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If a seroconversion is documented or a fetal infection is suspected by ultrasound markers, an amniocentesis should be performed to confirm a vertical transmission. In the absence of a confirmed fetal infection with fetal structural anomalies, a pregnancy termination should be discouraged. Fetal prognosis is mainly correlated to the presence of brain damage. Despite promising results with the use of antiviral drugs and CMV hyperimmune globulin (HIG), results have to be interpreted with caution. Pregnant women should not be systematically tested for CMV during pregnancy. Managing CMV screening should be restricted to pregnancies where a primary infection is suspected or among women at high risk. The magnitude of congenital CMV disease and the value of interventions to prevent its transmission or to decrease the sequelae need to be established before implementing public health interventions. In this paper, aspects of CMV infection in the pregnant woman and her infant are reviewed.<\/jats:p>","DOI":"10.1515\/jpm.2009.127","type":"journal-article","created":{"date-parts":[[2009,8,13]],"date-time":"2009-08-13T11:49:16Z","timestamp":1250164156000},"page":"433-445","source":"Crossref","is-referenced-by-count":84,"title":["Guidelines on CMV congenital infection"],"prefix":"10.1515","volume":"37","author":[{"given":"Oriol","family":"Coll","sequence":"first","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Benoist","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, Hospital Necker-Enfants-Malades, Universit\u00e9 Paris Descartes, 149 rue de S\u00e8vres, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Ville","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, Hospital Necker-Enfants-Malades, Universit\u00e9 Paris Descartes, 149 rue de S\u00e8vres, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard E.","family":"Weisman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics at Baylor College of Medicine, and Perinatal Center at Texas Children's Hospital, 6621 Fannin Street Suite FC830.19, Houston, TX 77030-2303, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Botet","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia, Hospital Clinic, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"the WAPM Perinatal Infections Working Group:","family":"Maurizio M. 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