{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:02:48Z","timestamp":1778641368338,"version":"3.51.4"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Brain-derived neurotrophic factor (BDNF) is highly expressed in the developing brain. It has anti-apoptotic abilities, and protects the neonatal brain. In experimental settings in adult animals, pre-treatment with nicotine has shown increased BDNF levels, indicating a possible contribution to nicotine's anti-apoptotic effect. Apoptosis contributes to the development of brain damage in perinatal asphyxia. We examined the effects of nicotine on apoptosis-inducing factor (AIF), caspase-3 and BDNF in the hippocampus of a neonatal piglet model of global hypoxia. Forty-one anesthetized newborn piglets were randomized to one of four groups receiving different infusions after hypoxia (1) nicotine 130\u00a0\u03bcg\/kg\/h, 2) 260 \u03bcg\/kg\/h, 3) adrenaline, and 4) saline, all 2.6\u00a0mL\/kg\/h. Four hours after hypoxia they were euthanized. The left hemisphere\/hippocampus was examined by histopathology and immunohistochemistry; the right hippocampus was analyzed using real time PCR. There was a significantly higher expression of BDNF mRNA and protein in the animals treated with nicotine 130\u00a0\u03bcg\/kg\/h vs. the saline treated group (mRNA P=0.038; protein P=0.009). There were no differences regarding AIF or caspase-3. We conclude that nicotine (130\u00a0\u03bcg\/kg\/h), infused over 1 h after global hypoxia in neonatal piglets, increases levels of both BDNF mRNA and protein in the hippocampus. This might imply neuroprotective effects of nicotine in asphyxiated neonates.<\/jats:p>","DOI":"10.1515\/jpm.2009.081","type":"journal-article","created":{"date-parts":[[2009,6,3]],"date-time":"2009-06-03T12:12:47Z","timestamp":1244031167000},"page":"553-560","source":"Crossref","is-referenced-by-count":25,"title":["Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets"],"prefix":"10.1515","volume":"37","author":[{"given":"Jannicke Hanne","family":"Andresen","sequence":"first","affiliation":[{"name":"Department of Pediatric Research, Institute of Surgical Research, Medical Faculty, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Else Marit","family":"L\u00f8berg","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ullev\u00e5l University Hospital, Oslo, 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