{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T20:07:22Z","timestamp":1760472442460},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Objective: To evaluate the clinical presentation, possible etiological factors, management and\noutcome of patients in our hospital with extrahepatic portal vein obstruction (EHPVO). Materials\nand Methods: This study included patients with EHPVO followed up in our department during\nlast 10 years. Patients of cirrhosis with EHPVO were excluded. Patients\u2019 clinical presentation,\netiology of EHPVO, management and outcome results were analyzed. Results: Of 30 patients,\n19 (67.9%) were males. Median age was 12 years. Of 14 patients who underwent liver biopsy\n9 had histological activity index stage of 1\/6. History of omphalitis and pulmonary tuberculosis\nwas present in one case each. Of 22 patients with the available thrombophilia profile, nine\npatients had a deficiency of protein C, five patients had a deficiency of protein S, one each\nhad reduced level S of anti-thrombin III and factor V mutation. The predominant presenting\nsymptom was hematemesis (15 patients, 53.6%). Seven patients (25%) had splenomegaly.\nThree patients (10.7%) had no esophageal varices on endoscopy. Three patients underwent\nsplenectomy due to severe pancytopenia. Endoscopic retrograde cholangipancreatography\nwas performed in four patients (14.3%) due to portal biliopathy. Common bile duct stenting was\nperformed in all four patients. Of them, one patient underwent splenorenal shunt operation for\nindication of hemobilia. One patient died at the age of 40 years, due to cholangitis and sepsis.\nConclusions: Results from this study show that the anticoagulant deficiency is a common\ncause of EHPVO in our setup. Hematemesis is a common presenting symptom. Some of these\npatients have symptomatic portal biliopathy.<\/jats:p>","DOI":"10.1515\/jtim-2015-0007","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T10:22:28Z","timestamp":1480933348000},"page":"74-78","source":"Crossref","is-referenced-by-count":7,"title":["Clinical presentation of\nextrahepatic portal vein obstruction:\n10-year experience at a tertiary care\nhospital in Pakistan"],"prefix":"10.1515","volume":"3","author":[{"given":"Farina M.","family":"Hanif","sequence":"first","affiliation":[{"name":"Departments of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghous Bux","family":"Soomro","sequence":"additional","affiliation":[{"name":"Departments of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Nazir","family":"Akhund","sequence":"additional","affiliation":[{"name":"Departments of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasir Hassan","family":"Luck","sequence":"additional","affiliation":[{"name":"Departments of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Mudassir","family":"Laeeq","sequence":"additional","affiliation":[{"name":"Departments of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaigham","family":"Abbas","sequence":"additional","affiliation":[{"name":"Departments of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Mujahid","family":"Hassan","sequence":"additional","affiliation":[{"name":"Departments of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed","family":"Mubarak","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,6,30]]},"container-title":["Journal of Translational Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/jtim\/3\/2\/article-p74.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jtim-2015-0007\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jtim-2015-0007\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T08:22:28Z","timestamp":1682410948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jtim-2015-0007\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,6,30]]}},"alternative-id":["10.1515\/jtim-2015-0007"],"URL":"https:\/\/doi.org\/10.1515\/jtim-2015-0007","relation":{},"ISSN":["2224-4018"],"issn-type":[{"value":"2224-4018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,30]]}}}