{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:06:22Z","timestamp":1789571182413,"version":"build-2803163510"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2026-0450_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the association between parental ethnicity and respiratory outcomes in infants born before 34\u00a0weeks of gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0450_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective matched case-comparison study of inborn infants admitted to two London tertiary neonatal units between September 2022 and September 2025. Infants were included if both parents self-identified as Black (African or Caribbean) or White (British, Irish or Other) ethnicity. Clinical data were collected from electronic records. The primary outcome was the rate of bronchopulmonary dysplasia (BPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0450_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>394 infants (197 Black, 197 White) were matched by gestational age (GA). The Black cohort had higher rates of gestational diabetes (GDM) (20.5 vs. 7.6\u202f%, p&lt;0.001) and of being small for gestational age (SGA) (32.0 vs. 19.3\u202f%, p=0.004). After adjustment for GA, GDM and SGA, infants of Black ethnicity had significantly lower odds of requiring mechanical ventilation (p=0.029) and of the composite outcome of BPD or death (p=0.04). When the Black cohort was divided into African (n=157) and Caribbean (n=40) infants, African ethnicity was associated with lower rates of BPD (p=0.011) and of BPD or death (p=0.014) compared with White ethnicity. Caribbean infants had the highest rates of mechanical ventilation (p=0.017) and use of inhaled nitric oxide (p=0.039), and longer durations of mechanical ventilation (p=0.003) and admission (p=0.047), but had similar odds of BPD or of BPD\/death to White infants (p=0.98 and p=0.73, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2026-0450_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this UK cohort of preterm infants, respiratory outcomes differed by ethnicity. Further work is needed to identify the genetic, environmental and structural drivers of these difference so that interventions can be appropriately targeted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2026-0450","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:56:21Z","timestamp":1789570581000},"source":"Crossref","is-referenced-by-count":0,"title":["Respiratory morbidity and mortality in Black and White preterm infants"],"prefix":"10.1515","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4857-0990","authenticated-orcid":false,"given":"Eleanor","family":"Jeffreys","sequence":"first","affiliation":[{"name":"Department of Women and Children\u2019s Health , School of Life Course Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London , London , UK"},{"name":"Neonatal Intensive Care Centre, King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1461-5527","authenticated-orcid":false,"given":"Serena","family":"Gandino","sequence":"additional","affiliation":[{"name":"Evelina Neonatal Intensive Care Unit , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0642-1637","authenticated-orcid":false,"given":"Charlie","family":"Gill","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Centre, King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-5301","authenticated-orcid":false,"given":"Theodore","family":"Dassios","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health , School of Life Course Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London , London , UK"},{"name":"Neonatal Intensive Care Centre, King\u2019s College Hospital NHS Foundation Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-7626","authenticated-orcid":false,"given":"Suresh","family":"Victor","sequence":"additional","affiliation":[{"name":"Evelina Neonatal Intensive Care Unit , London , UK"},{"name":"Institute of Pharmaceutical Sciences , King\u2019s College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-5349","authenticated-orcid":false,"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health , School of Life Course Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"2026091614561895824_j_jpm-2026-0450_ref_001","doi-asserted-by":"crossref","unstructured":"Bradley, E, Blencowe, H, Moller, AB, Okwaraji, YB, Sadler, F, Gruending, A, et al.. Born too soon: global epidemiology of preterm birth and drivers for change. Reprod Health 2025;22:105. https:\/\/doi.org\/10.1186\/s12978-025-02033-x.","DOI":"10.1186\/s12978-025-02033-x"},{"key":"2026091614561895824_j_jpm-2026-0450_ref_002","unstructured":"Office for National Statistics. Birth characteristics in England and Wales: 2022 [Internet]; 2024. Available from: https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/livebirths\/bulletins\/birthcharacteristicsinenglandandwales\/2022."},{"key":"2026091614561895824_j_jpm-2026-0450_ref_003","doi-asserted-by":"crossref","unstructured":"Anadkat, JS, Kuzniewicz, MW, Chaudhari, BP, Cole, FS, Hamvas, A. Increased risk for respiratory distress among white, male, late preterm and term infants. 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