{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:30:03Z","timestamp":1789047003181,"version":"build-2803163510"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2026-0270_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Early assessment of hypoxic\u2013ischemic encephalopathy (HIE) severity is crucial, as therapeutic hypothermia should be initiated within the first 6\u202fh of life. This study aimed to evaluate early postnatal lactate, albumin, and lactate dehydrogenase (LDH) levels, together with derived lactate\/albumin (L\/A) and LDH\/albumin (LDH\/A) ratios, and to assess their discriminative performance in neonates with moderate-to-severe HIE treated with therapeutic hypothermia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0270_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case\u2013control study was conducted in a tertiary\u2013quaternary neonatal intensive care unit between January 2022 and December 2024. Term neonates (\u226536\u00a0weeks\u2019 gestation) diagnosed with moderate-to-severe HIE (stage II\u2013III) according to Thompson scoring and treated with therapeutic hypothermia were included. Healthy term neonates without perinatal asphyxia served as the control group. Early postnatal serum lactate, albumin, and LDH levels obtained within the first 6\u202fh of life were recorded, and L\/A and LDH\/A ratios were calculated. Group comparisons were performed, and the discriminative performance of the biomarkers was evaluated using receiver operating characteristic (ROC) curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0270_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 53 neonates with HIE and 84 healthy term controls were analyzed. Serum lactate and LDH levels, as well as L\/A and LDH\/A ratios, were significantly higher in the HIE group compared with controls (p&lt;0.001). ROC analysis demonstrated high discriminative performance for lactate (AUC: 0.987) and LDH\/A ratio (AUC: 0.973), while the L\/A ratio showed moderate discriminative ability (AUC: 0.793). Albumin alone did not demonstrate significant discriminative\u00a0value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0270_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early postnatal lactate- and LDH-based composite ratios, particularly the LDH\/A ratio, may serve as useful supportive biomarkers for the early identification of moderate-to-severe HIE. These readily available indices could assist clinical decision-making when advanced neurodiagnostic evaluations are delayed. Further prospective and multicenter studies are warranted to validate their diagnostic utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2026-0270","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:55:52Z","timestamp":1783349752000},"page":"1182-1189","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic value of lactate\/albumin and lactate dehydrogenase\/albumin ratios in newborns with hypoxic-ischemic encephalopathy"],"prefix":"10.1515","volume":"54","author":[{"given":"Seyma","family":"Butun Turk","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Division of Neonatology, Health Sciences University, Ankara Bilkent City Hospital , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Senol","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Neonatology, Health Sciences University, Ankara Bilkent City Hospital , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seray","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Neonatology, Health Sciences University, Ankara Bilkent City Hospital , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Ceran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Neonatology, Health Sciences University, Ankara Bilkent City Hospital , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuneyt","family":"Tayman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Neonatology, Health Sciences University, Ankara Bilkent City Hospital , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Cakir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Division of Neonatology, Health Sciences University, Ankara Bilkent City Hospital , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"2026091012590222342_j_jpm-2026-0270_ref_001","doi-asserted-by":"crossref","unstructured":"Douglas-Escobar, M, Weiss, MD. Hypoxic-ischemic encephalopathy: a review for the clinician. JAMA Pediatr 2015;169:397\u2013403. https:\/\/doi.org\/10.1001\/jamapediatrics.2014.3269.","DOI":"10.1001\/jamapediatrics.2014.3269"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_002","doi-asserted-by":"crossref","unstructured":"Hagberg, H, Mallard, C, Ferriero, DM, Vannucci, SJ, Levison, SW, Vexler, ZS, et al.. The role of inflammation in perinatal brain injury. Nat Rev Neurol 2015;11:192\u2013208. https:\/\/doi.org\/10.1038\/nrneurol.2015.13.","DOI":"10.1038\/nrneurol.2015.13"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_003","doi-asserted-by":"crossref","unstructured":"Shankaran, S, Laptook, AR, Ehrenkranz, RA, Tyson, JE, McDonald, SA, Donovan, EF, et al.. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N\u00a0Engl J Med 2005;353:1574\u201384. https:\/\/doi.org\/10.1056\/nejmcps050929.","DOI":"10.1056\/NEJMcps050929"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_004","doi-asserted-by":"crossref","unstructured":"Muniraman, H, Gardner, D, Skinner, J, Paweletz, A, Vayalakkad, A, Chee, YH, et al.. Biomarkers of hepatic injury and function in neonatal hypoxic ischemic encephalopathy and with therapeutic hypothermia. Eur J Pediatr 2017;176:1295\u2013303. https:\/\/doi.org\/10.1007\/s00431-017-2956-2.","DOI":"10.1007\/s00431-017-2956-2"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_005","doi-asserted-by":"crossref","unstructured":"Caramelo, I, Coelho, M, Rosado, M, Cardoso, CMP, Dinis, A, Duarte, CB, et al.. Biomarkers of hypoxic-ischemic encephalopathy: a systematic review. 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Intensive Care Med 1980;7:19\u201322. https:\/\/doi.org\/10.1007\/bf01692917.","DOI":"10.1007\/BF01692917"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_008","doi-asserted-by":"crossref","unstructured":"Jeon, SY, Ryu, S, Oh, SK, Park, JS, You, YH, Jeong, WJ, et al.. Lactate dehydrogenase to albumin ratio as a prognostic factor for patients with severe infection requiring intensive care. Medicine (Baltim) 2021;100:e27538. https:\/\/doi.org\/10.1097\/md.0000000000027538.","DOI":"10.1097\/MD.0000000000027538"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_009","doi-asserted-by":"crossref","unstructured":"Kim, S, Lee, S, Ahn, S, Park, J, Moon, S, Cho, H, et al.. The prognostic utility of lactate\/albumin*age score in septic patient with normal lactate level. Heliyon 2024;10:e37056. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e37056.","DOI":"10.1016\/j.heliyon.2024.e37056"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_010","doi-asserted-by":"crossref","unstructured":"Alkholy, UM, Abdalmonem, N, Zaki, A, Ali, YF, Mohamed, SA, Abdelsalam, NI, et al.. Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy. Neuropsychiatr Dis Treat 2017;13:2133\u20139. https:\/\/doi.org\/10.2147\/ndt.s144225.","DOI":"10.2147\/NDT.S144225"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_011","doi-asserted-by":"crossref","unstructured":"Akisu, M, Kumral, A, Canpolat, FE. Turkish neonatal society guideline on neonatal encephalopathy. Turk Pediatri Ars 2018;53:S32\u201344. https:\/\/doi.org\/10.5152\/turkpediatriars.2018.01805.","DOI":"10.5152\/TurkPediatriArs.2018.01805"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_012","doi-asserted-by":"crossref","unstructured":"Aggarwal, R, Ranganathan, P. 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T\u00fcrkiye \u00c7ocuk Hast Derg 2020;14:493\u20139. https:\/\/doi.org\/10.12956\/tchd.591883.","DOI":"10.12956\/tchd.591883"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_017","doi-asserted-by":"crossref","unstructured":"Ceran, B, Alyama\u00e7 Dizdar, E, Be\u015fer, E, Kara\u00e7a\u011flar, NB, Sar\u0131, FN. Diagnostic role of systemic inflammatory indices in infants with moderate-to-severe hypoxic ischemic encephalopathy. Am J Perinatol 2024;41:248\u201354. https:\/\/doi.org\/10.1055\/a-1673-1616.","DOI":"10.1055\/a-1673-1616"},{"key":"2026091012590222342_j_jpm-2026-0270_ref_018","doi-asserted-by":"crossref","unstructured":"Yang, M, Wang, K, Liu, B, Shen, Y. Hypoxic-ischemic encephalopathy: pathogenesis and promising therapies. 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