_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PROK1 concentrations were measured in amniotic fluid from patients with spontaneous preterm labor (n=45) and from women at term without sPTB (n=30).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0266_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings revealed that PROK1 concentrations were, i) significantly elevated in preterm labor patients compared to term laboring controls; ii) higher in spontaneous preterm labor patients with intra-amniotic infection compared to those without infection, and iii) not affected by the process of labor at\u00a0term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0266_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides the first comprehensive characterization of PROK1 concentrations in amniotic fluid, highlighting its potential involvement in spontaneous preterm labor, with or without infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2026-0266","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:00:56Z","timestamp":1782115256000},"page":"1116-1126","source":"Crossref","is-referenced-by-count":0,"title":["The cytokine prokineticin-1 in preterm labor with and without intra-amniotic inflammation"],"prefix":"10.1515","volume":"54","author":[{"given":"Morgane","family":"Desseux","sequence":"first","affiliation":[{"name":"Interdisciplinary Research Institute of Grenoble, IRIG-Biosant\u00e9, Biosciences and Biotechnology Institute of Grenoble, University Grenoble Alpes, INSERM, CEA, UMR 1292, France Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA) , Grenoble , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiphaine","family":"Raia-Barjat","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Institute of Grenoble, IRIG-Biosant\u00e9, Biosciences and Biotechnology Institute of Grenoble, University Grenoble Alpes, INSERM, CEA, UMR 1292, France Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA) , Grenoble , France"},{"name":"Department of Gynecology and Obstetrics , Centre Hospitalier Universitaire de Saint-\u00c9tienne , Saint-\u00c9tienne , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[{"name":"US Department of Health and Human Services , Pregnancy Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health , Bethesda , MD , USA"},{"name":"Department of Epidemiology and Biostatistics , Michigan State University , East Lansing , MI , USA"},{"name":"Department of Obstetrics and Gynecology , University of Michigan , Ann Arbor , MI , USA"},{"name":"George Washington University, School of Medicine and Health Sciences , Washington , DC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Institute of Grenoble, IRIG-Biosant\u00e9, Biosciences and Biotechnology Institute of Grenoble, University Grenoble Alpes, INSERM, CEA, UMR 1292, France Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA) , Grenoble , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Meyyazhagan","sequence":"additional","affiliation":[{"name":"US Department of Health and Human Services , Pregnancy Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health , Bethesda , MD , USA"},{"name":"Department of Obstetrics and Gynecology , Wayne State University School of Medicine , Detroit , MI , USA"},{"name":"Department of Life Sciences , Christ University , Bengaluru , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awoniyi O.","family":"Awonuga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Wayne State University School of Medicine , Detroit , MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinnakorn","family":"Chaiworapongsa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Wayne State University School of Medicine , Detroit , MI , 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